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1.
Alzheimer's disease-associated R47H TREM2 increases, but wild-type TREM2 decreases, microglial phagocytosis of synaptosomes and neuronal loss.
Glia;
71(4): 974-990, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36480007
2.
A calcium-sensitive antibody isolates soluble amyloid-ß aggregates and fibrils from Alzheimer's disease brain.
Brain;
145(7): 2528-2540, 2022 07 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-35084489
3.
Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells.
Glia;
70(12): 2290-2308, 2022 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-35912412
4.
A Novel Selective PKR Inhibitor Restores Cognitive Deficits and Neurodegeneration in Alzheimer Disease Experimental Models.
J Pharmacol Exp Ther;
378(3): 262-275, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34531308
5.
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation.
Acta Neuropathol;
138(4): 631-652, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31065832
6.
Systemic immune-checkpoint blockade with anti-PD1 antibodies does not alter cerebral amyloid-ß burden in several amyloid transgenic mouse models.
Glia;
66(3): 492-504, 2018 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-29134678
7.
NF-L in cerebrospinal fluid and serum is a biomarker of neuronal damage in an inducible mouse model of neurodegeneration.
Neurobiol Dis;
104: 73-84, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28392472
8.
Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway.
Biochim Biophys Acta;
1822(6): 885-96, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22306812
9.
Participating in innovative medicines initiative funded neurodegenerative disorder projects-An impact analysis conducted as part of the NEURONET project.
Front Neurol;
14: 1140722, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37006486
10.
Learnings about Aß from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics.
Acta Neuropathol Commun;
11(1): 39, 2023 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36899414
11.
The Innovative Medicines Initiative neurodegeneration portfolio: From individual projects to collaborative networks.
Front Neurol;
13: 994301, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36408524
12.
Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia.
Sci Rep;
11(1): 13462, 2021 06 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-34188106
13.
Tetravalent Bispecific Tandem Antibodies Improve Brain Exposure and Efficacy in an Amyloid Transgenic Mouse Model.
Mol Ther Methods Clin Dev;
19: 58-77, 2020 Dec 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33005703
14.
LRP1 Has a Predominant Role in Production over Clearance of Aß in a Mouse Model of Alzheimer's Disease.
Mol Neurobiol;
56(10): 7234-7245, 2019 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-31004319
15.
Gene delivery of a modified antibody to Aß reduces progression of murine Alzheimer's disease.
PLoS One;
14(12): e0226245, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31887144
16.
SAR228810: an antibody for protofibrillar amyloid ß peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA).
Alzheimers Res Ther;
10(1): 117, 2018 11 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30486882
17.
Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer's Disease.
J Alzheimers Dis;
50(2): 397-409, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-26639971
18.
In Vivo Detection of Amyloid Plaques by Gadolinium-Stained MRI Can Be Used to Demonstrate the Efficacy of an Anti-amyloid Immunotherapy.
Front Aging Neurosci;
8: 55, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27047372
19.
High-throughput 3D whole-brain quantitative histopathology in rodents.
Sci Rep;
6: 20958, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26876372
20.
SAR110894, a potent histamine H3-receptor antagonist, displays disease-modifying activity in a transgenic mouse model of tauopathy.
Alzheimers Dement (N Y);
2(4): 267-280, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-29067314