Detalles de la búsqueda
1.
Identification and optimization of a novel series of selective PIP5K inhibitors.
Bioorg Med Chem;
54: 116557, 2022 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34922306
2.
Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.
Bioorg Med Chem Lett;
39: 127904, 2021 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33684441
3.
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
J Med Chem;
67(4): 3090-3111, 2024 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38306388
4.
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
Bioorg Med Chem Lett;
23(5): 1212-6, 2013 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23375793
5.
A concise total synthesis of deoxyschizandrin and exploration of its antiproliferative effects and those of structurally related derivatives.
Chemistry;
18(11): 3193-8, 2012 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22307955
6.
The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
Bioorg Med Chem Lett;
22(12): 3879-83, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22608965
7.
Sulfonyl-morpholino-pyrimidines: SAR and development of a novel class of selective mTOR kinase inhibitor.
Bioorg Med Chem Lett;
22(12): 4163-8, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22607682
8.
Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life.
Bioorg Med Chem Lett;
21(11): 3467-70, 2011 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21515051
9.
Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase.
J Med Chem;
64(23): 17146-17183, 2021 12 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34807608
10.
Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
J Med Chem;
64(20): 15189-15213, 2021 10 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-34647738
11.
Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically.
Mol Cancer Ther;
19(1): 13-25, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31534013
12.
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
J Med Chem;
63(24): 15564-15590, 2020 12 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-33306391
13.
Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR.
Bioorg Med Chem Lett;
19(20): 5898-901, 2009 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19733066
14.
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors.
ACS Med Chem Lett;
9(8): 809-814, 2018 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30128072
15.
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
J Med Chem;
61(9): 3823-3841, 2018 05 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29683659
16.
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.
Sci Adv;
4(6): eaat1719, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29938225
17.
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Mol Cancer Ther;
17(8): 1637-1647, 2018 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-29769307
18.
Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
J Med Chem;
59(13): 6281-92, 2016 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27259031
19.
Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.
Sci Signal;
9(445): ra91, 2016 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27625305
20.
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.
Medchemcomm;
7(8): 1580-1586, 2016 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27746890