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1.
Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission.
Stem Cells;
26(8): 2153-63, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18535156
2.
Novel 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamide transition state peptidomimetics are potent and orally active inhibitors of human renin.
J Med Chem;
50(20): 4818-31, 2007 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17824679
3.
Structural modification of the P2' position of 2,7-dialkyl-substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides: the discovery of aliskiren, a potent nonpeptide human renin inhibitor active after once daily dosing in marmosets.
J Med Chem;
50(20): 4832-44, 2007 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17824680
4.
Structure-based design of aliskiren, a novel orally effective renin inhibitor.
Biochem Biophys Res Commun;
308(4): 698-705, 2003 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12927775
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