1.
Rheumatology (Oxford)
; 63(9): e261-e263, 2024 Sep 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38335932
2.
Indian J Pediatr
; 2023 Dec 12.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38085415
RESUMEN
Besides genetic susceptibility, infections due to viruses, bacteria and protozoa have been implicated in the development of autoimmune diseases (AD). AD can be triggered in a genetically susceptible individual by infections that disrupt immunological tolerance towards self-antigens. Pathogens can initiate autoimmunity by way of molecular mimicry, bystander activation, epitope spreading or persistent infection with polyclonal activation. This review covers two main topics: (i) the mechanisms by which an infectious agent can trigger or worsen autoimmunity; and (ii) the correlation between specific infectious agents and AD in humans with special emphasis on multisystem inflammatory syndrome in children (MIS-C).