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1.

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.

Koivula, Robert W; Forgie, Ian M; Kurbasic, Azra; Viñuela, Ana; Heggie, Alison; Giordano, Giuseppe N; Hansen, Tue H; Hudson, Michelle; Koopman, Anitra D M; Rutters, Femke; Siloaho, Maritta; Allin, Kristine H; Brage, Søren; Brorsson, Caroline A; Dawed, Adem Y; De Masi, Federico; Groves, Christopher J; Kokkola, Tarja; Mahajan, Anubha; Perry, Mandy H; Rauh, Simone P; Ridderstråle, Martin; Teare, Harriet J A; Thomas, E Louise; Tura, Andrea; Vestergaard, Henrik; White, Tom; Adamski, Jerzy; Bell, Jimmy D; Beulens, Joline W; Brunak, Søren; Dermitzakis, Emmanouil T; Froguel, Philippe; Frost, Gary; Gupta, Ramneek; Hansen, Torben; Hattersley, Andrew; Jablonka, Bernd; Kaye, Jane; Laakso, Markku; McDonald, Timothy J; Pedersen, Oluf; Schwenk, Jochen M; Pavo, Imre; Mari, Andrea; McCarthy, Mark I; Ruetten, Hartmut; Walker, Mark; Pearson, Ewan; Franks, Paul W.

Diabetologia; 62(9): 1601-1615, 2019 09.

Artículo en Inglés | MEDLINE | ID: mdl-31203377

2.

Empagliflozin compared with glimepiride in metformin-treated patients with type 2 diabetes: 208-week data from a masked randomized controlled trial.

Ridderstråle, Martin; Rosenstock, Julio; Andersen, Knut R; Woerle, Hans J; Salsali, Afshin.

Diabetes Obes Metab; 20(12): 2768-2777, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-29961998

3.

Estimating the impact of changes in HbA1c, body weight and insulin injection regimen on health related quality-of-life: a time trade off study.

Ridderstråle, Martin; Evans, Lyndon Marc; Jensen, Henrik Holm; Bøgelund, Mette; Jensen, Marie Markert; Ericsson, Åsa; Jendle, Johan.

Health Qual Life Outcomes; 14: 13, 2016 Jan 22.

Artículo en Inglés | MEDLINE | ID: mdl-26801908

4.

Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: rationale and design of the epidemiological studies within the IMI DIRECT Consortium.

Koivula, Robert W; Heggie, Alison; Barnett, Anna; Cederberg, Henna; Hansen, Tue H; Koopman, Anitra D; Ridderstråle, Martin; Rutters, Femke; Vestergaard, Henrik; Gupta, Ramneek; Herrgård, Sanna; Heymans, Martijn W; Perry, Mandy H; Rauh, Simone; Siloaho, Maritta; Teare, Harriet J A; Thorand, Barbara; Bell, Jimmy; Brunak, Søren; Frost, Gary; Jablonka, Bernd; Mari, Andrea; McDonald, Tim J; Dekker, Jacqueline M; Hansen, Torben; Hattersley, Andrew; Laakso, Markku; Pedersen, Oluf; Koivisto, Veikko; Ruetten, Hartmut; Walker, Mark; Pearson, Ewan; Franks, Paul W.

Diabetologia; 57(6): 1132-42, 2014 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-24695864

5.

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 ß-cells accompany functional adaptations to lipotoxicity.

Malmgren, Siri; Spégel, Peter; Danielsson, Anders P H; Nagorny, Cecilia L; Andersson, Lotta E; Nitert, Marloes Dekker; Ridderstråle, Martin; Mulder, Hindrik; Ling, Charlotte.

J Biol Chem; 288(17): 11973-87, 2013 Apr 26.

Artículo en Inglés | MEDLINE | ID: mdl-23476019

6.

Personalized Intervention Based on Early Detection of Atherosclerosis: JACC State-of-the-Art Review.

Nielsen, Rikke V; Fuster, Valentin; Bundgaard, Henning; Fuster, Jose J; Johri, Amer M; Kofoed, Klaus F; Douglas, Pamela S; Diederichsen, Axel; Shapiro, Michael D; Nicholls, Stephen J; Nordestgaard, Børge G; Lindholt, Jes S; MacRae, Calum; Yuan, Chun; Newby, David E; Urbina, Elaine M; Bergström, Göran; Ridderstråle, Martin; Budoff, Matthew J; Bøttcher, Morten; Raitakari, Olli T; Hansen, Thomas H; Näslund, Ulf; Sillesen, Henrik; Eldrup, Nikolaj; Ibanez, Borja.

J Am Coll Cardiol; 83(21): 2112-2127, 2024 May 28.

Artículo en Inglés | MEDLINE | ID: mdl-38777513

7.

The association of cardiometabolic, diet and lifestyle parameters with plasma glucagon-like peptide-1: An IMI DIRECT study.

Eriksen, Rebeca; White, Margaret C; Dawed, Adem Y; Perez, Isabel Garcia; Posma, Joram M; Haid, Mark; Sharma, Sapna; Prehn, Cornelia; Thomas, Louise E; Koivula, Robert W; Bizzotto, Roberto; Mari, Andrea; Giordano, Giuseppe N; Pavo, Imre; Schwenk, Jochen M; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana; Mahajan, Anubha; McDonald, Timothy J; Kokkola, Tarja; Rutters, Femke; Beulens, Joline; Muilwijk, Mirthe; Blom, Marieke; Elders, Petra; Hansen, Tue H; Fernandez-Tajes, Juan; Jones, Angus; Jennison, Chris; Walker, Mark; McCarthy, Mark I; Pedersen, Oluf; Ruetten, Hartmut; Forgie, Ian; Holst, Jens J; Thomsen, Henrik S; Ridderstråle, Martin; Bell, Jimmy D; Adamski, Jerzy; Franks, Paul W; Hansen, Torben; Holmes, Elaine; Frost, Gary; Pearson, Ewan R.

J Clin Endocrinol Metab; 2024 Apr 30.

Artículo en Inglés | MEDLINE | ID: mdl-38686701

8.

Rationale, design and baseline characteristics of a 4-year (208-week) phase III trial of empagliflozin, an SGLT2 inhibitor, versus glimepiride as add-on to metformin in patients with type 2 diabetes mellitus with insufficient glycemic control.

Ridderstråle, Martin; Svaerd, Robbyna; Zeller, Cordula; Kim, Gabriel; Woerle, Hans J; Broedl, Uli C.

Cardiovasc Diabetol; 12: 129, 2013 Sep 05.

Artículo en Inglés | MEDLINE | ID: mdl-24007456

9.

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.

Mootha, Vamsi K; Lindgren, Cecilia M; Eriksson, Karl-Fredrik; Subramanian, Aravind; Sihag, Smita; Lehar, Joseph; Puigserver, Pere; Carlsson, Emma; Ridderstråle, Martin; Laurila, Esa; Houstis, Nicholas; Daly, Mark J; Patterson, Nick; Mesirov, Jill P; Golub, Todd R; Tamayo, Pablo; Spiegelman, Bruce; Lander, Eric S; Hirschhorn, Joel N; Altshuler, David; Groop, Leif C.

Nat Genet; 34(3): 267-73, 2003 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-12808457

10.

Precision medicine for cardiometabolic disease: a framework for clinical translation.

Franks, Paul W; Cefalu, William T; Dennis, John; Florez, Jose C; Mathieu, Chantal; Morton, Robert W; Ridderstråle, Martin; Sillesen, Henrik H; Stehouwer, Coen D A.

Lancet Diabetes Endocrinol; 11(11): 822-835, 2023 11.

Artículo en Inglés | MEDLINE | ID: mdl-37804856

11.

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits.

Brown, Andrew A; Fernandez-Tajes, Juan J; Hong, Mun-Gwan; Brorsson, Caroline A; Koivula, Robert W; Davtian, David; Dupuis, Théo; Sartori, Ambra; Michalettou, Theodora-Dafni; Forgie, Ian M; Adam, Jonathan; Allin, Kristine H; Caiazzo, Robert; Cederberg, Henna; De Masi, Federico; Elders, Petra J M; Giordano, Giuseppe N; Haid, Mark; Hansen, Torben; Hansen, Tue H; Hattersley, Andrew T; Heggie, Alison J; Howald, Cédric; Jones, Angus G; Kokkola, Tarja; Laakso, Markku; Mahajan, Anubha; Mari, Andrea; McDonald, Timothy J; McEvoy, Donna; Mourby, Miranda; Musholt, Petra B; Nilsson, Birgitte; Pattou, Francois; Penet, Deborah; Raverdy, Violeta; Ridderstråle, Martin; Romano, Luciana; Rutters, Femke; Sharma, Sapna; Teare, Harriet; 't Hart, Leen; Tsirigos, Konstantinos D; Vangipurapu, Jagadish; Vestergaard, Henrik; Brunak, Søren; Franks, Paul W; Frost, Gary; Grallert, Harald; Jablonka, Bernd.

Nat Commun; 14(1): 5062, 2023 08 21.

Artículo en Inglés | MEDLINE | ID: mdl-37604891

12.

Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study.

Wesolowska-Andersen, Agata; Brorsson, Caroline A; Bizzotto, Roberto; Mari, Andrea; Tura, Andrea; Koivula, Robert; Mahajan, Anubha; Vinuela, Ana; Tajes, Juan Fernandez; Sharma, Sapna; Haid, Mark; Prehn, Cornelia; Artati, Anna; Hong, Mun-Gwan; Musholt, Petra B; Kurbasic, Azra; De Masi, Federico; Tsirigos, Kostas; Pedersen, Helle Krogh; Gudmundsdottir, Valborg; Thomas, Cecilia Engel; Banasik, Karina; Jennison, Chrisopher; Jones, Angus; Kennedy, Gwen; Bell, Jimmy; Thomas, Louise; Frost, Gary; Thomsen, Henrik; Allin, Kristine; Hansen, Tue Haldor; Vestergaard, Henrik; Hansen, Torben; Rutters, Femke; Elders, Petra; t'Hart, Leen; Bonnefond, Amelie; Canouil, Mickaël; Brage, Soren; Kokkola, Tarja; Heggie, Alison; McEvoy, Donna; Hattersley, Andrew; McDonald, Timothy; Teare, Harriet; Ridderstrale, Martin; Walker, Mark; Forgie, Ian; Giordano, Giuseppe N; Froguel, Philippe.

Cell Rep Med; 3(1): 100477, 2022 01 18.

Artículo en Inglés | MEDLINE | ID: mdl-35106505

13.

Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity.

Deshmukh, Harshal A; Madsen, Anne Lundager; Viñuela, Ana; Have, Christian Theil; Grarup, Niels; Tura, Andrea; Mahajan, Anubha; Heggie, Alison J; Koivula, Robert W; De Masi, Federico; Tsirigos, Konstantinos K; Linneberg, Allan; Drivsholm, Thomas; Pedersen, Oluf; Sørensen, Thorkild I A; Astrup, Arne; Gjesing, Anette A P; Pavo, Imre; Wood, Andrew R; Ruetten, Hartmut; Jones, Angus G; Koopman, Anitra D M; Cederberg, Henna; Rutters, Femke; Ridderstrale, Martin; Laakso, Markku; McCarthy, Mark I; Frayling, Tim M; Ferrannini, Ele; Franks, Paul W; Pearson, Ewan R; Mari, Andrea; Hansen, Torben; Walker, Mark.

J Clin Endocrinol Metab; 106(1): 80-90, 2021 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-32944759

14.

Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study.

Bizzotto, Roberto; Jennison, Christopher; Jones, Angus G; Kurbasic, Azra; Tura, Andrea; Kennedy, Gwen; Bell, Jimmy D; Thomas, E Louise; Frost, Gary; Eriksen, Rebeca; Koivula, Robert W; Brage, Soren; Kaye, Jane; Hattersley, Andrew T; Heggie, Alison; McEvoy, Donna; 't Hart, Leen M; Beulens, Joline W; Elders, Petra; Musholt, Petra B; Ridderstråle, Martin; Hansen, Tue H; Allin, Kristine H; Hansen, Torben; Vestergaard, Henrik; Lundgaard, Agnete T; Thomsen, Henrik S; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana; Mahajan, Anubha; McDonald, Timothy J; Kokkola, Tarja; Forgie, Ian M; Giordano, Giuseppe N; Pavo, Imre; Ruetten, Hartmut; Dermitzakis, Emmanouil; McCarthy, Mark I; Pedersen, Oluf; Schwenk, Jochen M; Adamski, Jerzy; Franks, Paul W; Walker, Mark; Pearson, Ewan R; Mari, Andrea.

Diabetes Care; 44(2): 511-518, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33323478

15.

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study.

Tura, Andrea; Grespan, Eleonora; Göbl, Christian S; Koivula, Robert W; Franks, Paul W; Pearson, Ewan R; Walker, Mark; Forgie, Ian M; Giordano, Giuseppe N; Pavo, Imre; Ruetten, Hartmut; Dermitzakis, Emmanouil T; McCarthy, Mark I; Pedersen, Oluf; Schwenk, Jochen M; Adamski, Jerzy; De Masi, Federico; Tsirigos, Konstantinos D; Brunak, Søren; Viñuela, Ana; Mahajan, Anubha; McDonald, Timothy J; Kokkola, Tarja; Vangipurapu, Jagadish; Cederberg, Henna; Laakso, Markku; Rutters, Femke; Elders, Petra J M; Koopman, Anitra D M; Beulens, Joline W; Ridderstråle, Martin; Hansen, Tue H; Allin, Kristine H; Hansen, Torben; Vestergaard, Henrik; Mari, Andrea.

Diabetes; 70(9): 2092-2106, 2021 09.

Artículo en Inglés | MEDLINE | ID: mdl-34233929

16.

Prediction of non-alcoholic fatty liver disease and liver fat using metabolic and genetic factors.

Kotronen, Anna; Peltonen, Markku; Hakkarainen, Antti; Sevastianova, Ksenia; Bergholm, Robert; Johansson, Lina M; Lundbom, Nina; Rissanen, Aila; Ridderstråle, Martin; Groop, Leif; Orho-Melander, Marju; Yki-Järvinen, Hannele.

Gastroenterology; 137(3): 865-72, 2009 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-19524579

17.

Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study.

Gudmundsdottir, Valborg; Pedersen, Helle Krogh; Mazzoni, Gianluca; Allin, Kristine H; Artati, Anna; Beulens, Joline W; Banasik, Karina; Brorsson, Caroline; Cederberg, Henna; Chabanova, Elizaveta; De Masi, Federico; Elders, Petra J; Forgie, Ian; Giordano, Giuseppe N; Grallert, Harald; Gupta, Ramneek; Haid, Mark; Hansen, Torben; Hansen, Tue H; Hattersley, Andrew T; Heggie, Alison; Hong, Mun-Gwan; Jones, Angus G; Koivula, Robert; Kokkola, Tarja; Laakso, Markku; Løngreen, Peter; Mahajan, Anubha; Mari, Andrea; McDonald, Timothy J; McEvoy, Donna; Musholt, Petra B; Pavo, Imre; Prehn, Cornelia; Ruetten, Hartmut; Ridderstråle, Martin; Rutters, Femke; Sharma, Sapna; Slieker, Roderick C; Syed, Ali; Tajes, Juan Fernandez; Thomas, Cecilia Engel; Thomsen, Henrik S; Vangipurapu, Jagadish; Vestergaard, Henrik; Viñuela, Ana; Wesolowska-Andersen, Agata; Walker, Mark; Adamski, Jerzy; Schwenk, Jochen M.

Genome Med; 12(1): 109, 2020 12 01.

Artículo en Inglés | MEDLINE | ID: mdl-33261667

18.

Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study.

Obura, Morgan; Beulens, Joline W J; Slieker, Roderick; Koopman, Anitra D M; Hoekstra, Trynke; Nijpels, Giel; Elders, Petra; Koivula, Robert W; Kurbasic, Azra; Laakso, Markku; Hansen, Tue H; Ridderstråle, Martin; Hansen, Torben; Pavo, Imre; Forgie, Ian; Jablonka, Bernd; Ruetten, Hartmut; Mari, Andrea; McCarthy, Mark I; Walker, Mark; Heggie, Alison; McDonald, Timothy J; Perry, Mandy H; De Masi, Federico; Brunak, Søren; Mahajan, Anubha; Giordano, Giuseppe N; Kokkola, Tarja; Dermitzakis, Emmanouil; Viñuela, Ana; Pedersen, Oluf; Schwenk, Jochen M; Adamski, Jurek; Teare, Harriet J A; Pearson, Ewan R; Franks, Paul W; 't Hart, Leen M; Rutters, Femke.

PLoS One; 15(11): e0242360, 2020.

Artículo en Inglés | MEDLINE | ID: mdl-33253307

19.

Genetic dissection of type 2 diabetes.

Ridderstråle, Martin; Groop, Leif.

Mol Cell Endocrinol; 297(1-2): 10-7, 2009 Jan 15.

Artículo en Inglés | MEDLINE | ID: mdl-19000735

20.

Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain.

Geidenstam, Nina; Hsu, Yu-Han H; Astley, Christina M; Mercader, Josep M; Ridderstråle, Martin; Gonzalez, Maria E; Gonzalez, Clicerio; Hirschhorn, Joel N; Salem, Rany M.

PLoS One; 14(9): e0222445, 2019.

Artículo en Inglés | MEDLINE | ID: mdl-31560688

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