Detalles de la búsqueda
1.
Discovery and structure-activity relationships (SAR) of a novel class of 2-substituted N-piperidinyl indole-based nociceptin opioid receptor ligands.
Bioorg Med Chem;
92: 117421, 2023 09 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37573822
2.
Differential In Vitro Pharmacological Profiles of Structurally Diverse Nociceptin Receptor Agonists in Activating G Protein and Beta-Arrestin Signaling at the Human Nociceptin Opioid Receptor.
Mol Pharmacol;
100(1): 7-18, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33958480
3.
A Novel and Selective Nociceptin Receptor (NOP) Agonist (1-(1-((cis)-4-isopropylcyclohexyl)piperidin-4-yl)-1H-indol-2-yl)methanol (AT-312) Decreases Acquisition of Ethanol-Induced Conditioned Place Preference in Mice.
Alcohol Clin Exp Res;
42(2): 461-471, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-29215139
4.
Structure-based virtual screening of the nociceptin receptor: hybrid docking and shape-based approaches for improved hit identification.
J Chem Inf Model;
54(10): 2732-43, 2014 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-25148595
5.
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.
Bioorg Med Chem;
22(8): 2508-16, 2014 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24657054
6.
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.
Bioorg Med Chem Lett;
23(11): 3308-13, 2013 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23623415
7.
Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics.
Sci Rep;
12(1): 7154, 2022 05 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35504962
8.
Differential effects of nociceptin/orphanin FQ (NOP) receptor agonists in acute versus chronic pain: studies with bifunctional NOP/µ receptor agonists in the sciatic nerve ligation chronic pain model in mice.
J Pharmacol Exp Ther;
339(2): 687-93, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21859931
9.
The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward.
J Pharmacol Exp Ther;
336(3): 952-61, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21177476
10.
Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models.
J Med Chem;
63(5): 2688-2704, 2020 03 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31951130
11.
Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/mu-opioid receptor agonists.
J Pharmacol Exp Ther;
331(3): 946-53, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19713488
12.
Comparison of the antinociceptive and antirewarding profiles of novel bifunctional nociceptin receptor/mu-opioid receptor ligands: implications for therapeutic applications.
J Pharmacol Exp Ther;
331(3): 954-64, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19773529
13.
Synthesis, Biological Evaluation, and SAR Studies of 14ß-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile.
Front Psychiatry;
9: 430, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30283364
14.
A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
Sci Transl Med;
10(456)2018 08 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-30158150
15.
Anti-Parkinsonian and anti-dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists.
Br J Pharmacol;
175(5): 782-796, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29232769
16.
Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodents.
Eur J Pharmacol;
560(1): 29-35, 2007 Mar 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-17303110
17.
Probing ligand recognition of the opioid pan antagonist AT-076 at nociceptin, kappa, mu, and delta opioid receptors through structure-activity relationships.
Sci Rep;
7(1): 13255, 2017 10 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29038479
18.
In Vitro and In Vivo Profile of PPL-101 and PPL-103: Mixed Opioid Partial Agonist Analgesics with Low Abuse Potential.
Front Psychiatry;
8: 52, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28446883
19.
In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations.
Eur J Pharmacol;
793: 1-13, 2016 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27780725
20.
Discovery of the first small-molecule opioid pan antagonist with nanomolar affinity at mu, delta, kappa, and nociceptin opioid receptors.
ACS Chem Neurosci;
6(4): 646-57, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25635572