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1.

c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis.

Leslie, Jack; Hunter, Jill E; Collins, Amy; Rushton, Amelia; Russell, Lauren G; Ramon-Gil, Erik; Laszczewska, Maja; McCain, Misti; Zaki, Marco Y W; Knox, Amber; Seow, Yixin; Sabater, Laura; Geh, Daniel; Perkins, Neil D; Reeves, Helen L; Tiniakos, Dina; Mann, Derek A; Oakley, Fiona.

Hepatology; 78(4): 1050-1063, 2023 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-36089330

2.

Alphabetti kinase Spaghetti: the complex roles of IKKα and ß in the canonical NF-κB pathway.

Perkins, Neil D.

Biochem J; 479(11): 1121-1126, 2022 06 17.

Artículo en Inglés | MEDLINE | ID: mdl-35647902

3.

Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential.

Madgwick, Suzanne; Luli, Saimir; Sellier, Helene; Butterworth, Jacqueline A; Leslie, Jack; Moore, Adam J; Corbin, Emma K; Yemm, Adrian I; Chiremba, Robson T; Tiniakos, Dina; Oakley, Fiona; Perkins, Neil D; Hunter, Jill E.

Biochem J; 479(19): 2115-2130, 2022 10 14.

Artículo en Inglés | MEDLINE | ID: mdl-36240068

4.

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.

Hunter, Jill E; Campbell, Amy E; Hannaway, Nicola L; Kerridge, Scott; Luli, Saimir; Butterworth, Jacqueline A; Sellier, Helene; Mukherjee, Reshmi; Dhillon, Nikita; Sudhindar, Praveen D; Shukla, Ruchi; Brownridge, Philip J; Bell, Hayden L; Coxhead, Jonathan; Taylor, Leigh; Leary, Peter; Hasoon, Megan S R; Collins, Ian; Garrett, Michelle D; Eyers, Claire E; Perkins, Neil D.

Biochem J; 479(19): 2063-2086, 2022 10 14.

Artículo en Inglés | MEDLINE | ID: mdl-36240066

5.

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells.

Hunter, Jill E; Campbell, Amy E; Kerridge, Scott; Fraser, Callum; Hannaway, Nicola L; Luli, Saimir; Ivanova, Iglika; Brownridge, Philip J; Coxhead, Jonathan; Taylor, Leigh; Leary, Peter; Hasoon, Megan S R; Eyers, Claire E; Perkins, Neil D.

Biochem J; 479(19): 2131-2151, 2022 10 14.

Artículo en Inglés | MEDLINE | ID: mdl-36240067

6.

A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells.

Cuevas-Ocaña, Sara; Yang, Jin Ye; Aushev, Magomet; Schlossmacher, George; Bear, Christine E; Hannan, Nicholas R F; Perkins, Neil D; Rossant, Janet; Wong, Amy P; Gray, Michael A.

Int J Mol Sci; 24(12)2023 Jun 17.

Artículo en Inglés | MEDLINE | ID: mdl-37373413

7.

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage.

Campbell, Amy E; Ferraz Franco, Catarina; Su, Ling-I; Corbin, Emma K; Perkins, Simon; Kalyuzhnyy, Anton; Jones, Andrew R; Brownridge, Philip J; Perkins, Neil D; Eyers, Claire E.

Biochem J; 478(3): 533-551, 2021 02 12.

Artículo en Inglés | MEDLINE | ID: mdl-33438746

8.

Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21.

Yamada, Kayo; Ono, Motoharu; Perkins, Neil D; Rocha, Sonia; Lamond, Angus I.

Mol Cell; 49(5): 922-33, 2013 Mar 07.

Artículo en Inglés | MEDLINE | ID: mdl-23375502

9.

Cysteine 38 holds the key to NF-κB activation.

Perkins, Neil D.

Mol Cell; 45(1): 1-3, 2012 Jan 13.

Artículo en Inglés | MEDLINE | ID: mdl-22244324

10.

Induction of the immunoprotective coat of Yersinia pestis at body temperature is mediated by the Caf1R transcription factor.

Al-Jawdah, Abdulmajeed D; Ivanova, Iglika G; Waller, Helen; Perkins, Neil D; Lakey, Jeremy H; Peters, Daniel T.

BMC Microbiol; 19(1): 68, 2019 03 29.

Artículo en Inglés | MEDLINE | ID: mdl-30922226

11.

RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation.

Szoltysek, Katarzyna; Janus, Patryk; Zajac, Gracjana; Stokowy, Tomasz; Walaszczyk, Anna; Widlak, Wieslawa; Wojtas, Bartosz; Gielniewski, Bartlomiej; Cockell, Simon; Perkins, Neil D; Kimmel, Marek; Widlak, Piotr.

BMC Genomics; 19(1): 813, 2018 Nov 12.

Artículo en Inglés | MEDLINE | ID: mdl-30419821

12.

The Skp2 promoter integrates signaling through the NF-kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis.

Barré, Benjamin; Perkins, Neil D.

Mol Cell; 38(4): 524-38, 2010 May 28.

Artículo en Inglés | MEDLINE | ID: mdl-20513428

13.

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance.

Hunter, Jill E; Campbell, Amy E; Butterworth, Jacqueline A; Sellier, Helene; Hannaway, Nicola L; Luli, Saimir; Floudas, Achilleas; Kenneth, Niall S; Moore, Adam J; Brownridge, Philip J; Thomas, Huw D; Coxhead, Jonathan; Taylor, Leigh; Leary, Peter; Hasoon, Megan S R; Knight, Andrew M; Garrett, Michelle D; Collins, Ian; Eyers, Claire E; Perkins, Neil D.

Biochem J; 479(19): 2087-2113, 2022 10 14.

Artículo en Inglés | MEDLINE | ID: mdl-36240065

14.

More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription.

Perkins, Neil D.

EMBO J; 37(24)2018 12 14.

Artículo en Inglés | MEDLINE | ID: mdl-30509970

15.

Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.

Iannetti, Alessio; Ledoux, Adeline C; Tudhope, Susan J; Sellier, Hélène; Zhao, Bo; Mowla, Sophia; Moore, Adam; Hummerich, Holger; Gewurz, Benjamin E; Cockell, Simon J; Jat, Parmjit S; Willmore, Elaine; Perkins, Neil D.

PLoS Genet; 10(9): e1004642, 2014 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-25255445

16.

Nuclear factor-κB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect.

Johnson, Renée F; Perkins, Neil D.

Trends Biochem Sci; 37(8): 317-24, 2012 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-22626470

17.

c-Rel and its many roles in cancer: an old story with new twists.

Hunter, Jill E; Leslie, Jack; Perkins, Neil D.

Br J Cancer; 114(1): 1-6, 2016 Jan 12.

Artículo en Inglés | MEDLINE | ID: mdl-26757421

18.

Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins.

Bonacci, Thomas; Audebert, Stéphane; Camoin, Luc; Baudelet, Emilie; Bidaut, Ghislain; Garcia, Maxime; Witzel, Ini-Isabée; Perkins, Neil D; Borg, Jean-Paul; Iovanna, Juan-Lucio; Soubeyran, Philippe.

J Proteome Res; 13(5): 2478-94, 2014 May 02.

Artículo en Inglés | MEDLINE | ID: mdl-24654937

19.

NF-κB and the cell cycle.

Ledoux, Adeline C; Perkins, Neil D.

Biochem Soc Trans; 42(1): 76-81, 2014 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-24450631

20.

Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response.

Moles, Anna; Sanchez, Ana M; Banks, Paul S; Murphy, Lindsay B; Luli, Saimir; Borthwick, Lee; Fisher, Andrew; O'Reilly, Steven; van Laar, Jacob M; White, Steven A; Perkins, Neil D; Burt, Alastair D; Mann, Derek A; Oakley, Fiona.

Hepatology; 57(2): 817-28, 2013 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-22996371

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c-Rel-dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis.

Alphabetti kinase Spaghetti: the complex roles of IKKα and ß in the canonical NF-κB pathway.

Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential.

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.

Up-regulation of the PI3K/AKT and RHO/RAC/PAK signalling pathways in CHK1 inhibitor resistant Eµ-Myc lymphoma cells.

A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells.

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage.

Identification and functional characterization of FMN2, a regulator of the cyclin-dependent kinase inhibitor p21.

Cysteine 38 holds the key to NF-κB activation.

Induction of the immunoprotective coat of Yersinia pestis at body temperature is mediated by the Caf1R transcription factor.

RRAD, IL4I1, CDKN1A, and SERPINE1 genes are potentially co-regulated by NF-κB and p53 transcription factors in cells exposed to high doses of ionizing radiation.

The Skp2 promoter integrates signaling through the NF-kappaB, p53, and Akt/GSK3beta pathways to regulate autophagy and apoptosis.

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance.

More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription.

Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence.

Nuclear factor-κB, p53, and mitochondria: regulation of cellular metabolism and the Warburg effect.

c-Rel and its many roles in cancer: an old story with new twists.

Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins.

NF-κB and the cell cycle.

Inhibition of RelA-Ser536 phosphorylation by a competing peptide reduces mouse liver fibrosis without blocking the innate immune response.