Double-branch U-Net for multi-scale organ segmentation.

U-Net has achieved great success in the task of medical image segmentation. It encodes and extracts information from several convolution blocks, and then decodes the feature maps to get the segmentation results. Our experiments show that in a multi-scale medical segmentation task, excessive downsampling will cause the model to ignore the small segmentation objects and thus fail to complete the segmentation task. In this work, we propose a more complete method Double-branch U-Net (2BUNet) to solve the multi-scale organ segmentation challenge. Our model is divided into four parts: main branch, tributary branch, information exchange module and classification module. The main advantages of the new model consist of: (1) Extracting information to improve model decoding capabilities using the complete encoding structure. (2) The information exchange module is added to the main branch and tributaries to provide regularization for the model, so as to avoid the large gap between the two paths. (3) Main branch structure for extracting major features of large organ. (4) The tributary structure is used to enlarge the image to extract the microscopic characteristics of small organ. (5) A classification assistant module is proposed to increase the class constraint for the output tensor. The comparative experiments show that our method achieves state-of-the-art performances in real scenes.

Cuff-Less Blood Pressure Prediction Based on Photoplethysmography and Modified ResNet.

Cardiovascular disease (CVD) has become a common health problem of mankind, and the prevalence and mortality of CVD are rising on a year-to-year basis. Blood pressure (BP) is an important physiological parameter of the human body and also an important physiological indicator for the prevention and treatment of CVD. Existing intermittent measurement methods do not fully indicate the real BP status of the human body and cannot get rid of the restraining feeling of a cuff. Accordingly, this study proposed a deep learning network based on the ResNet34 framework for continuous prediction of BP using only the promising PPG signal. The high-quality PPG signals were first passed through a multi-scale feature extraction module after a series of pre-processing to expand the perceptive field and enhance the perception ability on features. Subsequently, useful feature information was then extracted by stacking multiple residual modules with channel attention to increase the accuracy of the model. Lastly, in the training stage, the Huber loss function was adopted to stabilize the iterative process and obtain the optimal solution of the model. On a subset of the MIMIC dataset, the errors of both SBP and DBP predicted by the model met the AAMI standards, while the accuracy of DBP reached Grade A of the BHS standard, and the accuracy of SBP almost reached Grade A of the BHS standard. The proposed method verifies the potential and feasibility of PPG signals combined with deep neural networks in the field of continuous BP monitoring. Furthermore, the method is easy to deploy in portable devices, and it is more consistent with the future trend of wearable blood-pressure-monitoring devices (e.g., smartphones and smartwatches).

BARN: Behavior-Aware Relation Network for multi-label behavior detection in socially housed macaques.

Quantification of behaviors in macaques provides crucial support for various scientific disciplines, including pharmacology, neuroscience, and ethology. Despite recent advancements in the analysis of macaque behavior, research on multi-label behavior detection in socially housed macaques, including consideration of interactions among them, remains scarce. Given the lack of relevant approaches and datasets, we developed the Behavior-Aware Relation Network (BARN) for multi-label behavior detection of socially housed macaques. Our approach models the relationship of behavioral similarity between macaques, guided by a behavior-aware module and novel behavior classifier, which is suitable for multi-label classification. We also constructed a behavior dataset of rhesus macaques using ordinary RGB cameras mounted outside their cages. The dataset included 65 913 labels for 19 behaviors and 60 367 proposals, including identities and locations of the macaques. Experimental results showed that BARN significantly improved the baseline SlowFast network and outperformed existing relation networks. In conclusion, we successfully achieved multi-label behavior detection of socially housed macaques with both economic efficiency and high accuracy.

Advances in Cuffless Continuous Blood Pressure Monitoring Technology Based on PPG Signals.

Objective: To review the progress of research on photoplethysmography- (PPG-) based cuffless continuous blood pressure monitoring technologies and prospect the challenges that need to be addressed in the future. Methods: Using Web of Science and PubMed as search engines, the literature on cuffless continuous blood pressure studies using PPG signals in the recent five years were searched. Results: Based on the retrieved literature, this paper describes the available open datasets, commonly used signal preprocessing methods, and model evaluation criteria. Early researches employed multisite PPG signals to calculate pulse wave velocity or time and predicted blood pressure by a simple linear equation. Later, extensive researches were dedicated to mine the features of PPG signals related to blood pressure and regressed blood pressure by machine learning models. Most recently, many researches have emerged to experiment with complex deep learning models for blood pressure prediction with the raw PPG signal as input. Conclusion: This paper summarized the methods in the retrieved literature, provided insight into the artificial intelligence algorithms employed in the literature, and concluded with a discussion of the challenges and opportunities for the development of cuffless continuous blood pressure monitoring technologies.

Application of Artificial Intelligence in Diagnosis of Craniopharyngioma.

Craniopharyngioma is a congenital brain tumor with clinical characteristics of hypothalamic-pituitary dysfunction, increased intracranial pressure, and visual field disorder, among other injuries. Its clinical diagnosis mainly depends on radiological examinations (such as Computed Tomography, Magnetic Resonance Imaging). However, assessing numerous radiological images manually is a challenging task, and the experience of doctors has a great influence on the diagnosis result. The development of artificial intelligence has brought about a great transformation in the clinical diagnosis of craniopharyngioma. This study reviewed the application of artificial intelligence technology in the clinical diagnosis of craniopharyngioma from the aspects of differential classification, prediction of tissue invasion and gene mutation, prognosis prediction, and so on. Based on the reviews, the technical route of intelligent diagnosis based on the traditional machine learning model and deep learning model were further proposed. Additionally, in terms of the limitations and possibilities of the development of artificial intelligence in craniopharyngioma diagnosis, this study discussed the attentions required in future research, including few-shot learning, imbalanced data set, semi-supervised models, and multi-omics fusion.