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1.

A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells.

Tieu, Victor; Sotillo, Elena; Bjelajac, Jeremy R; Chen, Crystal; Malipatlolla, Meena; Guerrero, Justin A; Xu, Peng; Quinn, Patrick J; Fisher, Chris; Klysz, Dorota; Mackall, Crystal L; Qi, Lei S.

Cell; 187(5): 1278-1295.e20, 2024 Feb 29.

Artículo en Inglés | MEDLINE | ID: mdl-38387457

2.

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.

Abbott, Timothy R; Dhamdhere, Girija; Liu, Yanxia; Lin, Xueqiu; Goudy, Laine; Zeng, Leiping; Chemparathy, Augustine; Chmura, Stephen; Heaton, Nicholas S; Debs, Robert; Pande, Tara; Endy, Drew; La Russa, Marie F; Lewis, David B; Qi, Lei S.

Cell; 181(4): 865-876.e12, 2020 05 14.

Artículo en Inglés | MEDLINE | ID: mdl-32353252

3.

CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization.

Wang, Haifeng; Xu, Xiaoshu; Nguyen, Cindy M; Liu, Yanxia; Gao, Yuchen; Lin, Xueqiu; Daley, Timothy; Kipniss, Nathan H; La Russa, Marie; Qi, Lei S.

Cell; 175(5): 1405-1417.e14, 2018 11 15.

Artículo en Inglés | MEDLINE | ID: mdl-30318144

4.

CRISPR/Cas9 in Genome Editing and Beyond.

Wang, Haifeng; La Russa, Marie; Qi, Lei S.

Annu Rev Biochem; 85: 227-64, 2016 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-27145843

5.

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

Qi, Lei S; Larson, Matthew H; Gilbert, Luke A; Doudna, Jennifer A; Weissman, Jonathan S; Arkin, Adam P; Lim, Wendell A.

Cell; 184(3): 844, 2021 Feb 04.

Artículo en Inglés | MEDLINE | ID: mdl-33545038

6.

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.

Peters, Jason M; Colavin, Alexandre; Shi, Handuo; Czarny, Tomasz L; Larson, Matthew H; Wong, Spencer; Hawkins, John S; Lu, Candy H S; Koo, Byoung-Mo; Marta, Elizabeth; Shiver, Anthony L; Whitehead, Evan H; Weissman, Jonathan S; Brown, Eric D; Qi, Lei S; Huang, Kerwyn Casey; Gross, Carol A.

Cell; 165(6): 1493-1506, 2016 Jun 02.

Artículo en Inglés | MEDLINE | ID: mdl-27238023

7.

Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing.

Chang, Howard Y; Qi, Lei S.

Mol Cell; 83(3): 442-451, 2023 02 02.

Artículo en Inglés | MEDLINE | ID: mdl-36736311

8.

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.

Zalatan, Jesse G; Lee, Michael E; Almeida, Ricardo; Gilbert, Luke A; Whitehead, Evan H; La Russa, Marie; Tsai, Jordan C; Weissman, Jonathan S; Dueber, John E; Qi, Lei S; Lim, Wendell A.

Cell; 160(1-2): 339-50, 2015 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-25533786

9.

A protein-tagging system for signal amplification in gene expression and fluorescence imaging.

Tanenbaum, Marvin E; Gilbert, Luke A; Qi, Lei S; Weissman, Jonathan S; Vale, Ronald D.

Cell; 159(3): 635-46, 2014 Oct 23.

Artículo en Inglés | MEDLINE | ID: mdl-25307933

10.

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Gilbert, Luke A; Horlbeck, Max A; Adamson, Britt; Villalta, Jacqueline E; Chen, Yuwen; Whitehead, Evan H; Guimaraes, Carla; Panning, Barbara; Ploegh, Hidde L; Bassik, Michael C; Qi, Lei S; Kampmann, Martin; Weissman, Jonathan S.

Cell; 159(3): 647-61, 2014 Oct 23.

Artículo en Inglés | MEDLINE | ID: mdl-25307932

11.

Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing.

Xu, Xiaoshu; Chemparathy, Augustine; Zeng, Leiping; Kempton, Hannah R; Shang, Stephen; Nakamura, Muneaki; Qi, Lei S.

Mol Cell; 81(20): 4333-4345.e4, 2021 10 21.

Artículo en Inglés | MEDLINE | ID: mdl-34480847

12.

Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9.

Gao, Yuchen; Han, Mengting; Shang, Stephen; Wang, Haifeng; Qi, Lei S.

Mol Cell; 81(20): 4287-4299.e5, 2021 10 21.

Artículo en Inglés | MEDLINE | ID: mdl-34428454

13.

Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation.

Dominguez, Antonia A; Lim, Wendell A; Qi, Lei S.

Nat Rev Mol Cell Biol; 17(1): 5-15, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26670017

14.

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

Qi, Lei S; Larson, Matthew H; Gilbert, Luke A; Doudna, Jennifer A; Weissman, Jonathan S; Arkin, Adam P; Lim, Wendell A.

Cell; 152(5): 1173-83, 2013 Feb 28.

Artículo en Inglés | MEDLINE | ID: mdl-23452860

15.

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.

Chen, Baohui; Gilbert, Luke A; Cimini, Beth A; Schnitzbauer, Joerg; Zhang, Wei; Li, Gene-Wei; Park, Jason; Blackburn, Elizabeth H; Weissman, Jonathan S; Qi, Lei S; Huang, Bo.

Cell; 155(7): 1479-91, 2013 Dec 19.

Artículo en Inglés | MEDLINE | ID: mdl-24360272

16.

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

Gilbert, Luke A; Larson, Matthew H; Morsut, Leonardo; Liu, Zairan; Brar, Gloria A; Torres, Sandra E; Stern-Ginossar, Noam; Brandman, Onn; Whitehead, Evan H; Doudna, Jennifer A; Lim, Wendell A; Weissman, Jonathan S; Qi, Lei S.

Cell; 154(2): 442-51, 2013 Jul 18.

Artículo en Inglés | MEDLINE | ID: mdl-23849981

17.

Multiple Input Sensing and Signal Integration Using a Split Cas12a System.

Kempton, Hannah R; Goudy, Laine E; Love, Kasey S; Qi, Lei S.

Mol Cell; 78(1): 184-191.e3, 2020 04 02.

Artículo en Inglés | MEDLINE | ID: mdl-32027839

18.

Engineering 3D genome organization.

Wang, Haifeng; Han, Mengting; Qi, Lei S.

Nat Rev Genet; 22(6): 343-360, 2021 06.

Artículo en Inglés | MEDLINE | ID: mdl-33558716

19.

Site-Programmable Transposition: Shifting the Paradigm for CRISPR-Cas Systems.

Chavez, Michael; Qi, Lei S.

Mol Cell; 75(2): 206-208, 2019 07 25.

Artículo en Inglés | MEDLINE | ID: mdl-31348878

20.

Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.

Shariati, S Ali; Dominguez, Antonia; Xie, Shicong; Wernig, Marius; Qi, Lei S; Skotheim, Jan M.

Mol Cell; 74(3): 622-633.e4, 2019 05 02.

Artículo en Inglés | MEDLINE | ID: mdl-31051141

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A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells.

Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza.

CRISPR-Mediated Programmable 3D Genome Positioning and Nuclear Organization.

CRISPR/Cas9 in Genome Editing and Beyond.

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.

Reversing the Central Dogma: RNA-guided control of DNA in epigenetics and genome editing.

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.

A protein-tagging system for signal amplification in gene expression and fluorescence imaging.

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.

Engineered miniature CRISPR-Cas system for mammalian genome regulation and editing.

Interrogation of the dynamic properties of higher-order heterochromatin using CRISPR-dCas9.

Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation.

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

Multiple Input Sensing and Signal Integration Using a Split Cas12a System.

Engineering 3D genome organization.

Site-Programmable Transposition: Shifting the Paradigm for CRISPR-Cas Systems.

Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9.