Detalles de la búsqueda
1.
A novel mouse model for N-terminal truncated Aß2-x generation through meprin ß overexpression in astrocytes.
Cell Mol Life Sci;
81(1): 139, 2024 Mar 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38480559
2.
Pathogenic Aß production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
J Biol Chem;
299(8): 104997, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37394008
3.
Antibody-mediated inhibition of tissue-type plasminogen activator binding to the low-density lipoprotein receptor-related protein 1 as a potential beneficial modulator for stroke therapy.
J Cell Biochem;
124(7): 1040-1049, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37288821
4.
PCSK9 acts as a key regulator of Aß clearance across the blood-brain barrier.
Cell Mol Life Sci;
79(4): 212, 2022 Mar 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-35344086
5.
Meprin ß knockout reduces brain Aß levels and rescues learning and memory impairments in the APP/lon mouse model for Alzheimer's disease.
Cell Mol Life Sci;
79(3): 168, 2022 Mar 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35235058
6.
The Blood-Brain Barrier in Alzheimer's Disease.
Handb Exp Pharmacol;
273: 247-266, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-33580390
7.
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Cell Mol Life Sci;
77(2): 331-350, 2020 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-31209506
8.
Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
Int J Mol Sci;
22(9)2021 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34066779
9.
Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures.
Glia;
68(12): 2517-2549, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32579270
10.
Tethering soluble meprin α in an enzyme complex to the cell surface affects IBD-associated genes.
FASEB J;
33(6): 7490-7504, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30916990
11.
The metalloprotease ADAMTS4 generates N-truncated Aß4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Acta Neuropathol;
137(2): 239-257, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30426203
12.
Regulatory effects of simvastatin and apoJ on APP processing and amyloid-ß clearance in blood-brain barrier endothelial cells.
Biochim Biophys Acta Mol Cell Biol Lipids;
1863(1): 40-60, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28941799
13.
Ectodomain shedding of CD99 within highly conserved regions is mediated by the metalloprotease meprin ß and promotes transendothelial cell migration.
FASEB J;
31(3): 1226-1237, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28003343
14.
The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM.
Brain Behav Immun;
73: 21-33, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30041013
15.
Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.
Bioorg Med Chem Lett;
28(8): 1417-1422, 2018 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29463448
16.
Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.
Biochemistry;
56(51): 6713-6725, 2017 12 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29185711
17.
Endothelial LRP1 - A Potential Target for the Treatment of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.
Pharm Res;
34(12): 2637-2651, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-28948494
18.
Low density lipoprotein receptor-related protein 1 mediated endocytosis of ß1-integrin influences cell adhesion and cell migration.
Exp Cell Res;
340(1): 102-15, 2016 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26610862
19.
Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation.
Glia;
64(8): 1363-80, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27258849
20.
Metalloprotease meprin ß is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding.
Biochem J;
470(1): 91-103, 2015 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26251449