Asunto(s)
Amidas/síntesis química , Metano , Aminas , Ácidos Carboxílicos , Composición de Medicamentos , ÉsteresRESUMEN
A series of pyridinium salts derived of barbituric acid (BAC) was obtained, as starting substances in Kröhnke's reaction. On the example of 3-(1',3'-dimethyl-5'-isopropylbarbituryl-5')-1-acetonylene-N-pyrifinium bromide it was stated that the corresponding nitron can be formed only when in positions 1 and 3 of barbituric ring are no hydrogen atoms able to enolization. 3-(1',3'-Dimethyl-5'-isopropylbarbituryl-5')-pyruvic aldehyde (XIII) was obtained by decomposition of nitron XII.
Asunto(s)
Barbitúricos/síntesis química , Compuestos de Piridinio/síntesis química , Hidrazonas/síntesis química , Tiosemicarbazonas/síntesis químicaRESUMEN
In the reaction of 5,5-disubstituted barbituric acids 1-5 with DMSO mixtures of compounds with one (6, 8, 10, 12) or two methylthiomethyl groups (7, 9, 11, 13) at one or both nitrogen atom are formed. Some of obtained compounds were screened for their central action namely anticonvulsant activity.