The role of malignant tissue on the thermal distribution of cancerous breast.

The present work focuses on the integration of analytical and numerical strategies to investigate the thermal distribution of cancerous breasts. Coupled stationary bioheat transfer equations are considered for the glandular and heterogeneous tumor regions, which are characterized by different thermophysical properties. The cross-section of the cancerous breast is identified by a homogeneous glandular tissue that surrounds the heterogeneous tumor tissue, which is assumed to be a two-phase periodic composite with non-overlapping circular inclusions and a square lattice distribution, wherein the constituents exhibit isotropic thermal conductivity behavior. Asymptotic periodic homogenization method is used to find the effective properties in the heterogeneous region. The tissue effective thermal conductivities are computed analytically and then used in the homogenized model, which is solved numerically. Results are compared with appropriate experimental data reported in the literature. In particular, the tissue scale temperature profile agrees with experimental observations. Moreover, as a novelty result we find that the tumor volume fraction in the heterogeneous zone influences the breast surface temperature.

Effective Governing Equations for Viscoelastic Composites.

We derive the governing equations for the overall behaviour of linear viscoelastic composites comprising two families of elastic inclusions, subphases and/or fibres, and an incompressible Newtonian fluid interacting with the solid phases at the microscale. We assume that the distance between each of the subphases is very small in comparison to the length of the whole material (the macroscale). We can exploit this sharp scale separation and apply the asymptotic (periodic) homogenization method (AHM) which decouples spatial scales and leads to the derivation of the new homogenised model. It does this via upscaling the fluid-structure interaction problem that arises between the multiple elastic phases and the fluid. As we do not assume that the fluid flow is characterised by a parabolic profile, the new macroscale model, which consists of partial differential equations, is of Kelvin-Voigt viscoelastic type (rather than poroelastic). The novel model has coefficients that encode the properties of the microstructure and are to be computed by solving a single local differential fluid-structure interaction (FSI) problem where the solid and the fluid phases are all present and described by the one problem. The model reduces to the case described by Burridge and Keller (1981) when there is only one elastic phase in contact with the fluid. This model is applicable when the distance between adjacent phases is smaller than the average radius of the fluid flowing in the pores, which can be the case for various highly heterogeneous systems encountered in real-world (e.g., biological, or geological) scenarios of interest.

Effective Properties of Homogenised Nonlinear Viscoelastic Composites.

We develop a general approach for the computation of the effective properties of nonlinear viscoelastic composites. For this purpose, we employ the asymptotic homogenisation technique to decouple the equilibrium equation into a set of local problems. The theoretical framework is then specialised to the case of a strain energy density of the Saint-Venant type, with the second Piola-Kirchhoff stress tensor also featuring a memory contribution. Within this setting, we frame our mathematical model in the case of infinitesimal displacements and employ the correspondence principle which results from the use of the Laplace transform. In doing this, we obtain the classical cell problems in asymptotic homogenisation theory for linear viscoelastic composites and look for analytical solutions of the associated anti-plane cell problems for fibre-reinforced composites. Finally, we compute the effective coefficients by specifying different types of constitutive laws for the memory terms and compare our results with available data in the scientific literature.

Fluorescence recovery after photobleaching: direct measurement of diffusion anisotropy.

Fluorescence recovery after photobleaching (FRAP) is a widely used technique for studying diffusion in biological tissues. Most of the existing approaches for the analysis of FRAP experiments assume isotropic diffusion, while only a few account for anisotropic diffusion. In fibrous tissues, such as articular cartilage, tendons and ligaments, diffusion, the main mechanism for molecular transport, is anisotropic and depends on the fibre alignment. In this work, we solve the general diffusion equation governing a FRAP test, assuming an anisotropic diffusivity tensor and using a general initial condition for the case of an elliptical (thereby including the case of a circular) bleaching profile. We introduce a closed-form solution in the spatial coordinates, which can be applied directly to FRAP tests to extract the diffusivity tensor. We validate the approach by measuring the diffusivity tensor of [Formula: see text] FITC-Dextran in porcine medial collateral ligaments. The measured diffusion anisotropy was [Formula: see text] (SE), which is in agreement with that reported in the literature. The limitations of the approach, such as the size of the bleached region and the intensity of the bleaching, are studied using COMSOL simulations.