Detalles de la búsqueda
1.
Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
Bioorg Med Chem;
63: 116729, 2022 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35439688
2.
Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors.
Bioorg Med Chem;
28(23): 115815, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33091850
3.
Potent and selective bivalent inhibitors of BET bromodomains.
Nat Chem Biol;
12(12): 1097-1104, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27775716
4.
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.
Bioorg Med Chem;
26(4): 913-924, 2018 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29398441
5.
Discovery of potent, selective small molecule inhibitors of α-subtype of type III phosphatidylinositol-4-kinase (PI4KIIIα).
Bioorg Med Chem Lett;
25(16): 3189-93, 2015 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26087940
6.
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
J Med Chem;
67(4): 3090-3111, 2024 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38306388
7.
Development of a Series of Pyrrolopyridone MAT2A Inhibitors.
J Med Chem;
67(6): 4541-4559, 2024 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38466661
8.
Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.
J Med Chem;
67(2): 1500-1512, 2024 Jan 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38227216
9.
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRASG12C with Demonstrable CNS Penetration.
J Med Chem;
66(13): 9147-9160, 2023 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37395055
10.
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold.
Bioorg Med Chem Lett;
22(24): 7302-5, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23149230
11.
Discovery of a Series of 5-Azaquinazolines as Orally Efficacious IRAK4 Inhibitors Targeting MyD88L265P Mutant Diffuse Large B Cell Lymphoma.
J Med Chem;
62(21): 9918-9930, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31622099
12.
Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles.
J Med Chem;
62(21): 9418-9437, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31361481
13.
Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
ACS Chem Biol;
13(11): 3131-3141, 2018 11 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30335946
14.
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.
J Med Chem;
60(24): 10071-10091, 2017 12 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-29172502
15.
Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
J Med Chem;
60(10): 4386-4402, 2017 05 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-28485934
16.
Correction to "Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles".
J Med Chem;
64(5): 2849, 2021 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33646774
17.
Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology.
ACS Med Chem Lett;
6(3): 254-9, 2015 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25815142
18.
Optimization of brain penetrant 11ß-hydroxysteroid dehydrogenase type I inhibitors and in vivo testing in diet-induced obese mice.
J Med Chem;
57(3): 970-86, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24422550
19.
Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not ß-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation.
Chem Commun (Camb);
50(40): 5388-90, 2014 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-24366037
20.
Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists.
J Med Chem;
57(14): 6128-40, 2014 Jul 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-24967667