RESUMEN
The analgesic efficacy of 100 and 200 mg isoxepac was compared with that of 50 mg indomethacin in a double-blind, single-dose, between-patient (parallel) study with placebo control. Oral doses were administered to 120 patients whose postoperative plan justified administration of analgesics on the morning of the day following knee surgery for meniscectomy. No appreciable differences emerged between 100 mg isoxepac and placebo, though 50 mg indomethacin and 200 mg isoxepac gave better analgesia than either 100 mg isoxepac or placebo. Peak and duration of pain relief was of the same order with 50 mg indomethacin, and 200 mg isoxepac would appear to be the minimal effective dose in the clinical setting of postoperative pain following knee meniscectomy. The incidence of side effects on all three active treatments was remarkedly low.
Asunto(s)
Acetatos/uso terapéutico , Antiinflamatorios no Esteroideos , Dolor Postoperatorio/tratamiento farmacológico , Acetatos/efectos adversos , Adolescente , Adulto , Antiinflamatorios no Esteroideos/efectos adversos , Ensayos Clínicos como Asunto , Método Doble Ciego , Humanos , Indometacina/uso terapéutico , Articulación de la Rodilla/cirugía , Persona de Mediana Edad , Factores de TiempoRESUMEN
To assess the risk of Strongyloides stercoralis transmission from two patients with disseminated strongyloidiasis to medical staff who had been in close contact with the patients, blood and stool specimens were obtained from medical staff two to three months after close contact with the patients. Antibodies to S. stercoralis were determined in blood. Stool specimens were tested for parasites with three different procedures.Forty-one medical staff were included. Culture and stool examination were negative in all subjects. Serology was negative in all subjects but one who had a borderline titer without signs or symptoms of strongyloidiasis. No evidence of transmission of S. stercoralis from patients with disseminated strongyloidiasis to medical staff was found.
Asunto(s)
Transmisión de Enfermedad Infecciosa de Paciente a Profesional/prevención & control , Cuerpo Médico de Hospitales , Personal de Enfermería en Hospital , Strongyloides stercoralis , Estrongiloidiasis/transmisión , Anciano , Animales , Humanos , Transmisión de Enfermedad Infecciosa de Paciente a Profesional/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Países Bajos/epidemiología , Estrongiloidiasis/epidemiología , Estrongiloidiasis/prevención & controlRESUMEN
The administration of alfentanil by continuous infusion as supplementation to nitrous oxide for shortlasting anesthesias has been studied in 51 patients. Anesthesia was induced with thiopental 4 to 5 mg/kg-1. Analgesia was performed by a continuous infusion of alfentanil (0.1 mg.ml-1 in glucose 5%) preceded by a bolus injection of 0.5 mg alfentanil i.v. Supplementations of 0.25 mg alfentanil i.v. were given if indicated. The patients were divided into 4 groups, according to the rate of infusion (group I: 4 mg.hr-1; group II: 5 mg.hr-1) and to the addition of either droperidol (group III) or domperidone (group IV). Anesthesia was satisfactory in all cases. Alfentanil given by continuous infusion (4 mg/hr-1) preceded by a bolus injection (0.5 mg) provided a good basic analgesia. With this method of administration the awakening time was shorter and less analgesic was needed than after incremental dosages of alfentanil. Droperidol, almost abolished nausea and vomiting postoperatively. It, however, clearly potentiated the effect of alfentanil. Domperidone given instead of droperidol had no or little effect on postoperative nausea and vomiting.