[COMPARATIVE CHARACTERISTICS OF EPIDEMIC SEASONS OF INFLUENZA 2015-2016AND 2009 -2010].

AIM: Analyze epidemiologic and- clinical features of influenza epidemic seasons 2009 - 2010 and 2015 - 2016. Materials and methods Forms of federal state statistic observation No.4 , 2, 5, and 6; information from the official web-site of the Research Institute of Influenza of the Ministry of Health of Russian Federation; materials of various conferences and congresses on problems of influenza; information-analytical certificates of the Ministry of Health .of Russian Federation. RESULTS: Epidemic morbidity increases in the season 2009 - 2010. and 2015 - 2016 started at various time and had different duration. Children younger than 14 years of age predominated in the structure of patients in the 2009 - 2010 epidemic season, the main mass of patients were presented by individuals aged 45 - 59 years in the 2015 - 2016 season. The number of lethal outcomes with laboratory confirmed influenza diagnosis in 2009 - 2010 was 687-cases, and in 2015 - 2016 - 663 cases. Almost all the deceased from influenza were not vaccinated against this infection. Cardiovascular system diseases were noted in 484 individuals of the total number of deceased. Most of the deceased were late to seek medical aid. CONCLUSION: Influenza epidemic season 2015 - 2016 differs from 2009 - 2010 season by dynamics of morbidity development and a lower amount of severe forms of the disease and lethal outcomes. This may be-due to an increase of population immunity against pandemic strain A(H1N1)pdm09 via pro-epidemizing in the recent years as well as an increase of influenza vaccination coverage.

[Analysis of the short-term and long-term results in surgical treatment of the chronic cystic pancreatitis].

INTRODUCTION: In recent years, the practice of abdominal surgery marked increase in the number of patients with pancreatic cysts. Tactics of treatment of this disease is still disputable. MATERIAL AND METHODS: The article analyzes the treatment of 128 patients with formed pancreatic cysts. They were divided into three groups: 1) external drainage - 44 (34.4%); 2) internal drainage - 41 (32.0%); 3) resection surgery - 43 (33.6%). RESULTS: The duodenum resections were introduced for the treatment of the pancreatic head cysts - 21 (48.8%). Resection methods in the number of postoperative complications (23.3%) could be compared with the operations of the internal drainage of pancreatic cysts (19.5%), although the resection methods are technically more difficult and traumatic. 66 (51.6%) patients were observed in the long-term period. The number of postoperated disease recurrences was more in group 1 (28.6%). Quality of life indicators (SF-36) were higher in group 3. We marked the best results after resection operations. CONCLUSION: So this type of operation can be recommended for the treatment of patients with formed pancreatic cysts as the most radical method.

Biodegradable iron-silicon implants produced by additive manufacturing.

Due to many negative and undesirable side effects from the use of permanent implants, the development of temporary implants based on biocompatible and biodegradable materials is a promising area of modern medicine. In the presented study, we have investigated complex-shaped iron-silicon (Fe-Si) scaffolds that can be used as potential biodegradable framework structures for solid implants for bone grafting. Since iron and silicon are biocompatible materials, and their alloy should also have biocompatibility. It has been demonstrated that cells, mesenchymal stromal cells derived from the human umbilical cord (UC-MSC) and 3T3, were attached to, spread, and proliferated on the Fe-Si scaffolds' surface. Most of UC-MSC and 3T3 remained viable, only single dead cells were observed. According to the results of biological testing, the scaffolds have shown that deposition of calcium phosphate particles occurs on day one in the scaffold at the defect site that can be used as a primary marker of osteodifferentiation. These results demonstrate that the 3D-printed porous iron-silicon (Fe-Si) alloy scaffolds are promising structures for bone grafting and regeneration.