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1.
Proc Natl Acad Sci U S A ; 117(40): 24790-24793, 2020 10 06.
Artículo en Inglés | MEDLINE | ID: mdl-32948692

RESUMEN

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is considered a zoonotic pathogen mainly transmitted human to human. Few reports indicate that pets may be exposed to the virus. The present report describes a cat suffering from severe respiratory distress and thrombocytopenia living with a family with several members affected by COVID-19. Clinical signs of the cat prompted humanitarian euthanasia and a detailed postmortem investigation to assess whether a COVID-19-like disease was causing the condition. Necropsy results showed the animal suffered from feline hypertrophic cardiomyopathy and severe pulmonary edema and thrombosis. SARS-CoV-2 RNA was only detected in nasal swab, nasal turbinates, and mesenteric lymph node, but no evidence of histopathological lesions compatible with a viral infection were detected. The cat seroconverted against SARS-CoV-2, further evidencing a productive infection in this animal. We conclude that the animal had a subclinical SARS-CoV-2 infection concomitant to an unrelated cardiomyopathy that led to euthanasia.


Asunto(s)
Betacoronavirus/aislamiento & purificación , Cardiomiopatía Hipertrófica/veterinaria , Infecciones por Coronavirus/veterinaria , Pandemias/veterinaria , Neumonía Viral/veterinaria , Animales , COVID-19 , Cardiomiopatía Hipertrófica/patología , Cardiomiopatía Hipertrófica/virología , Gatos , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/patología , Resultado Fatal , Humanos , Hallazgos Incidentales , Neumonía Viral/complicaciones , Neumonía Viral/patología , SARS-CoV-2
2.
Vet J ; 170(2): 237-42, 2005 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-16129343

RESUMEN

The pharmacokinetics of amoxicillin (Amx) were determined in pigs following intravenous (IV) administration of a single dose of 15 mg/kg and a single dose of 15 mg/kg of a new oral formulation (Amx-FP containing 10% amoxicillin). Residue studies were performed to determine residues in edible tissues of healthy pigs after chronic oral administration of Amx-FP at a daily dose of 15 mg/kg for five consecutive days. After IV administration, the plasma concentration was characteristic of a two-compartment open model. The main pharmacokinetic variables were: t(1/2lambda(n)), MRT=90.1 min, V(darea)=0.81 L/kg and Cl(b)=3.9 mL/kg/min. After single oral administration the main pharmacokinetic variables were: C(max)=758 mug/L, t(max)=347 min and Cl(b/f)=3.7 mL/kg/min for Amx-FP. The oral bioavailability (F) was calculated at 11% for Amx-FP. Based on maximum residue levels (MRL) for AMX in pigs established at 50 microg/kg for all tissues, the withdrawal times of AMX in muscle and skin plus fat were estimated (95% tolerance limit and 95% confidence) to fall below the MRL after a withdrawal period of seven days. Levels of AMX in the liver and kidneys were estimated to fall below the MRL after a withdrawal period of four days.


Asunto(s)
Amoxicilina/administración & dosificación , Amoxicilina/farmacocinética , Antibacterianos/administración & dosificación , Antibacterianos/farmacocinética , Residuos de Medicamentos , Porcinos , Amoxicilina/sangre , Animales , Antibacterianos/sangre , Área Bajo la Curva , Esquema de Medicación , Semivida , Inyecciones Intravenosas , Distribución Tisular
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