Adherence to antihypertensive medications among family practice patients with diabetes mellitus and hypertension.

OBJECTIVE: To measure adherence and to identify factors associated with adherence to antihypertensive medications in family practice patients with diabetes mellitus (DM) and hypertension. DESIGN: A cross-sectional study using a mailed patient self-report survey and clinical data. SETTING: Twenty-seven family physician and nurse practitioner clinics from Nova Scotia, New Brunswick, and Prince Edward Island (the Maritime Family Practice Research Network). PARTICIPANTS: A total of 527 patients with type 2 DM and hypertension who had had their blood pressure measured with the BpTRU (an automated oscillometric instrument) at family practice clinic visits within the previous 6 months. MAIN OUTCOME MEASURES: Level of adherence to antihypertension medications as measured by patients' self-report on the Morisky scale; association between high adherence on the Morisky scale and 22 patient factors related to demographic characteristics, clinical variables, knowledge, beliefs, behaviour, health care provider relationships, and health system influences. RESULTS: The survey response rate was 89.6%. The average age of patients was 66 years, and 51.6% of participants were men. Forty-three percent of patients had had a diagnosis of DM for more than 10 years, and 49.7% had had a diagnosis of hypertension for more than 10 years. Eighty-nine percent of patients had some form of medical insurance. All patients had seen their family physician providers at least once within the past year. Seventy-seven percent of patients reported high adherence as measured by the Morisky scale. On multiple logistic regression, being older than 55, taking more than 7 prescribed medications, and having a lifestyle that included regular exercise or a healthy diet with low salt intake or both were significant independent predictors of high adherence scores on the Morisky scale (P ≤ .05). CONCLUSION: More than three-quarters of patients with type 2 DM and hypertension from community family practice clinics in Maritime Canada reported high adherence to their antihypertensive medications. Family physicians and nurse practitioners can apply strategies to improve antihypertensive medication adherence among type 2 DM patients who are younger, taking fewer medications, or not maintaining a lifestyle that includes regular exercise or a healthy diet or both. Future studies will need to determine whether focusing adherence strategies on these patients will improve their cardiovascular outcomes.

Assessing the feasibility of extracting clinical information to create quality indicators from primary healthcare practice EMRs.

In 2011, a panel of primary healthcare (PHC) providers in Nova Scotia rated 19 of 35 selected Canadian Institute for Health Information (2006) clinical quality indicators (QIs) as "acceptable." In this study, the authors explored the feasibility of extracting electronic medical record (EMR) data required to create these PHC QI measures.

Hypertension and type 2 diabetes: what family physicians can do to improve control of blood pressure--an observational study.

BACKGROUND: The prevalence of type 2 diabetes is rising, and most of these patients also have hypertension, substantially increasing the risk of cardiovascular morbidity and mortality. The majority of these patients do not reach target blood pressure levels for a wide variety of reasons. When a literature review provided no clear focus for action when patients are not at target, we initiated a study to identify characteristics of patients and providers associated with achieving target BP levels in community-based practice. METHODS: We conducted a practice-based, cross-sectional observational and mailed survey study. The setting was the practices of 27 family physicians and nurse practitioners in 3 eastern provinces in Canada. The participants were all patients with type 2 diabetes who could understand English, were able to give consent, and would be available for follow-up for more than one year. Data were collected from each patient's medical record and from each patient and physician/nurse practitioner by mailed survey. Our main outcome measures were overall blood pressure at target (< 130/80), systolic blood pressure at target, and diastolic blood pressure at target. Analysis included initial descriptive statistics, logistic regression models, and multivariate regression using hierarchical nonlinear modeling (HNLM). RESULTS: Fifty-four percent were at target for both systolic and diastolic pressures. Sixty-two percent were at systolic target, and 79% were at diastolic target. Patients who reported eating food low in salt had higher odds of reaching target blood pressure. Similarly, patients reporting low adherence to their medication regimen had lower odds of reaching target blood pressure. CONCLUSIONS: When primary care health professionals are dealing with blood pressures above target in a patient with type 2 diabetes, they should pay particular attention to two factors. They should inquire about dietary salt intake, strongly emphasize the importance of reduction, and refer for detailed counseling if necessary. Similarly, they should inquire about adherence to the medication regimen, and employ a variety of patient-oriented strategies to improve adherence.

Self-reported health beliefs, lifestyle and health behaviours in community-based patients with diabetes and hypertension.

OBJECTIVE: This study describes self-reported health and lifestyle behaviours and health risk beliefs among community patients diagnosed with type 2 diabetes and hypertension. METHODS: Patients with both type 2 diabetes and hypertension were recruited from community family practices across 3 Canadian Maritime provinces. Patients completed a survey targeting health risk beliefs, and health and lifestyle behaviours. Analyses examined differences in patient beliefs by age and sex, as well by health and lifestyle behaviour. RESULTS: Overall, 90.8% of patients believed that controlling both blood pressure and blood glucose were important, particularly women (p<0.01), and 92.8% felt that having both conditions put them at high risk for cardiovascular problems. Older patients reported higher antihypertensive medication adherence (p<0.0001). Most (90.8%) believed that prescription drug use was most helpful for controlling blood pressure, and this belief was associated with medication adherence (p<0.0001). Overall, patients who believed in the benefits of a given lifestyle behaviour were more likely to demonstrate the behaviour. CONCLUSION: The majority of patients surveyed were knowledgeable about their increased risk for cardiovascular problems. Patient lifestyle behaviours tended to mirror their health beliefs. These results provide important insight into the health beliefs and lifestyle behaviours of patients who receive the majority of their care in the community.

Ethics and privacy issues of a practice-based surveillance system: need for a national-level institutional research ethics board and consent standards.

OBJECTIVE: To describe the challenges the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) experienced with institutional research ethics boards (IREBs) when seeking approvals across jurisdictions and to provide recommendations for overcoming challenges of ethical review for multisite and multijurisdictional surveillance and research. BACKGROUND: The CPCSSN project collects and validates longitudinal primary care health information (relating to hypertension, diabetes, depression, chronic obstructive lung disease, and osteoarthritis) from electronic medical records across Canada. Privacy and data storage security policies and processes have been developed to protect participants' privacy and confidentiality, and IREB approval is obtained in each participating jurisdiction. Inconsistent interpretation and application of privacy and ethical issues by IREBs delays and impedes research programs that could better inform us about chronic disease. RESULTS: The CPCSSN project's experience with gaining approval from IREBs highlights the difficulty of conducting pan-Canadian health surveillance and multicentre research. Inconsistent IREB approvals to waive explicit individual informed consent produced particular challenges for researchers. CONCLUSION: The CPCSSN experience highlights the need to develop a better process for researchers to obtain timely and consistent IREB approvals for multicentre surveillance and research. We suggest developing a specialized, national, centralized IREB responsible for approving multisite studies related to population health research.

Trends in risk factors for cardiovascular disease in Canada: temporal, socio-demographic and geographic factors.

BACKGROUND: Temporal trends in risk factors for cardiovascular disease and the impact of socio-economic status on these risk factors remain unclear. METHODS: Using data from the National Population Health Survey and the Canadian Community Health Survey, we examined national trends in heart disease, hypertension, diabetes mellitus, obesity and smoking prevalence from 1994 to 2005, adjusting for age and sex. We stratified data by income adequacy category, body mass index and region of residence. RESULTS: An estimated 1.29 million Canadians reported having heart disease in 2005, representing increases of 19% for men and 2% for women, relative to 1994. Heart disease increased significantly in the lowest income category (by 27%), in the lower middle income category (by 37%) and in the upper middle income category (by 12%); however, it increased by only 6% in the highest income group. Diabetes increased in all but the highest income group: by 56% in the lowest income group, by 93% in the lower middle income group and by 59% in the upper middle income group. Hypertension increased in all income groups: by 85% in the lowest income group, by 80% in the lower middle income group, by 91% in the upper middle income group and by 117% in the highest income group. Obesity also increased in all income groups: by 20% in the lowest income group, by 25% in the lower middle income group, by 33% in the upper middle income group and by 37% in the highest income group. In addition to socio-economic status, obesity and overweight also modified the trends in risk factors. Diabetes increased to a greater extent among obese participants (61% increase) and overweight participants (25% increase), as did hypertension, which increased by 80% among obese individuals and by 74% among overweight individuals. Trends in diabetes, hypertension and obesity were consistent for all provinces. INTERPRETATION: During the study period, heart disease, hypertension, diabetes and obesity increased for all or most income groups in Canada. Further interventions supporting modification of lifestyle and risk factors are needed to prevent future cardiovascular disease.

Drug management for hypertension in type 2 diabetes in family practice.

OBJECTIVE: To describe the number and classes of antihypertensive medications prescribed to patients with type 2 diabetes in community family practices, and to estimate the aggressiveness or "dosage intensity" of prescribing for hypertension in these situations. DESIGN: Practice-based, cross-sectional observational study. SETTING: Seventeen rural and urban family practices in the Maritime Family Practice Research Network in Nova Scotia, New Brunswick, and Prince Edward Island. PARTICIPANTS: A total of 670 patients with type 2 diabetes, ranging from 25 to 92 years of age. MAIN OUTCOME MEASURES: Number, classes, and combinations of classes of antihypertensive medications prescribed, as well as an index of each medication's dosage intensity. RESULTS: Almost 80% of patients studied had hypertension. Participants with hypertension were taking an average of 2.5 medications, and 47.6% were taking 3 or more antihypertensive medications, but only 27.1% reached target blood pressure values of less than 130/80 mm Hg. Older patients took more antihypertensive medications, but there were no differences by sex. More than 90% were taking angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, 66% were taking diuretics, 41% were taking beta-blockers, and 38% were taking calcium channel blockers. We cannot describe the sequence in which antihypertensive medication classes were added, but analysis of patients taking multiple drug classes suggests that most patients were started on angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, followed by diuretics, beta-blockers, or calcium channel blockers. The most commonly used medications were prescribed at higher than two-thirds the maximum dose effective for hypertension. CONCLUSION: Hypertension is very common among family practice patients with type 2 diabetes; of those patients, few reach target blood pressures. Practice-based strategies to increase dosing and number of medications prescribed might be required.

Quality indicators for cardiovascular primary care.

BACKGROUND: The Canadian Cardiovascular Outcomes Research Team was established in 2001 to improve the quality of cardiovascular care for Canadians. Initially, quality indicators (QIs) for hospital-based care for those with acute myocardial infarctions and congestive heart failure were developed and measured. Qualitative research on the acceptability of those indicators concluded that indicators were needed for ambulatory primary care practice, where the bulk of cardiovascular disease care occurs. OBJECTIVES: To systematically develop QIs for primary care practice for the primary prevention and chronic disease management of ischemic heart disease, hypertension, hyperlipidemia and heart failure. METHODS: A four-stage modified Delphi approach was used and included a literature review of evidence-based practice guidelines and previously developed QIs; the development and circulation of a survey tool with proposed QIs, asking respondents to rate each indicator for validity, necessity to record and feasibility to collect; an in-person meeting of respondents to resolve rating and content discrepancies, and suggest additional QIs; and recirculation of the survey tool for rating of additional QIs. Participants from across Canada included family physicians, primary care nurses, an emergency room family physician and cardiologists. RESULTS: 31 QIs were agreed on, nine of which were for primary prevention and 22 of which were for chronic disease management. CONCLUSIONS: A core set of QIs for ambulatory primary care practice has been developed as a tool for practitioners to evaluate the quality of cardiovascular disease care. While the participants rated the indicators as feasible to collect, the next step will be to conduct field validation.

Quality indicators for cardiac care: national standards in a community context.

OBJECTIVE: Public reporting of health data is well established in the United States and in the United Kingdom, and is assumed to promote better health care through informed choice by consumers. To be successful, reporting systems must have the support of physicians, but their opinions have been mixed. The purpose of this study was to explore with practising physicians the perceived usefulness of, and barriers to use of, quality indicators in the care of acute myocardial infarction and congestive heart failure, and the contexts in which these issues arise. METHODS: Six focus groups were conducted in small-, medium- and large-sized communities in two provinces in Canada. Subjects were family physicians, emergency physicians, internists and cardiologists. Data were analysed inductively. RESULTS: Our participants were generally supportive of the quality indicators, with concerns expressed regarding interpretation of data from measures created by "experts" but applied in the context of community hospitals and community-based practice. Content analysis disclosed that a majority of the indicators was acceptable; few were outright unacceptable. Inductive analysis revealed two contextual concerns: issues arising from the structure and organization of the health care system, such as equitable access to health care resources and discontinuity or fragmentation of the system, and patient-related issues, such as compliance with medications post-discharge and costs of medications. CONCLUSIONS: There is general support for this set of quality indicators, with the caveat that data should be carefully interpreted in the context of each community in which they are applied.

Population-based evaluation of the management of antithrombotic therapy for atrial fibrillation.

BACKGROUND: Oral anticoagulation is an effective therapy for the prevention of cardioembolic complications in patients with atrial fibrillation. However, previous practice reviews have indicated that oral anticoagulants are often underused in this setting. Most of those reports have focused on reviews of hospitalized and institutionalized patients, or small geographical areas. OBJECTIVES: To determine the use of antithrombotic therapy for the treatment of atrial fibrillation in Nova Scotia and to survey the knowledge of antithrombotic therapy for atrial fibrillation among a concurrent cohort of primary care and specialist physicians involved in the management of patients with atrial fibrillation. PATIENTS AND METHODS: Patients with atrial fibrillation were identified through outpatient electrocardiography clinics held throughout Nova Scotia. Following consent of the primary care physicians, patients were contacted and completed a survey about their current management. Family physicians and specialists in Nova Scotia were also surveyed about the management of atrial fibrillation with antithrombotic therapy through the receipt of one of four case scenarios. RESULTS: Four hundred twenty-five patients participated in the cross-sectional survey. The mean patient age was 70.6 years, 255 (60%) were male and 398 (93.6%) had at least one risk factor for stroke in addition to atrial fibrillation. Two hundred ninety-four patients (69.2%) were receiving oral anticoagulants either alone (61.9%) or in combination with acetylsalicylic acid (ASA) (7.3%). An additional 85 patients (20%) received ASA alone. There was no difference in the rates of prescription of oral anticoagulants between elderly patients (75 years of age and older) and those younger than 75 years (71.7% versus 67.3%, 95% CI -13.1% to 4.5%; P=0.34). Overall, 72.0% of patients were receiving antithrombotic therapy in accordance with the 2001 guidelines of the American College of Chest Physicians, with no difference in the rates between individuals younger than 75 years (72.2%) and those over 75 years of age (71.7%) (absolute difference -0.5%, 95% CI -9.2% to 8.1%). Physician responses to case scenarios indicated that knowledge was high among both general practitioners and specialists regarding the appropriate use of oral anticoagulants for the prevention of thrombotic complications associated with atrial fibrillation. CONCLUSIONS: The appropriate use of oral antithrombotic therapy for the prevention of thrombotic complications of atrial fibrillation occurs in approximately 72% of patients studied in Nova Scotia, and physician knowledge about this indication is high. There was no bias against prescribing oral anticoagulants to elderly patients. The findings suggest that with time, education and evidence have positively impacted the use of antithrombotic therapy in these patients.

Stroke prevention in hospitalized patients with atrial fibrillation: a population-based study.

BACKGROUND: Oral anticoagulants reduce the incidence of stroke by 68%, yet suboptimal use has been documented in surveys of patients with atrial fibrillation. The present study examined current patterns of anticoagulant use for patients hospitalized with atrial fibrillation across an entire health care system. METHODS: Improving Cardiovascular Outcomes in Nova Scotia (ICONS) is a prospective cohort study involving all patients hospitalized in Nova Scotia with atrial fibrillation, among other conditions. Consecutive inpatients with atrial fibrillation from October 15, 1997 to October 14, 1998 were studied. Detailed demographic and clinical data were collected and the proportion of patients using antithrombotic therapy was tabulated by risk category. Multivariate logistic regression was used to assess the relationship of various demographic and clinical factors with the use of antithrombotic agents. RESULTS: There were 2202 patients hospitalized with atrial fibrillation; 644 admitted specifically for this condition. Only 21% of patients admitted with atrial fibrillation were on warfarin sodium at admission and this increased by time of discharge. Diabetes was negatively correlated with warfarin sodium use. Histories of prosthetic valve replacement, stroke/transient ischemic attack, and heart failure were positively associated with anticoagulant use on admission. Patients with prosthetic valve replacement, heart failure, or hyperlipidemia were most likely to receive anticoagulants at discharge. CONCLUSION: Antithrombotic agents remain underused by patients with atrial fibrillation. While higher risk patients are generally targeted, this is not invariably the case; thus, diabetics remain under treated. Further work is needed to explain such anomalous practice and promote optimal antithrombotic therapy use.

Evidence-based cardiovascular care in the community: a population-based cross-sectional study.

BACKGROUND: Ischaemic heart disease and congestive heart failure are common and important conditions in family practice. Effective treatments may be underutilized, particularly in women and the elderly. The objective of the study was to determine the rate of prescribing of evidence-based cardiovascular medications and determine if these differed by patient age or sex. METHODS: We conducted a two-year cross-sectional study involving all hospitals in the province of Nova Scotia, Canada. Subjects were all patients admitted with ischaemic heart disease with or without congestive heart failure between 15 October 1997 and 14 October 1999. The main measure was the previous outpatient use of recommended medications. Chi-square analyses followed by multivariate logistic regression analyses were used to examine age-sex differences. RESULTS: Usage of recommended medications varied from approximately 60% for beta-blockers and angiotensin converting enzyme (ACE) inhibitors to 90% for antihypertensive agents. Patients aged 75 and over were significantly less likely than younger patients to be taking any of the medication classes. Following adjustment for age, there were no significant differences in medication use by sex except among women aged 75 and older who were more likely to be taking beta-blockers than men in the same age group. CONCLUSIONS: The use of evidence-based cardiovascular medications is rising and perhaps approaching reasonable levels for some drug classes. Family physicians should ensure that all eligible patients (prior myocardial infarction, congestive failure) are offered beta-blockers or ACE inhibitors.

Assessing the acceptability of quality indicators and linkages to payment in primary care in nova scotia.

In 2006, the Canadian Institute for Health Information (CIHI) released a comprehensive set of quality indicators (QIs) for primary healthcare (PHC). We explored the acceptability of a subset of these as measures of the technical quality of care and the potential link to payment incentive tools. A modified Delphi approach, based on the RAND consensus panel method, was used with an expert panel composed of PHC providers (family physicians, nurses and nurse practitioners) and decision-makers with no previous experience of "pay for performance." A nine-point Likert scale was used to rate the acceptability of 35 selected CIHI QIs in community practice and the acceptability of a payment mechanism associated with each. QIs rated with disagreement were discussed and re-rated in a face-to-face meeting. The panel rated 19 QIs as "acceptable." Payment incentives associated with these QIs were acceptable for 13. Several factors emerged that were common to the less appealing QIs with respect to payment linkage.

What influences seniors' choice of medications for osteoarthritis? Qualitative inquiry.

OBJECTIVE: To explore with seniors what influences their choice of medication for osteoarthritis. DESIGN: Qualitative study using semistructured in-depth interviews. SETTING: Interviews were conducted in patients' homes in two cities in Nova Scotia. PARTICIPANTS: Seniors with a physician-confirmed diagnosis of osteoarthritis. METHOD: Interviews were audiotaped and transcribed verbatim. A grounded-theory approach was used. Key words and phrases were identified independently by all members of the research team who then collectively grouped the data into conceptual categories. MAIN FINDINGS: Four themes emerged from discussions about medication choices: the role of family physicians in influencing use of cyclooxygenase-2 inhibitors, the effect of fear of making medication choices, the reasons for discontinuing cyclooxygenase-2 inhibitors, and views on other information sources. Distribution of free samples, family physicians' recommendations, and fear of side effects influenced seniors' choices of osteoarthritis medications. They claimed not to be influenced by direct-to-consumer advertising or the fact that cyclooxygenase-2 inhibitors are more expensive than other classes of drugs for osteoarthritis. CONCLUSION: Because seniors' choice of medications for osteoarthritis is often influenced by physicians' recommendations and distribution of free samples, further research into how distribution of free samples affects medication choices in family practice is needed.

Potential for drug interactions in seniors with osteoarthritis.

OBJECTIVE: To document the potential for drug interactions in seniors with osteoarthritis and to consider the usefulness of computerized support for detecting clinically important interactions. DESIGN: Self-administered mailed survey. One question requested a list of all medications (prescribed drugs and self-care products, including herbal and "natural" health products) taken in the last 7 days. Interactions among all medications were assessed using an on-line software package. SETTING: Three urban primary care practices in Nova Scotia. PARTICIPANTS: Questionnaires were sent to 244 patients aged 65 years and older with physician-confirmed osteoarthritis. MAIN OUTCOME MEASURES: Number of potential interactions and level of clinical significance associated with each. RESULTS: Response rate was 78% (n = 191); 174 respondents (92%) supplied information on medications. Respondents took an average of 4.7 products of which 2.8 were prescription medications and 1.9 were self-care products. A total of 214 potential interactions were identified; 30 (14%) of these were clinically significant. Most interactions involved nonprescription products, most frequently acetylsalicylic acid. Recommendations in 29 of these 30 clinically significant interactions were cautionary, advising such measures as closer monitoring of blood tests, observation for toxic effects, or making patients aware of side effects. Only 1 interaction prompted a recommendation for avoidance. Respondents reported use of 7 different herbal and natural health products; these products were associated with 5 clinically insignificant interactions. CONCLUSION: Risk of drug interactions in seniors might be high, but few interactions are clinically significant. Only 1 found in our study carried a recommendation for avoidance. The on-line program reported all significant interactions, but the high proportion of insignificant interactions (6 : 1) also reported could lead physicians to override computer-generated alerts.

Group interviews in primary care research: advancing the state of the art or ritualized research?

BACKGROUND: Focus groups have become an important data gathering technique in primary care research. OBJECTIVES: This study provides an integrated review of recent articles that used focus groups as a data collection method to gather information from family physicians. METHODS: Medline was searched for articles that used focus groups with family physicians in a North American setting during the 1990s. Articles that met this criteria were critically evaluated to determine who participated, the number of groups conducted, setting, length, inclusion and exclusion criteria, sampling technique and whether the groups were used as part of a larger study. RESULTS: The twenty articles discussed herein revealed tremendous variation in how focus group research is conducted and reported. CONCLUSIONS: Focus group research is a popular form of qualitative research in primary care research. Journals reporting qualitative research should require that certain basic information be present, thereby advancing the state of the art and permitting readers to better evaluate these articles.

Evidence-based cardiovascular care. Family physicians' views of obstacles and opportunities.

OBJECTIVE: To explore obstacles to and opportunities for applying specific lifestyle and pharmacologic recommendations on chronic ischemic heart disease. DESIGN: Qualitative study. SETTING: Rural, town, and city settings in Nova Scotia. PARTICIPANTS: Fifty family physicians caring for patients with cardiovascular (CV) disease. METHOD: Nine focus groups were conducted, audiotaped, and transcribed. Seven recommendations had been selected for discussion based on their relevance to primary care, strength, and class of supporting evidence. Analysis was guided by grounded-theory methodology. MAIN FINDINGS: "Ischemic events" can be powerful motivators for change, whereas the asymptomatic nature of CV risks and distant outcomes can form obstacles. Trust built through previous experiences and the opportunity to repeat important messages can facilitate application of evidence, but patient-physician relationships can also pose obstacles. CONCLUSION: Physicians can take steps to improve care, but success at reducing CV risks depends upon active involvement of many health professionals and community resources. Future guideline implementation should focus on patient-oriented issues, such as comorbidity and treatment preferences.

Managing osteoarthritis. Medication use among seniors in the community.

OBJECTIVE: To determine what types of medication seniors in the community were using to manage osteoarthritis (OA). DESIGN: Mailed self-administered survey. SETTING: Three family medicine community practice sites in cities in Nova Scotia. PARTICIPANTS: All seniors (aged 65 and older) on the electronic record of each practice site with a physician-confirmed diagnosis of OA (N = 244). MAIN OUTCOME MEASURES: Proportion of seniors using prescribed medications or self-care products (nonprescribed medications and herbal and natural health products) for OA. RESULTS: Response rate was 78%. About 15% were using no medication, 74% were using at least one type of self-care product (60% were using nonprescribed medications, and 45% were using herbal and natural health products), and 52% were using prescribed medications alone or in combination with self-care products. CONCLUSION: Seniors' use of prescribed and self-care products for OA is very high. Physicians must be aware that patients seeking prescriptions likely are also using self-care products. The potential for drug interactions is high; patients should be made aware of the risks associated with taking multiple products.