RESUMEN
BACKGROUND: Prolonged psychological stress is a risk factor for illness and constitutes an increasing public health challenge creating a need to develop public interventions specifically targeting stress and promoting mental health. The present randomized controlled trial evaluated health effects of a novel program: Relaxation-Response-based Mental Health Promotion (RR-MHP). METHODS: The multimodal, meditation-based course was publicly entitled "Open and Calm" (OC) because it consistently trained relaxed and receptive ("Open") attention, and consciously non-intervening ("Calm") witnessing, in two standardized formats (individual or group) over nine weeks. Seventy-two participants who complained to their general practitioner about reduced daily functioning due to prolonged stress or who responded to an online health survey on stress were randomly assigned to OC formats or treatment as usual, involving e.g., unstandardized consultations with their general practitioner. Outcomes included perceived stress, depressive symptoms, quality of life, sleep disturbances, mental health, salivary cortisol, and visual perception. Control variables comprised a genetic stress-resiliency factor (serotonergic transporter genotype; 5-HTTLPR), demographics, personality, self-reported inattentiveness, and course format. RESULTS: Intent-to-treat analyses showed significantly larger improvements in OC than in controls on all outcomes. Treatment effects on self-reported outcomes were sustained after 3 months and were not related to age, gender, education, or course format. The dropout rate was only 6 %. CONCLUSIONS: The standardized OC program reduced stress and improved mental health for a period of 3 months. Further testing of the OC program for public mental health promotion and reduction of stress-related illnesses is therefore warranted. A larger implementation is in progress. TRIAL REGISTRATION: ClinicalTrials.gov.: NCT02140307. Registered May 14 2014.
Asunto(s)
Promoción de la Salud/métodos , Meditación/métodos , Evaluación de Programas y Proyectos de Salud , Relajación , Estrés Psicológico/terapia , Adulto , Atención , Dinamarca , Depresión/psicología , Femenino , Humanos , Hidrocortisona/análisis , Masculino , Salud Mental , Persona de Mediana Edad , Calidad de Vida , Saliva/química , Trastornos del Sueño-Vigilia/psicología , Estrés Psicológico/psicologíaRESUMEN
Chronic traumatic encephalopathy (CTE) is associated with a history of repetitive head impacts, such as those sustained through contact sports. Post-mortem assessment has revealed specific neuropathological characteristics related to the condition. The symptoms of CTE typically present several years after exposure and can include mood/behavioural changes, cognitive dysfunction and motor symptoms. The course of CTE can potentially be progressive and debilitating. In this review, we argue, that there is a need for validated neuropathological and clinical criteria in order to detect CTE ante-mortem in the population.