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1.
Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD.
Neurobiol Dis;
179: 106050, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36809847
2.
Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core.
Bioorg Med Chem;
52: 116528, 2021 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34839158
3.
Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and other tauopathies.
Eur J Nucl Med Mol Imaging;
46(10): 2178-2189, 2019 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-31264169
4.
Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of ß-amyloid-42 aggregation for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett;
27(6): 1405-1411, 2017 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28216401
5.
Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of ß-amyloid-42 aggregation.
Bioorg Med Chem Lett;
26(14): 3330-3335, 2016 07 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27256911
6.
Human genome-guided identification of memory-modulating drugs.
Proc Natl Acad Sci U S A;
110(46): E4369-74, 2013 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-24145423
7.
TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice.
Blood;
121(1): 85-94, 2013 Jan 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-23144170
8.
An effector-reduced anti-ß-amyloid (Aß) antibody with unique aß binding properties promotes neuroprotection and glial engulfment of Aß.
J Neurosci;
32(28): 9677-89, 2012 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-22787053
9.
Discovery and structure activity relationship of small molecule inhibitors of toxic ß-amyloid-42 fibril formation.
J Biol Chem;
287(41): 34786-800, 2012 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-22891248
10.
Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework.
MAbs;
15(1): 2232087, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37408314
11.
Modeling Alzheimer's disease related phenotypes in the Ts65Dn mouse: impact of age on Aß, Tau, pTau, NfL, and behavior.
Front Neurosci;
17: 1202208, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37449271
12.
Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF.
Brain Commun;
5(6): fcad306, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-38025276
13.
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.
Nat Commun;
14(1): 6750, 2023 10 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-37891183
14.
Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species.
J Biol Chem;
286(10): 8585-8596, 2011 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-21156804
15.
Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.
J Biol Chem;
286(16): 13966-76, 2011 Apr 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-21343310
16.
Beneficial Effect of ACI-24 Vaccination on Aß Plaque Pathology and Microglial Phenotypes in an Amyloidosis Mouse Model.
Cells;
12(1)2022 12 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36611872
17.
Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial.
JAMA Neurol;
79(6): 565-574, 2022 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35532913
18.
PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.
J Med Chem;
64(17): 12808-12830, 2021 09 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34455780
19.
Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.
Sci Transl Med;
13(593)2021 05 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33980574
20.
Quenched substrates for live-cell labeling of SNAP-tagged fusion proteins with improved fluorescent background.
Anal Chem;
82(19): 8186-93, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20815338