Detalles de la búsqueda
1.
Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease.
Cell;
175(2): 372-386.e17, 2018 10 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30270042
2.
Randomized phase 1 study of the phosphatidylinositol 3-kinase δ inhibitor idelalisib in patients with allergic rhinitis.
J Allergy Clin Immunol;
137(6): 1733-1741, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26915677
3.
Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse.
J Immunol;
193(2): 544-54, 2014 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24935930
4.
Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption.
J Biol Chem;
288(49): 35346-57, 2013 Dec 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-24133210
5.
The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia.
Blood;
117(16): 4323-7, 2011 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-21378270
6.
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.
Blood;
117(2): 591-4, 2011 Jan 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-20959606
7.
The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.
Am J Physiol Lung Cell Mol Physiol;
302(11): L1179-91, 2012 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22427531
8.
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals.
Blood;
116(12): 2078-88, 2010 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-20522708
9.
PI3K/p110{delta} is a novel therapeutic target in multiple myeloma.
Blood;
116(9): 1460-8, 2010 Sep 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-20505158
10.
HIF-1α inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium.
Eur J Immunol;
40(10): 2858-69, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20827786
11.
PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation.
J Autoimmun;
36(3-4): 278-87, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21396797
12.
Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses.
J Immunol;
183(9): 5673-84, 2009 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19843950
13.
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.
J Allergy Clin Immunol;
122(4): 811-819.e2, 2008 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-19014771
14.
Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model.
FASEB J;
20(3): 455-65, 2006 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-16507763
15.
Dose-Dependent Suppression of Cytokine production from T cells by a Novel Phosphoinositide 3-Kinase Delta Inhibitor.
Sci Rep;
6: 30384, 2016 07 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-27461849
16.
Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.
J Med Chem;
59(19): 9228-9242, 2016 Oct 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27660855
17.
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.
J Med Chem;
59(7): 3532-48, 2016 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26980109
18.
B-cell receptor signaling inhibitors for treatment of autoimmune inflammatory diseases and B-cell malignancies.
Int Rev Immunol;
32(4): 397-427, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23886342
19.
Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice.
Autoimmunity;
46(1): 62-73, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23039284
20.
Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies.
Front Immunol;
3: 256, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22936933