1.
Chem Commun (Camb)
; 53(36): 4919-4921, 2017 May 02.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28401215
RESUMEN
RNA is essential to all life on Earth and is the leading candidate for the first biopolymer of life. Aminooxazolines have recently emerged as key prebiotic ribonucleotide precursors, and here we develop a novel strategy for aminooxazoline-5'-phosphate synthesis in water from prebiotic feedstocks. Oxidation of acrolein delivers glycidaldehyde (90%), which directs a regioselective phosphorylation in water and specifically affords 5'-phosphorylated nucleotide precursors in upto 36% yield. We also demonstrated a generational link between proteinogenic amino acids (Met, Glu, Gln) and nucleotide synthesis.
Asunto(s)
Evolución Química , Oxazoles/síntesis química , Fosforilación Oxidativa , Agua/química , Acroleína/química , Aldehídos/química , Compuestos Epoxi/química , Estructura Molecular , Origen de la Vida , Oxazoles/química , Oxidación-Reducción , Estereoisomerismo
2.
Matern Child Nurs J
; 7(2): 73-86, 1978.
Artículo
en Inglés
| MEDLINE
| ID: mdl-247126