Common conditions of use elements. Atomic concepts for consistent and effective information governance.

Myriad policy, ethical and legal considerations underpin the sharing of biological resources, implying the need for standardised and yet flexible ways to digitally represent diverse 'use conditions'. We report a core lexicon of terms that are atomic, non-directional 'concepts of use', called Common Conditions of use Elements. This work engaged biobanks and registries relevant to the European Joint Programme for Rare Diseases and aimed to produce a lexicon that would have generalised utility. Seventy-six concepts were initially identified from diverse real-world settings, and via iterative rounds of deliberation and user-testing these were optimised and condensed down to 20 items. To validate utility, support software and training information was provided to biobanks and registries who were asked to create Sharing Policy Profiles. This succeeded and involved adding standardised directionality and scope annotations to the employed terms. The addition of free-text parameters was also explored. The approach is now being adopted by several real-world projects, enabling this standard to evolve progressively into a universal basis for representing and managing conditions of use.

Propofol-fentanyl en bolos por via endovenosa para mantenimiento anestésico en resonancia magnética de imágenes (MRI) / Intravenous bolous of propofol-fentanyl for anesthetic management in magnetic resonance imaging (MRI)

El presente estudio fue realizado con el objeto de evaluar la seguridad y eficacia de una Sedación o Anestesia en plano superficial con propofol en bolos por vía endovenosa. Se estudiaron 50 pacientes neurológicos, en donde la sedación se indujo con atropina a dosis de 0.01 mg/kg, fentanyl 1.0 µg/kg seguido de un bolo de propofol a 2.41 ñ 0.23 mg/kg promedio, para producir una adecuada inmovilización. El mantenimiento anestésico se realizó con bolos de propofol a 0.6 ñ 0.02 mg/kg en un tiempo promedio de 9.25 minutos por bolo. La calidad de la anestesia fue excelente en 43 y regular en 7 pacientes. Después de la inducción, la presión arterial media disminuyó transitoria pero significativamente, la frecuencia cardiaca, y la respiratoria no tuvieron modificaciones significativas. Consideramos la presente técnica como adecuada para la inducción y mantenimiento de la anestesia de pacientes que requieren estudios de Resonancia Magnética