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1.
BMC Pediatr ; 19(1): 386, 2019 10 27.
Artículo en Inglés | MEDLINE | ID: mdl-31656181

RESUMEN

BACKGROUND: Diarrhea and acute respiratory infection (ARI) are major causes of child mortality. We aimed to identify risk factors associated with diarrhea and ARI among children under 2 years of age in rural northern Bangladesh. METHOD: We collected information on diarrhea and ARI in the previous 14 days and the previous 6 months at 6, 12, 18 and 24 months of age as part of a longitudinal, cluster randomized effectiveness trial, the Rang-Din Nutrition Study which enrolled 4011 pregnant women at ≤20 gestational weeks. Women and their children were followed up until 2 years postpartum. Information on household socioeconomic status, type of toilet, garbage disposal system, food insecurity, number of under-five children in the household, type of family, maternal characteristics and child characteristics was collected at baseline and/or at 6, 12, 18 and 24 months postpartum. Data on newborn health and feeding behaviors were collected within 72 h of delivery. Associations between potential risk factors and morbidity prevalence outcomes were assessed using logistic regression controlling for potential confounders. RESULTS: Out of 3664 live born children, we collected information from ~ 3350 children at 6, 12, 18 and 24 months of age. Diarrhea in the previous 14 days, and in the previous 6 months, was associated with maternal depression score and food insecurity; diarrhea in the previous 6 months was also associated with family type (nuclear vs. joint). ARI in the previous 14 days was associated with maternal depression score, type of toilet and garbage disposal, household food insecurity and sex. Cough or nasal discharge in the past 6 months was associated with maternal depression score, type of toilet and garbage disposal, household food insecurity, sex and perceived overall physical condition of the infant after birth. CONCLUSION: Maternal depression and food insecurity appear to be important risk factors for diarrhea and respiratory infection among children under 2 years of age in this setting. These findings suggest that policies and programs that include strategies to address maternal mental health and household food insecurity may contribute to improved child health. TRIAL REGISTRATION: The trial was registered with the US National Institutes of Health at ClinicalTrials.gov, # NCT01715038 , with registration completed October 26, 2012.


Asunto(s)
Diarrea Infantil/epidemiología , Infecciones del Sistema Respiratorio/epidemiología , Enfermedad Aguda , Bangladesh/epidemiología , Femenino , Humanos , Recién Nacido , Estudios Longitudinales , Masculino , Factores de Riesgo , Salud Rural
2.
Matern Child Nutr ; 15(4): e12844, 2019 10.
Artículo en Inglés | MEDLINE | ID: mdl-31106491

RESUMEN

Prenatal nutritional supplements may improve birth outcomes. This study aims to examine the effect of prenatal lipid-based nutrient supplements (LNS), compared with iron and folic acid (IFA), on general newborn physical condition and feeding behaviours. We conducted a cluster-randomized effectiveness trial that enrolled 4,011 pregnant women at ≤20 gestational weeks. LNS and IFA were provided to women in 48 and 16 clusters, respectively, for daily consumption until delivery. We collected data on household socio-economic, food insecurity, and maternal characteristics during early pregnancy and on newborn condition and feeding within 72 hr of delivery. We analysed intervention effects on these secondary outcomes using mixed models with analysis of covariance for continuous outcomes and logistic regression for dichotomous outcomes. Among 3,664 live births, intervention groups did not differ in newborn response, mother's rating of the general condition of her newborn, early initiation of breastfeeding (EIBF), suckling ability, or frequency and exclusivity of breastfeeding in the first 24 hr. If the mother perceived her infant to be healthy, EIBF was more likely (OR [95% CI]: 2.08 [1.46, 2.97]) and frequency of breastfeeding in the first 24 hr was greater (mean difference [95% CI]: 3.0 [1.91, 4.01]), but there was no difference in exclusive breastfeeding in the first 24 hr. Newborn condition and early breastfeeding practices were not affected by giving mothers prenatal LNS versus IFA. However, early breastfeeding practices were related to maternal perception of her newborn's condition. Thus, interventions to improve breastfeeding practices for newborns with poorer perceived health status may be useful.


Asunto(s)
Lactancia Materna/estadística & datos numéricos , Fenómenos Fisiologicos Nutricionales Maternos/fisiología , Resultado del Embarazo/epidemiología , Atención Prenatal , Adolescente , Adulto , Suplementos Dietéticos , Femenino , Ácido Fólico/administración & dosificación , Ácido Fólico/uso terapéutico , Humanos , Lactante , Salud del Lactante , Recién Nacido , Hierro/administración & dosificación , Hierro/uso terapéutico , Lípidos/administración & dosificación , Lípidos/uso terapéutico , Masculino , Embarazo , Adulto Joven
3.
J Nutr ; 147(9): 1776-1784, 2017 09.
Artículo en Inglés | MEDLINE | ID: mdl-28724657

RESUMEN

Background: Pregnancy and childbirth complications and cesarean delivery are common in Bangladesh.Objective: We evaluated the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on pregnancy and childbirth complications and cesarean delivery.Methods: We conducted the Rang-Din Nutrition Study, a cluster-randomized controlled effectiveness trial within a community health program in rural Bangladesh. We enrolled 4011 pregnant women in early pregnancy. Women in 48 clusters received iron and folic acid (IFA; 60 mg Fe + 400 µg folic acid/d) and women in 16 clusters received LNS-PL (20 g/d, 118 kcal) containing essential fatty acids and 22 vitamins and minerals. Pregnancy and childbirth complications and the cesarean delivery rate were secondary outcomes of the study.Results: Women in the LNS-PL group did not differ significantly from the IFA group with respect to mean systolic blood pressure at 36 wk gestation (113 and 112 mm Hg; P = 0.17), diastolic blood pressure at 36 wk gestation (68.9 and 68.7 mmHg; P = 0.88), or mean total number of pregnancy and childbirth complications (0.32 and 0.31; P = 0.86). They also did not differ significantly with respect to the prevalence of high blood pressure at 36 wk (1.74% and 2.03%; P = 0.62), antepartum hemorrhage (0.83% and 1.39%; P = 0.21), prolonged labor (8.34% and 8.79%; P = 0.68), early rupture of membranes (9.30% and 8.45%; P = 0.43), convulsions (1.57% and 1.08%; P = 0.24), high blood pressure in labor (1.54% and 1.19%; P = 0.46), obstructed labor (2.83% and 2.91%; P = 0.90), any complications during pregnancy or childbirth (35.9% and 37.1%; P = 0.64), episiotomy (6.31% and 6.44%; P = 0.90), or cesarean delivery (15.6% and 14.2%; P = 0.48).Conclusion: Compared with IFA, antenatal LNS-PL did not increase or decrease pregnancy and childbirth complications or cesarean delivery among women in rural Bangladesh. This trial was registered at clinicaltrials.gov as NCT01715038.


Asunto(s)
Cesárea , Suplementos Dietéticos , Ácidos Grasos Esenciales/farmacología , Micronutrientes/farmacología , Complicaciones del Embarazo , Adolescente , Adulto , Bangladesh , Presión Sanguínea , Episiotomía , Femenino , Hemorragia , Humanos , Hipertensión Inducida en el Embarazo , Lípidos/farmacología , Fenómenos Fisiologicos Nutricionales Maternos , Complicaciones del Trabajo de Parto , Embarazo , Rotura , Convulsiones , Adulto Joven
4.
J Nutr ; 147(8): 1586-1592, 2017 08.
Artículo en Inglés | MEDLINE | ID: mdl-28615379

RESUMEN

Background: Maternal iodine deficiency during pregnancy and lactation is common in Bangladesh.Objective: We evaluated the effect of lipid-based nutrient supplements for pregnant and lactating women (LNS-PL) on urinary iodine concentration (UIC).Methods: We conducted a cluster-randomized controlled effectiveness trial in which we enrolled 4011 pregnant women at ≤20 gestational weeks. Women in 48 clusters received iron and folic acid (IFA; 60 mg Fe/d + 400 µg folic acid/d) and women in 16 clusters received LNS-PL (20 g/d, 118 kcal) containing 22 vitamins and minerals (including 250 µg I). We randomly selected a subsample of 1159 women for repeated urine sample collection, i.e., at enrollment, at 36 wk of gestation, and at 6 mo postpartum, for UIC analysis, a secondary outcome of the trial.Results: The geometric mean UIC at 36 wk of gestation and at 6 mo postpartum did not differ significantly between the IFA and LNS-PL groups. The median (quartile 1, quartile 3) UIC at 36 wk was 27.4 µg/L (16.9, 52.7 µg/L) in the IFA group and 30.2 µg/L (17.7, 56.6 µg/L) in the LNS-PL group; at 6 mo, these were 23.0 µg/L (10.0, 45.9 µg/L) in the IFA group and 22.2 µg/L (9.1, 50.4 µg/L) in the LNS-PL group.Conclusion: Daily consumption of LNS-PL containing 250 µg I did not increase the UICs of pregnant and lactating women in Bangladesh. Iodine from lipid-based nutrient supplements may have been stored in the thyroid gland or secreted in breast milk instead of being excreted in urine. Additional research that uses other biomarkers of iodine status is needed to determine how to meet the iodine requirements of pregnant and lactating women in Bangladesh and similar settings. This trial was registered at clinicaltrials.gov as NCT01715038.


Asunto(s)
Enfermedades Carenciales/dietoterapia , Suplementos Dietéticos , Yodo , Lactancia , Fenómenos Fisiologicos Nutricionales Maternos , Estado Nutricional , Complicaciones del Embarazo , Adolescente , Adulto , Bangladesh , Biomarcadores/orina , Enfermedades Carenciales/metabolismo , Femenino , Humanos , Yodo/deficiencia , Yodo/farmacocinética , Yodo/uso terapéutico , Yodo/orina , Lactancia/metabolismo , Lípidos , Micronutrientes/uso terapéutico , Necesidades Nutricionales , Periodo Posparto , Embarazo , Complicaciones del Embarazo/dietoterapia , Complicaciones del Embarazo/metabolismo , Oligoelementos/deficiencia , Oligoelementos/farmacocinética , Oligoelementos/uso terapéutico , Oligoelementos/orina , Resultado del Tratamiento , Adulto Joven
5.
J Clin Periodontol ; 43(11): 909-917, 2016 11.
Artículo en Inglés | MEDLINE | ID: mdl-27394059

RESUMEN

AIM: To evaluate the relationship between periodontal diseases and subclinical atherosclerosis in a younger and lean South Asian population. METHODS: We conducted a cross-sectional study in 917 subjects (mean age 46 years and mean body mass index 21.1 kg/m2 ) from the Health Effects of Arsenic Longitudinal Study in Bangladesh. Multivariate linear regression models were used to assess the associations between multiple clinical measures of periodontal diseases and carotid intima-media thickness (IMT). RESULTS: Mean attachment loss (AL) and percentage of sites with AL ≥ 4 mm (% AL ≥ 4) were associated with increased IMT. The IMT was 20.0-µm (95% CI: 2.2, 37.8) and 26.5-µm (95% CI: 8.9, 44.1) higher in subjects in the top quartile of mean AL (>3.72 mm) and % AL ≥ 4 (>58.4%), respectively, compared to those in the bottom quartile. In a subset of 366 subjects, mean AL was positively associated with plasma levels of matrix metalloproteinase-9 (p < 0.05) and soluble intercellular adhesion molecule-1 (p < 0.01). CONCLUSIONS: Attachment loss was associated with subclinical atherosclerosis in this young and lean Bangladeshi population. Future prospective studies are needed to confirm this association.


Asunto(s)
Grosor Intima-Media Carotídeo , Enfermedades Periodontales , Aterosclerosis , Bangladesh , Enfermedades de las Arterias Carótidas , Estudios Transversales , Humanos , Estudios Longitudinales , Persona de Mediana Edad , Estudios Prospectivos , Factores de Riesgo
6.
Toxicol Appl Pharmacol ; 276(3): 195-203, 2014 May 01.
Artículo en Inglés | MEDLINE | ID: mdl-24593923

RESUMEN

Epidemiologic studies that evaluated genetic susceptibility for the effects of arsenic exposure from drinking water on subclinical atherosclerosis are limited. We conducted a cross-sectional study of 1078 participants randomly selected from the Health Effects of Arsenic Longitudinal Study in Bangladesh to evaluate whether the association between arsenic exposure and carotid artery intima-media thickness (cIMT) differs by 207 single-nucleotide polymorphisms (SNPs) in 18 genes related to arsenic metabolism, oxidative stress, inflammation, and endothelial dysfunction. Although not statistically significant after correcting for multiple testing, nine SNPs in APOE, AS3MT, PNP, and TNF genes had a nominally statistically significant interaction with well-water arsenic in cIMT. For instance, the joint presence of a higher level of well-water arsenic (≥ 40.4 µg/L) and the GG genotype of AS3MT rs3740392 was associated with a difference of 40.9 µm (95% CI = 14.4, 67.5) in cIMT, much greater than the difference of cIMT associated with the genotype alone (ß = -5.1 µm, 95% CI = -31.6, 21.3) or arsenic exposure alone (ß = 7.2 µm, 95% CI = -3.1, 17.5). The pattern and magnitude of the interactions were similar when urinary arsenic was used as the exposure variable. Additionally, the at-risk genotypes of the AS3MT SNPs were positively related to the proportion of monomethylarsonic acid (MMA) in urine, which is indicative of arsenic methylation capacity. The findings provide novel evidence that genetic variants related to arsenic metabolism may play an important role in arsenic-induced subclinical atherosclerosis. Future replication studies in diverse populations are needed to confirm the findings.


Asunto(s)
Arsénico/efectos adversos , Enfermedades Cardiovasculares/genética , Grosor Intima-Media Carotídeo , Predisposición Genética a la Enfermedad , Polimorfismo de Nucleótido Simple , Contaminantes Químicos del Agua/efectos adversos , Abastecimiento de Agua , Adulto , Bangladesh , Estudios Transversales , Femenino , Genotipo , Humanos , Masculino , Metiltransferasas/genética , Persona de Mediana Edad , Abastecimiento de Agua/análisis
7.
Am J Epidemiol ; 178(3): 372-81, 2013 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-23788675

RESUMEN

We conducted a cross-sectional study to evaluate the interrelationships between past arsenic exposure, biomarkers specific for susceptibility to arsenic exposure, and carotid intima-media thickness (cIMT) in 959 subjects from the Health Effects of Arsenic Longitudinal Study in Bangladesh. We measured cIMT levels on average 7.2 years after baseline during 2010-2011. Arsenic exposure was measured in well water at baseline and in urine samples collected at baseline and during follow-up. Every 1-standard-deviation increase in urinary arsenic (357.9 µg/g creatinine) and well-water arsenic (102.0 µg/L) concentration was related to a 11.7-µm (95% confidence interval (CI): 1.8, 21.6) and 5.1-µm (95% CI: -0.2, 10.3) increase in cIMT, respectively. For every 10% increase in monomethylarsonic acid (MMA) percentage, there was an increase of 12.1 µm (95% CI: 0.4, 23.8) in cIMT. Among participants with a higher urinary MMA percentage, a higher ratio of urinary MMA to inorganic arsenic, and a lower ratio of dimethylarsinic acid to MMA, the association between well-water arsenic and cIMT was stronger. The findings indicate an effect of past long-term arsenic exposure on cIMT, which may be potentiated by suboptimal or incomplete arsenic methylation capacity. Future prospective studies are needed to confirm the association between arsenic methylation capacity and atherosclerosis-related outcomes.


Asunto(s)
Arsénico/análisis , Enfermedades Cardiovasculares/epidemiología , Grosor Intima-Media Carotídeo , Agua Potable/análisis , Exposición a Riesgos Ambientales/análisis , Monitoreo del Ambiente/métodos , Contaminantes Químicos del Agua/análisis , Adulto , Antropometría , Arsénico/metabolismo , Arsenicales/orina , Bangladesh/epidemiología , Biomarcadores/orina , Ácido Cacodílico/orina , Enfermedades Cardiovasculares/diagnóstico por imagen , Arterias Carótidas/diagnóstico por imagen , Causalidad , Estudios de Cohortes , Comorbilidad , Estudios Transversales , Monitoreo del Ambiente/estadística & datos numéricos , Femenino , Humanos , Estudios Longitudinales , Masculino , Metilación , Estudios Prospectivos , Factores de Riesgo , Distribución por Sexo , Factores Sexuales , Fumar/epidemiología , Abastecimiento de Agua/análisis , Pozos de Agua/análisis
8.
BMJ Open ; 13(11): e073743, 2023 11 19.
Artículo en Inglés | MEDLINE | ID: mdl-37984955

RESUMEN

OBJECTIVE: The critical shortage of healthcare workers, particularly in rural areas, is a major barrier to quality care for non-communicable diseases (NCD) in low-income and middle-income countries. In this proof-of-concept study, we aimed to test a decentralised model for integrated diabetes and hypertension management in rural Bangladesh to improve accessibility and quality of care. DESIGN AND SETTING: The study is a single-cohort proof-of-concept study. The key interventions comprised shifting screening, routine monitoring and dispensing of medication refills from a doctor-managed subdistrict NCD clinic to non-physician health worker-managed village-level community clinics; a digital care coordination platform was developed for electronic health records, point-of-care support, referral and routine patient follow-up. The study was conducted in the Parbatipur subdistrict, Rangpur Division, Bangladesh. PARTICIPANTS: A total of 624 participants were enrolled in the study (mean (SD) age, 59.5 (12.0); 65.1% female). OUTCOMES: Changes in blood pressure and blood glucose control, patient retention and patient-visit volume at the NCD clinic and community clinics. RESULTS: The proportion of patients with uncontrolled blood pressure reduced from 60% at baseline to 26% at the third month of follow-up, a 56% (incidence rate ratio 0.44; 95% CI 0.33 to 0.57) reduction after adjustment for covariates. The proportion of patients with uncontrolled blood glucose decreased from 74% to 43% at the third month of follow-up. Attrition rates immediately after baseline and during the entire study period were 29.1% and 36.2%, respectively. CONCLUSION: The proof-of-concept study highlights the potential for involving lower-level primary care facilities and non-physician health workers to rapidly expand much-needed services to patients with hypertension and diabetes in Bangladesh and in similar global settings. Further investigations are needed to evaluate the effectiveness of decentralised hypertension and diabetes care.


Asunto(s)
Diabetes Mellitus , Hipertensión , Enfermedades no Transmisibles , Humanos , Femenino , Persona de Mediana Edad , Masculino , Bangladesh , Enfermedades no Transmisibles/terapia , Tecnología Digital , Hipertensión/tratamiento farmacológico , Hipertensión/diagnóstico , Diabetes Mellitus/terapia , Calidad de la Atención de Salud , Política
9.
J Nutr ; 142(11): 2010-6, 2012 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-22990469

RESUMEN

Placental growth is a strong predictor of fetal growth, but little is known about maternal predictors of placental growth in malnourished populations. Our objective was to investigate in a prospective study the associations of maternal weight and body composition [total body water (TBW) estimated by bioelectrical impedance and fat and fat-free mass derived from upper arm fat and muscle areas (UAFA, UAMA)] and changes in these with placental and birth weights. Within a cluster-randomized trial of maternal micronutrient supplementation, a subsample of 350 women was measured 3 times across gestation. Longitudinal analysis was used to examine independent associations of ∼10-wk measurements and ∼10-20 wk and ∼20-32 wk changes with birth outcomes. Weight, TBW, and UAMA, but not UAFA, at ∼10 wk were each positively and independently associated with placental weight and birth weight (P < 0.05). Of the maternal ∼10-20 wk changes in measurements, only TBW change and placental weight, and maternal weight and birth weight were positively associated (P < 0.05). Gains in weight, TBW, and UAMA from 20 to 32 wk were positively and UAFA gain was negatively associated with placental weight (P ≤ 0.01). Gains in weight and UAMA from 20 to 32 wk were positively associated with birth weight (P ≤ 0.01). Overall, higher maternal weight and measures of fat-free mass at ∼10 wk gestation and gains from 20 to 32 wk are independently associated with higher placental and birth weight.


Asunto(s)
Peso al Nacer , Peso Corporal , Placenta/anatomía & histología , Adulto , Bangladesh , Análisis por Conglomerados , Femenino , Humanos , Recién Nacido , Micronutrientes/administración & dosificación , Micronutrientes/farmacología , Tamaño de los Órganos , Embarazo , Adulto Joven
10.
PLoS One ; 15(1): e0226923, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-31951620

RESUMEN

BACKGROUND: In Sunamganj there are fewer than four skilled providers per 10,000 population and just 27% of births are assisted by a skilled attendant. We evaluate a private community skilled birth attendant (P-CSBA) model, developed through the GSK-CARE Frontline Health Worker Programme, designed to address this gap and report on changes in service utilization and health outcomes from baseline to three years post-baseline. METHODS: This analysis presents the results of a pre-post cross sectional design. A baseline survey (n = 1800) was conducted using a multistage cluster sampling approach. Three years post-baseline a second cross-sectional survey (n = 1755) was conducted across the same project area. To describe demographic characteristics of the study participants descriptive statistical techniques were used as appropriate. Logistic and multiple logistic regression, controlling for a comprehensive set of covariates, were used to assess odds ratios for key maternal health behaviors and outcomes. RESULTS: Birth planning and the use of key maternal health services improved from baseline to follow-up. There was a dramatic increase in the proportion of respondents reporting skilled attendance at birth (aOR: 2.18, p = .001). Women also reported significantly fewer complications during the prenatal (aOR: .30, p<.001), labor and delivery (aOR: 0.41, p<.0001) and postnatal periods (aOR: 0.32, p<.0001). CONCLUSION: Private-sector approaches, when coupled with robust efforts to strengthen and collaborate with the public sector, can work successfully to deliver services in underserved communities. The success of this model lends credence to the growing appreciation that reaching our development targets will require governments to work in partnership with private sector actors and highlights the potential of private-public partnerships as we drive towards universal health coverage.


Asunto(s)
Parto Obstétrico/estadística & datos numéricos , Asociación entre el Sector Público-Privado , Adulto , Bangladesh , Estudios Transversales , Femenino , Humanos , Modelos Logísticos , Servicios de Salud Materna , Embarazo , Atención Prenatal , Servicios de Salud Rural , Adulto Joven
11.
J Health Popul Nutr ; 35(1): 34, 2016 10 21.
Artículo en Inglés | MEDLINE | ID: mdl-27769295

RESUMEN

BACKGROUND: The best method of gestational age assessment is by ultrasound in the first trimester; however, this method is impractical in large field trials in rural areas. Our objective was to assess the validity of gestational age estimated from prospectively collected date of last menstrual period (LMP) using crown-rump length (CRL) measured in early pregnancy by ultrasound. METHODS: As part of a large, cluster-randomized, controlled trial in rural Bangladesh, we collected dates of LMP by recall and as marked on a calendar every 5 weeks in women likely to become pregnant. Among those with a urine-test confirmed pregnancy, a subset with gestational age of <15 weeks (n = 353) were enrolled for ultrasound follow-up to measure CRL. We compared interview-assessed LMP with CRL gestational age estimates and classification of preterm, term, and post-term births. RESULTS: LMP-based gestational age was higher than CRL by a mean (SD) of 2.8 (10.7) days; differences varied by maternal education and preterm birth (P < 0.05). Lin's concordance correlation coefficient was good at ultrasound [0.63 (95 % CI 0.56, 0.69)] and at birth [0.77 (95 % CI 0.73, 0.81)]. Validity of classifying preterm birth was high but post-term was lower, with specificity of 96 and 89 % and sensitivity of 86 and 67 %, respectively. Results were similar by parity. CONCLUSIONS: Prospectively collected LMP provided a valid estimate of gestational age and preterm birth in a rural, low-income setting and may be a suitable alternative to ultrasound in programmatic settings and large field trials. TRIAL REGISTRATION: ClinicalTrials.gov NCT00860470.


Asunto(s)
Edad Gestacional , Recien Nacido Prematuro , Menstruación , Recuerdo Mental , Población Rural , Adolescente , Adulto , Bangladesh , Femenino , Humanos , Recién Nacido , Pobreza , Embarazo , Pruebas de Embarazo , Atención Prenatal , Tiempo , Ultrasonografía Prenatal , Adulto Joven
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