RESUMEN
BACKGROUND & OBJECTIVE: Recent meta-analysis reports have called for more randomized trials to evaluate the effectiveness of GIK solution in patients of cardiac surgery. So this study was conducted to evaluate the effectiveness of Glucose-insulin-potassium (GIK) solutions in non-diabetic patients undergoing coronary artery bypass grafting. METHODS: A total number of one hundred and sixty (160) patients were randomized into two equal groups; GIK Group and non-GIK group. In GIK group, 5% dextrose containing 70 IU/L regular insulin and 70 meq/L of potassium was administered. The infusion was started at a rate of 30 ml/hour after induction of anesthesia and before the start of cardiopulmonary bypass. The infusion was started again after removal of aortic cross clamp and was continued for six hours after the operation. RESULTS: In early post-operative period, peak CKMB levels were high in non-GIK group 48.50±19.79 IU/L versus 33.40±14.69 IU/L in GIK group (p-value <0.001). There was no statistically significant difference in requirements of inotropic support between the groups. The mean duration of inotropic support in GIK group was only 5.50±6.88 hours in GIK group and 8.64±7.74 hours in non-GIK group (p-value 0.008). Mean ventilation time in GIK group was 5.06±2.39 hours versus 6.55±3.58 hours in non-GIK group (p-value 0.002). Similarly, ICU stay period was also shorter in GIK group (p-value 0.01). We did not found any detrimental effect of GIK infusion on non-cardiac complications e.g. renal, pulmonary and neurologic complications. CONCLUSION: Glucose-insulin-potassium (GIK) infusion has a beneficial role in myocardial protection and is associated with better post-operative outcomes without increasing the risk of non-cardiac complications.
RESUMEN
BACKGROUND: Obesity is an independent factor implicated in left ventricular (LV) hypertrophy and increased left ventricular mass. Early detection of increased LV mass in obese patients has prognostic and therapeutic implications. METHODS: This case series was carried out in Choudhry Pervaiz Ellahi Institute of Cardiology, Multan from March to August 2011. A total of 100 consecutive patients including male and female referred for transthoracic echocardiography were included in this study. Patient's demographics were obtained using a questionnaire. Anthropometry (BMI) and two-dimensional echocardiography to calculate LV mass. RESULTS: Echocardiograms of 100 patients showing mean age 42.42 ± 6.04 years, with BMI of 28.42 ± 5.52 and LV Mass of 136.05 ± 29.117 shown linear correlation between BMI and LV mass. CONCLUSION: In is concluded from the study that LV mass increases with increasing BMI.