Marine Seagrass Extract of Thalassia testudinum Suppresses Colorectal Tumor Growth, Motility and Angiogenesis by Autophagic Stress and Immunogenic Cell Death Pathways.

Marine plants have become an inexhaustible reservoir of new phytopharmaceuticals for cancer treatment. We demonstrate in vitro/in vivo antitumor efficacy of a standardized polyphenol extract from the marine angiosperm Thalassia testudinum (TTE) in colon tumor cell lines (RKO, SW480, and CT26) and a syngeneic allograft murine colorectal cancer model. MTT assays revealed a dose-dependent decrease of cell viability of RKO, CT26, and SW480 cells upon TTE treatment with IC50 values of, respectively, 175, 115, and 60 µg/mL. Furthermore, TTE significantly prevented basal and bFGF-induced angiogenesis in the chicken chorioallantoic membrane angiogenesis assay. In addition, TTE suppressed bFGF-induced migration of endothelial cells in a wound closure assay. Finally, TTE treatment abrogated CT26 colorectal cancer growth and increased overall organism survival in a syngeneic murine allograft model. Corresponding transcriptome profiling and pathway analysis allowed for the identification of the mechanism of action for the antitumor effects of TTE. In line with our in vitro/in vivo results, TTE treatment triggers ATF4-P53-NFκB specific gene expression and autophagy stress pathways. This results in suppression of colon cancer cell growth, cell motility, and angiogenesis pathways in vitro and in addition promotes antitumor immunogenic cell death in vivo.

Supporting Self-Management of Cardiovascular Diseases Through Remote Monitoring Technologies: Metaethnography Review of Frameworks, Models, and Theories Used in Research and Development.

BACKGROUND: Electronic health (eHealth) is a rapidly evolving field informed by multiple scientific disciplines. Because of this, the use of different terms and concepts to explain the same phenomena and lack of standardization in reporting interventions often leaves a gap that hinders knowledge accumulation. Interventions focused on self-management support of cardiovascular diseases through the use of remote monitoring technologies are a cross-disciplinary area potentially affected by this gap. A review of the underlying frameworks, models, and theories that have informed projects at this crossroad could advance future research and development efforts. OBJECTIVE: This research aimed to identify and compare underlying approaches that have informed interventions focused on self-management support of cardiovascular diseases through the use of remote monitoring technologies. The objective was to achieve an understanding of the distinct approaches by highlighting common or conflicting principles, guidelines, and methods. METHODS: The metaethnography approach was used to review and synthesize researchers' reports on how they applied frameworks, models, and theories in their projects. Literature was systematically searched in 7 databases: Scopus, Web of Science, EMBASE, CINAHL, PsycINFO, Association for Computing Machinery Digital Library, and Cochrane Library. Included studies were thoroughly read and coded to extract data for the synthesis. Studies were mainly related by the key ingredients of the underlying approaches they applied. The key ingredients were finally translated across studies and synthesized into thematic clusters. RESULTS: Of 1224 initial results, 17 articles were included. The articles described research and development of 10 different projects. Frameworks, models, and theories (n=43) applied by the projects were identified. Key ingredients (n=293) of the included articles were mapped to the following themes of eHealth development: (1) it is a participatory process; (2) it creates new infrastructures for improving health care, health, and well-being; (3) it is intertwined with implementation; (4) it integrates theory, evidence, and participatory approaches for persuasive design; (5) it requires continuous evaluation cycles; (6) it targets behavior change; (7) it targets technology adoption; and (8) it targets health-related outcomes. CONCLUSIONS: The findings of this review support and exemplify the numerous possibilities in the use of frameworks, models, and theories to guide research and development of eHealth. Participatory, user-centered design, and integration with empirical evidence and theoretical modeling were widely identified principles in the literature. On the contrary, less attention has been given to the integration of implementation in the development process and supporting novel eHealth-based health care infrastructures. To better integrate theory and evidence, holistic approaches can combine patient-centered studies with consolidated knowledge from expert-based approaches. TRIAL REGISTRATION: PROSPERO CRD42018104397; https://tinyurl.com/y8ajyajt. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR2-10.2196/13334.

Incremental 3D Cuboid Modeling with Drift Compensation.

This paper presents a framework of incremental 3D cuboid modeling by using the mapping results of an RGB-D camera based simultaneous localization and mapping (SLAM) system. This framework is useful in accurately creating cuboid CAD models from a point cloud in an online manner. While performing the RGB-D SLAM, planes are incrementally reconstructed from a point cloud in each frame to create a plane map. Then, cuboids are detected in the plane map by analyzing the positional relationships between the planes, such as orthogonality, convexity, and proximity. Finally, the position, pose, and size of a cuboid are determined by computing the intersection of three perpendicular planes. To suppress the false detection of the cuboids, the cuboid shapes are incrementally updated with sequential measurements to check the uncertainty of the cuboids. In addition, the drift error of the SLAM is compensated by the registration of the cuboids. As an application of our framework, an augmented reality-based interactive cuboid modeling system was developed. In the evaluation at cluttered environments, the precision and recall of the cuboid detection were investigated, compared with a batch-based cuboid detection method, so that the advantages of our proposed method were clarified.

COMPADRE: an R and web resource for pathway activity analysis by component decompositions.

UNLABELLED: The analysis of biological networks has become essential to study functional genomic data. Compadre is a tool to estimate pathway/gene sets activity indexes using sub-matrix decompositions for biological networks analyses. The Compadre pipeline also includes one of the direct uses of activity indexes to detect altered gene sets. For this, the gene expression sub-matrix of a gene set is decomposed into components, which are used to test differences between groups of samples. This procedure is performed with and without differentially expressed genes to decrease false calls. During this process, Compadre also performs an over-representation test. Compadre already implements four decomposition methods [principal component analysis (PCA), Isomaps, independent component analysis (ICA) and non-negative matrix factorization (NMF)], six statistical tests (t- and f-test, SAM, Kruskal-Wallis, Welch and Brown-Forsythe), several gene sets (KEGG, BioCarta, Reactome, GO and MsigDB) and can be easily expanded. Our simulation results shown in Supplementary Information suggest that Compadre detects more pathways than over-representation tools like David, Babelomics and Webgestalt and less false positives than PLAGE. The output is composed of results from decomposition and over-representation analyses providing a more complete biological picture. Examples provided in Supplementary Information show the utility, versatility and simplicity of Compadre for analyses of biological networks. AVAILABILITY AND IMPLEMENTATION: Compadre is freely available at http://bioinformatica.mty.itesm.mx:8080/compadre. The R package is also available at https://sourceforge.net/p/compadre.

Measurement scales of mental health related to climate change: a scoping review protocol using artificial intelligence.

INTRODUCTION: Human actions have influenced climate changes around the globe, causing extreme weather phenomena and impacting communities worldwide. Climate change has caused, directly or indirectly, health effects such as injury and physical injuries, which impact morbidity and mortality. Similarly, there is evidence that exposure to climatic catastrophes has serious repercussions on psychological well-being, and rising temperatures and drought have detrimental effects on mental health.Despite the recent effort of researchers to develop specific instruments to assess the effects of climate change on mental health, the evidence on measures of its impact is still scarce, and the constructs are heterogeneous. The aim of this scoping review is to describe the instruments developed and validated to assess the impact of mental health related to climate change. METHODS AND ANALYSIS: This review is registered at Open Science Framework (https://osf.io/zdmbk). This scoping review will follow the reporting elements chosen for systematic review and meta-analysis (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). We proposed a PO question, as it places no restrictions on the participants (P), and the outcome (O) are measurement instruments on mental health related to climate change. A search will be conducted in different databases (PubMed, Scopus, Web of Science, PsycINFO). We will use an open-source artificial intelligence screening tool (ASReview LAB) for the title and abstract review. The full-text review will be performed by three researchers. If there is a disagreement between two independent reviewers, a third reviewer will take the final decision. We will use the COnsensus-based Standards for the selection of health Measurement INstruments tool to assess the risk of bias for each included study. The review will be conducted starting in September 2023. ETHICS AND DISSEMINATION: The planned scoping review does not require ethical approval since it will not involve an ethical risk to the participants. The results obtained from this study will be presented at conferences, congresses and scientific publications.

Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spread.

PURPOSE: Bladder plasmacytoid carcinoma is an invasive urothelial carcinoma subtype that is emphasized for its morphological overlap with plasma cells and metastatic carcinoma. Our experience suggests frequent intraperitoneal spread that is not typical of conventional urothelial carcinoma. MATERIALS AND METHODS: We identified cases of plasmacytoid urothelial carcinoma diagnosed on radical cystectomy. Patient age, gender, American Joint Committee on Cancer (7th edition) stage, metastatic spread/recurrence sites and clinical disease status at last followup were recorded. RESULTS: A total of 10 male and 5 female patients 42 to 81 years old were identified. One tumor was pT2, 11 pT3 and 3 pT4. Six of 15 patients (40%) presented with lymph node metastasis and 5 (33%) had intraperitoneal metastasis at cystectomy. These initial sites of metastatic spread included the prerectal space, ovary and vagina, ovary and fallopian tube, bowel serosa, and omentum and bowel serosa in 1 case each. Three patients had subsequent metastasis involving the prerectal space, pleural fluid and small bowel serosa, and bowel serosa in 1 each. Eight patients had followup information available, including 3 who died of disease, 3 with disease and 2 with no evidence of disease. CONCLUSIONS: Of the patients 33% with the plasmacytoid variant of urothelial carcinoma presented with intraperitoneal disease spread and 20% had subsequent metastasis involving serosal surfaces. The possibility of noncontiguous intraperitoneal spread involving serosal surfaces should be recognized to ensure proper intraoperative staging and clinical followup for patients with plasmacytoid carcinoma.

[Transnasal endoscopic skull base surgery: analysis of complications in the first 120 procedures]. / Cirugía endoscópica transnasal de base de cráneo: Análisis de las complicaciones en los primeros 120 procedimientos.

Background: The endonasal endoscopic approach (EEA) has potential advantages over traditional open approaches. However, complications such as cerebrospinal fluid (CFS) leak, visual disturbances, and postoperative meningitis have been described. The aim was to present the experience accumulated in 120 cases of skull base EEA performed by the same surgical team and describe and analyze the main postoperative complications according to the complexity of the cases. Methods: Retrospective study on our database of patients undergoing skull base EEA for various pathologies between July 2011 and March 2022. Results: 120 skull base EEA surgeries were analyzed. 57.14% were performed on women. The median age was 44 years. 26.66% were reinterventions. The most frequent pathology was pituitary adenoma (49.17%) followed by CSF leak (8.33%). The most used EEA was the transelar 65.83%. 26 complications were recorded, with no differences according to complexity. There were 13 cases of diabetes insipidus (DI) and 8 of CSF leak. This was more frequent in patients with intraoperative CSF leak. The median hospital stay was 5.5 days. Conclusion: Skull base EEA has become increasingly common for the surgical management of skull base pathology, with a low frequency of immediate postoperative complications and low mortality. The improvement of the technique and the improvement in postoperative care are associated with a shorter hospital stay.

Determining relevant traits for selecting landrace accessions of Phaseolus lunatus L. for insect resistance.

Plant-insect interactions are a determining factor for sustainable crop production. Although plants can resist or tolerate herbivorous insects to varying degrees, even with the use of pesticides, insects can reduce plant net productivity by as much as 20%, so sustainable strategies for pest control with less dependence on chemicals are needed. Selecting plants with optimal resistance and photosynthetic traits can help minimize damage and maintain productivity. Here, 27 landrace accessions of lima beans, Phaseolus lunatus L., from the Yucatan Peninsula were evaluated in the field for morphological resistance traits, photosynthetic characteristics, insect damage and seed yield. Variation was found in physical leaf traits (number, area, and dry mass of leaves; trichome density, specific leaf thickness and hardness) and in physiological traits (photosynthetic rate, stomatal conductance, intercellular carbon, water-use efficiency, and transpiration). Five accessions (JMC1325, JMC1288, JMC1339, JMC1208 and JMC1264) had the lowest index for cumulative damage with the highest seed yield, although RDA analysis uncovered two accessions (JMC1339, JMC1288) with strong positive association of seed yield and the cumulative damage index with leaf production, specific leaf area (SLA) and total leaf area. Leaf traits, including SLA and total leaf area are important drivers for optimizing seed yield. This study identified 12 important morphological and physiological leaf traits for selecting landrace accessions of P. lunatus for high yields (regardless of damage level) to achieve sustainable, environmentally safe crop production.

Toward the Value Sensitive Design of eHealth Technologies to Support Self-management of Cardiovascular Diseases: Content Analysis.

BACKGROUND: eHealth can revolutionize the way self-management support is offered to chronically ill individuals such as those with a cardiovascular disease (CVD). However, patients' fluctuating motivation to actually perform self-management is an important factor for which to account. Tailoring and personalizing eHealth to fit with the values of individuals promises to be an effective motivational strategy. Nevertheless, how specific eHealth technologies and design features could potentially contribute to values of individuals with a CVD has not been explicitly studied before. OBJECTIVE: This study sought to connect a set of empirically validated, health-related values of individuals with a CVD with existing eHealth technologies and their design features. The study searched for potential connections between design features and values with the goal to advance knowledge about how eHealth technologies can actually be more meaningful and motivating for end users. METHODS: Undertaking a technical investigation that fits with the value sensitive design framework, a content analysis of existing eHealth technologies was conducted. We matched 11 empirically validated values of CVD patients with 70 design features from 10 eHealth technologies that were previously identified in a systematic review. The analysis consisted mainly of a deductive coding stage performed independently by 3 members of the study team. In addition, researchers and developers of 6 of the 10 reviewed technologies provided input about potential feature-value connections. RESULTS: In total, 98 connections were made between eHealth design features and patient values. This meant that some design features could contribute to multiple values. Importantly, some values were more often addressed than others. CVD patients' values most often addressed were related to (1) having or maintaining a healthy lifestyle, (2) having an overview of personal health data, (3) having reliable information and advice, (4) having extrinsic motivators to accomplish goals or health-related activities, and (5) receiving personalized care. In contrast, values less often addressed concerned (6) perceiving low thresholds to access health care, (7) receiving social support, (8) preserving a sense of autonomy over life, and (9) not feeling fear, anxiety, or insecurity about health. Last, 2 largely unaddressed values were related to (10) having confidence and self-efficacy in the treatment or ability to achieve goals and (11) desiring to be seen as a person rather than a patient. CONCLUSIONS: Positively, existing eHealth technologies could be connected with CVD patients' values, largely through design features that relate to educational support, self-monitoring support, behavior change support, feedback, and motivational incentives. Other design features such as reminders, prompts or cues, peer-based or expert-based human support, and general system personalization were also connected with values but in narrower ways. In future studies, the inferred feature-value connections must be validated with empirical data from individuals with a CVD or similar chronic conditions.

Frameworks, Models, and Theories Used in Electronic Health Research and Development to Support Self-Management of Cardiovascular Diseases Through Remote Monitoring Technologies: Protocol for a Metaethnography Review.

BACKGROUND: Electronic health (eHealth) is a multidisciplinary and rapidly evolving field, and thus requires research focused on knowledge accumulation, curation, and translation. Cardiovascular diseases constitute a global health care crisis in which eHealth can provide novel solutions to improve the efficiency and reach of self-management support for patients where they most need it: their homes and communities. A holistic understanding of eHealth projects focused on such case is required to bridge the multidisciplinary gap formed by the wide range of aims and approaches taken by the various disciplines involved. OBJECTIVE: The primary objective of this review is to facilitate a holistic interpretation of eHealth projects aimed at providing self-management support of cardiovascular diseases in the natural setting of patients, thus priming the use of remote monitoring technologies. The review aims to synthesize the operationalization of frameworks, models, and theories applied to the research and development process of eHealth. METHODS: We will use Noblit and Hare's metaethnography approach to review and synthesize researchers' and practitioners' reports on how they applied frameworks, models, and theories in their projects. We will systematically search the literature in 7 databases: Scopus, Web of Science, EMBASE, CINAHL, PsycINFO, ACM Digital Library, and the Cochrane Library. We will thoroughly read and code selected studies to extract both raw and contextual data for the synthesis. The relation of the studies will be determined according to the elements of the frameworks, models, or theories the studies applied. We will translate these elements between each other and intend to synthesize holistic principles for eHealth development for the case at hand. RESULTS: The search strategy has been completed, data extraction is almost finalized, and the first synthesis approaches are underway. The search yielded 1224 citations and, after we applied the selection criteria, 17 articles remained. We expect to submit the final results for publication in 2019. CONCLUSIONS: This review is important because it aims to create a holistic understanding of a multidisciplinary topic at the crossroads of eHealth, cardiovascular diseases, and self-management. The value of metaethnography in contrast to other systematic review methods is that its synthesis approach seeks to generate a new understanding of a topic, while preserving the social and theoretical contexts in which findings emerge. Our results will show how useful this method can be in bridging the multidisciplinary gap of eHealth research and development, to inform and advance the importance of holistic approaches, while showcasing this approach for the case of self-management in cardiovascular diseases. TRIAL REGISTRATION: PROSPERO CRD42018104397; https://www.crd.york.ac.uk/PROSPERO/display_record.php? RecordID=104397 (Archived by WebCite at http://www.webcitation.org/75H1kP1Mm). INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/13334.

Métodos para la detección de cardiopatías congénitas en neonatos

Las cardiopatías congénitas conforman el grupo de las malformaciones innatas más comunes, siendo vital su detección temprana. Este estudio tuvo por objetivo caracterizar las publicaciones acerca de los métodos para la detección de cardiopatías congénitas en neonatos a partir de tres categorías: las características generales de las investigaciones, la información de los investigadores y la definición y características de las metodologías practicadas. Para tal efecto, y con ayuda de tablas dinámicas de MS Excel 16.52 y el software VOSviewer 1.6.17, se llevó a cabo una revisión sistematizada que permitió recopilar 63 artículos publicados entre 2010 y 2021 en Scopus, Web of Science y PubMed. Los hallazgos evidencian que la producción académica ha ido incrementándose desde el 2018, teniendo a Estados Unidos a la vanguardia de esta y siendo la ecocardiografía y la oximetría los procedimientos más estudiados. La comparación entre las metodologías advierte que la detección por oximetría es la más destacable, en cuanto a los factores evaluados. Esta investigación abre nuevas líneas de indagación en la materia con la finalidad de desarrollar y aplicar nuevas metodologías o perfeccionar las ya existentes para que se ajusten a las necesidades de la población.

Congenital heart disease is one of the most common innate malformations, and early detection is vital. The aim of this study was to characterize the publications on methods for the detection of congenital heart disease in neonates based on three categories: the general characteristics of the investigations, the information provided by the researchers, and the definition and characteristics of the methodologies used. For this purpose, and with the help of MS Excel 16.52 pivot tables and VOSviewer 1.6.17 software, a systematized review was carried out that allowed us to compile 63 articles published between 2010 and 2021 in Scopus, Web of Science and PubMed. The findings evidence that academic production has been increasing since 2018, with the United States being at the forefront of this and echocardiography and oximetry being the most studied procedures. The comparison between the methodologies warns that detection by oximetry is the most outstanding in terms of the factors evaluated. This research opens up new lines of investigation in the field with the aim of developing and applying new methodologies or improving existing ones to meet the needs of the population.

Caracterización clínica y tratamiento de pacientes ingresados por la COVID-19 en terapias intensivascubanas

RESUMEN Introducción: La pandemia por la COVID-19 fue declarada emergencia de salud pública internacional. El conocimiento de los síntomas, comorbilidades y el riesgo según el tratamiento recibido puede contribuir a una mejor clasificación y atención de los pacientes. Objetivo: Caracterizar clínicamente a los pacientes de COVID-19 atendidos en las unidades de terapia intensiva cubanas. Métodos: Estudio observacional retrospectivo de todos los pacientes atendidos en las unidades de terapia intensiva de Cuba en el periodo comprendido entre el 11 de marzo y el 30 de julio de 2020. Se recolectaron datos demográficos, clínicos y de resultados. Se compararon los pacientes fallecidos y recuperados de acuerdo a la prevalencia de las covariables a través de una prueba estándar de chi-cuadrado. Se realizó regresión logística para evaluar las variables predictoras de la mortalidad hospitalaria. Resultados: Se atendieron 175 pacientes, de ellos 106 graves y 69 críticos. Predominó el sexo masculino (52,0 %), mayores de 60 años (67,2 %) con hipertensión arterial (57,0 %). La edad (mayores de 80 años, OR= 9,62, IC95%: 3,16-29,2), el estado al ingreso (OR= 8,32, IC95%: 2.30-30,10) y la inestabilidad hemodinámica (OR=6,9, IC95%:2,96-16,37), se asociaron a un mayor riesgo de fallecimiento. Los pacientes tratados con kaletra, cloroquina, itolizumab o jusvinza incrementaron la supervivencia. El riesgo de fallecimiento en los críticos disminuyó de 80 a 25% con el uso de jusvinza. Conclusiones: La caracterización clínica realizada demuestra la efectividad de los protocolos clínicos empleados en las unidades de terapia intensiva del país.

ABSTRACT Introduction: COVID-19 pandemic was declared an international public health emergency. The knowledge of the symptoms, comorbidities, and the risk associated with the treatment received could contribute to better classification and care of patients. Objective: To clinically characterize COVID-19 patients admitted to the Cuban intensive care units Methods: A retrospective observational study of all patients treated in the Cuban intensive care units from March 11 to July 30, 2020. Demographic, clinical and outcome data were collected. The prevalence of fatal and recovery cases was compared by covariables using the standard chi-square test. A logistic regression was performed to evaluate the predictor variables for in-hospital mortality. Results: A total of 175 patients were treated, including 106 acutely ill and 69 critically ill. Patients were predominantly male (52.0%), over 60 years old (67.2%) and had hypertension (57.0%). Age (over 80 years old, OR= 9.62, 95% CI: 3.16-29.2), health status at admission (OR= 8.32, 95% CI: 2.30-30.10), and hemodynamic instability (OR=6.9, 95% CI: 2.96-16.37) were associated with an increased risk of death. Patients treated with Kaletra, chloroquine, Itolizumab, or Jusvinza increased survival. Mortality risk in critically ill patients decreased from 80% to 25% with the use of Jusvinza. Conclusions: The clinical characterization performed demonstrates the effectiveness of the clinical protocols used in the country's intensive care units.

Trabalho, educação e juventudes: diálogo com o pensamento social de christian laval e pierre dardot / Work, education and youths: a dialogue with the social thinking of christian laval and pierre dardot / Trabajo, educación y juventudes: diálogo con el pensamiento social de christian laval y pierre dardo

Resumo O presente estudo teórico propõe um dia-gnóstico crítico das relações entre trabalho, educação e juventudes contemporâneas, por meio de um breve diálogo com o pensamento social de Christian Laval e Pierre Dardot. Sua preocupação central encontra-se na emergência de novos arranjos subjetivos no contexto do neoliberalismo. Para pensar tais relações foram considerados três traços conceituais derivados das obras dos autores selecionados: a compreensão da crise como modo de vida permanente, a ênfase nos aspectos emocionais e no dispositivo desempenho/gozo e a reinscrição da formação juvenil no território do comum. Ao longo do estudo, evidencia-se que um referencial analítico crítico e heterodoxo, sustentado numa releitura específica do pensamento de Marx articulada a outras contribuições, da forma como tratado por Dardot e Laval, apresenta potencialidade heurística significativa para pensar os conceitos de trabalho, educação e juventude no contexto brasileiro atual.

Abstract The present theoretical study proposes a critical diagnosis of the relationships among work, education, and contemporary youths through a brief dialogue with the social thinking of Christian Laval and Pierre Dardot. Its main concern lies in the rise of new subjective arrangements within the context of neoliberalism. In order to think of these relationships, we have considered three conceptual traits derived from the works of the selected authors: the understanding of the crisis as a permanent way of life, the emphasis on the emotional aspects and on the performance/enjoyment device, and the reassignment of youth training to the territory of the common. Throughout the study, it is evidenced that an analytical, critical, and unorthodox framework, backed by a specific reinterpretation of Marx's thinking combined with other contributions, as treated by Dardot and Laval, displays a significant heuristic potentiality to think about the concepts of work, education, and youth in the current Brazilian context.

Resumen El presente estudio teórico propone un diagnóstico crítico de las relaciones entre trabajo, educación y juventud contemporánea, por medio de un breve diálogo con el pensamiento social de Christian Laval y Pierre Dardot. Su preocupación central se encuentra en la emergencia de nuevos arreglos subjetivos en el contexto del neoliberalismo. Para pensar tales relaciones fueron considerados tres trazos conceptuales derivados de las obras de los autores seleccionados: la comprensión de la crisis como modo de vida permanente, el énfasis en los aspectos emocionales y en el dispositivo desempeño/gozo y la reinscripción de la formación juvenil en el territorio del común. A lo largo del estudio, se muestra que un referencial analítico crítico y heterodoxo, sustentado en una relectura específica del pensamiento de Marx articulada a otras contribuciones, de la forma como tratado por Dardot y Laval, presenta potencialidad heurística significativa para pensar los conceptos de trabajo, educación y juventud en el contexto brasileño actual.

Revisitando a noção de justiça curricular: problematizações ao processo de seleção dos conhecimentos escolares / Revisiting the notion of curricular justice: problematizations the process of school knowledge selection

RESUMO: O presente artigo apresenta um estudo teórico acerca da noção de "justiça curricular", importante conceito para pensar as relações entre justiça social e educação no âmbito dos Estudos Curriculares. Em um contexto de intensificação das desigualdades educacionais, são revisadas, conceitualmente, algumas das principais obras sobre a temática da justiça curricular, em circulação no Brasil, dimensionando-as na interface de duas racionalidades predominantes, quais sejam: a redistribuição e o reconhecimento. Inspirado nos escritos políticos de Nancy Fraser, este artigo defenderá como aspecto central para o processo de seleção dos conhecimentos escolares uma forma de justiça curricular centrada nas dimensões da redistribuição, do reconhecimento e da representação. De acordo com o estudo desenvolvido, o conceito de justiça curricular, em sua potencialidade conceitual, pode ser um instrumento coletivo que nos permita promover a defesa da justiça escolar e da qualidade social da educação.

Abstract: This paper presents a theoretical study of the notion of "curricular justice", important concept to think the relationship between social justice and education within the Curriculum Studies. In a context of intensification of educational inequalities, some of the major works on the theme of curriculum justice in circulation in our country are reviewed, conceptually, placing them in two predominant rationales interface - the redistribution and recognition. Inspired by the political writings of Nancy Fraser, this article will defend, as central aspect to the process of school knowledge selection, a form of curricular justice focused on the dimensions of redistribution, recognition and representation. According to the study, the concept of curricular justice, in its conceptual potentiality, can be a collective instrument that allows us to promote the defense of school justice and the social quality of education.

Dimensões históricas das relações entre educação e Serviço Social: elementos para uma revisão crítica / Historical dimensions of relations between education and Social Work: elements for a critical review

Este estudo apresenta um conjunto de referências históricas acerca da relação Educação e Serviço Social, objetivando resgatar interfaces de origem das duas áreas do conhecimento e perceber como foi se estabelecendo a articulação entre a Educação como política pública e sua vinculação ao Serviço Social. Tomamos como materialidade investigativa referenciais teóricos da Educação e do Serviço Social e indicamos que, na constituição histórica das relações entre ambos, ocorrem significativas mudanças de ênfase nas racionalidades políticas e nas formas de intervenção, muito embora o debate sobre as proteções sociais e o combate às desigualdades seja uma constante.

This study presents a set of historical about the relationship Education and Social Work, aiming to rescue source interfaces of the two areas of knowledge and notice how it was establishing the link between Education as Public Policy and its linkage to the Social Work. We take as reference theoretical investigative materiality of Education and Social Work and indicate that, in the historical development of relations between both occur significant changes of emphasis in political rationalities and forms of intervention, although the discussion on social protection and the tackling inequalities it is a constant.

La biopiratería de los recursos de la medicina indígena tradicional en el estado Chiapas, México. El caso ICBG-Maya / Biopiracy of the resources of traditional indigenous medicine in the state of Chiapas, Mexico. The ICBG-Maya case

Este artículo pretende un breve análisis de la biopiratería experimentada y resistida por parte de los pueblos mayas de Chiapas. Para ello se da cuenta de acuerdos y normas internacionales para la protección de los recursos y conocimientos de los pueblos indígenas; las bases económicas y características, en los ámbitos mundial y nacional, que dan la pauta para la nueva ola de proyectos de bioprospección de los recursos vegetales de la medicina indígena tradicional, dirigida por los países del norte hacia los del sur; algunas experiencias de su implantación en Sudamérica y otros países subdesarrollados; se explican los elementos más importantes del proyecto de bioprospección denominado «Investigación farmacéutica y uso sustentable del conocimiento etnobotánico y biodiversidad en la Región Maya de Los Altos de Chiapas, México¼, que fue operado por parte de El Colegio de la Frontera Sur, Ecosur, la Universidad de Georgia ­con apoyo económico del gobierno de Estados Unidos­ y la compañía biotecnológica molecular Nature Limited de Gales, Reino Unido; por último, se describe la lucha que llevó a cabo el Consejo de Médicos y Parteras Indígenas Tradicionales de Chiapas, Compitch, para que fuera cancelado el mencionado proyecto, así como algunas propuestas alternativas de Compitch a este proyecto de biopiratería.