Detalles de la búsqueda
1.
CalTrack: High-Throughput Automated Calcium Transient Analysis in Cardiomyocytes.
Circ Res;
129(2): 326-341, 2021 07 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34018815
2.
Molecular Mechanisms of Deregulation of Muscle Contractility Caused by the R168H Mutation in TPM3 and Its Attenuation by Therapeutic Agents.
Int J Mol Sci;
24(6)2023 Mar 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36982903
3.
Genetics Matters: Voyaging from the Past into the Future of Humanity and Sustainability.
Int J Mol Sci;
23(7)2022 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-35409335
4.
Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Circulation;
141(10): 828-842, 2020 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31983222
5.
Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations.
Circ Res;
124(8): 1228-1239, 2019 04 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30732532
6.
Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7.
Int J Mol Sci;
22(12)2021 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34204776
7.
The molecular mechanism of muscle dysfunction associated with the R133W mutation in Tpm2.2.
Biochem Biophys Res Commun;
523(1): 258-262, 2020 02 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31864708
8.
Looking for Targets to Restore the Contractile Function in Congenital Myopathy Caused by Gln147Pro Tropomyosin.
Int J Mol Sci;
21(20)2020 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33066566
9.
Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation.
Int J Mol Sci;
21(12)2020 Jun 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32580284
10.
The molecular mechanisms of a high Ca2+-sensitivity and muscle weakness associated with the Ala155Thr substitution in Tpm3.12.
Biochem Biophys Res Commun;
515(2): 372-377, 2019 07 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31155291
11.
The reason for the low Ca2+-sensitivity of thin filaments associated with the Glu41Lys mutation in the TPM2 gene is "freezing" of tropomyosin near the outer domain of actin and inhibition of actin monomer switching off during the ATPase cycle.
Biochem Biophys Res Commun;
502(2): 209-214, 2018 07 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29792862
12.
The Primary Causes of Muscle Dysfunction Associated with the Point Mutations in Tpm3.12; Conformational Analysis of Mutant Proteins as a Tool for Classification of Myopathies.
Int J Mol Sci;
19(12)2018 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-30544720
13.
Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle.
Biochim Biophys Acta;
1864(3): 260-267, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26708479
14.
The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle.
Biochem Biophys Res Commun;
494(3-4): 681-686, 2017 12 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29097206
15.
Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca(2+)-sensitivity and suppress the modulation of Ca(2+)-sensitivity by troponin I phosphorylation.
Arch Biochem Biophys;
601: 113-20, 2016 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27036851
16.
Does extracellular cardiac troponin I play a pathogenic role independently of autoantibodies?
Clin Sci (Lond);
130(24): 2277-2278, 2016 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30897547
17.
Aberrant movement of ß-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin during the ATPase cycle.
Arch Biochem Biophys;
577-578: 11-23, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25978979
18.
The E117K mutation in ß-tropomyosin disturbs concerted conformational changes of actomyosin in muscle fibers.
Arch Biochem Biophys;
549: 12-6, 2014 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24657080
19.
Gly126Arg substitution causes anomalous behaviour of α-skeletal and ß-smooth tropomyosins during the ATPase cycle.
Arch Biochem Biophys;
543: 57-66, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24374033
20.
The effect of the Asp175Asn and Glu180Gly TPM1 mutations on actin-myosin interaction during the ATPase cycle.
Biochim Biophys Acta;
1824(2): 366-73, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-22155441