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1.
Synthesis and determination of absolute configuration of a non-peptidic αvß6 integrin antagonist for the treatment of idiopathic pulmonary fibrosis.
Org Biomol Chem;
14(25): 5992-6009, 2016 Jul 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27226381
2.
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.
Bioorg Med Chem Lett;
22(16): 5222-6, 2012 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22801646
3.
Lead optimization using matched molecular pairs: inclusion of contextual information for enhanced prediction of HERG inhibition, solubility, and lipophilicity.
J Chem Inf Model;
50(10): 1872-86, 2010 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20873842
4.
4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.
Bioorg Med Chem Lett;
19(9): 2504-8, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19349179
5.
Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.
J Med Chem;
62(19): 8796-8808, 2019 10 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31497959
6.
Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvß6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.
J Med Chem;
62(16): 7543-7556, 2019 08 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31381331
7.
Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvß6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem;
61(18): 8417-8443, 2018 09 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-30215258
8.
Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins.
J Med Chem;
60(8): 3241-3251, 2017 04 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-28135089
9.
Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.
J Med Chem;
60(2): 722-748, 2017 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-27982588
10.
Design and synthesis of new nonsteroidal glucocorticoid modulators through application of an "agreement docking" method.
J Med Chem;
48(14): 4507-10, 2005 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-15999989
11.
Analysis of neighborhood behavior in lead optimization and array design.
J Chem Inf Model;
49(2): 195-208, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19434823
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