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Design and synthesis of amidino-tyrosine derivatives as non-peptide fibrinogen receptor antagonists.
Bioorg Med Chem Lett
; 9(14): 1933-6, 1999 Jul 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-10450956
RESUMEN
The design, synthesis and antiaggregation activity of amidino-tyrosine derivatives based on Arg-Gly-Asp (RGD) tripeptide sequence as non-peptide fibrinogen receptor antagonists is described. Optimization of the spacer and the substituent at the C-terminal is reported.