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Breast Cancer Res Treat ; 136(3): 907-9, 2012 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-23099437

RESUMEN

Recently, the HOXB13 gene has been shown to be a susceptibility gene for prostate cancer. HOXB13 is overexpressed in breast cancer tissues and HOXB13 expression in combination with low expression of IL17BR is predictive for a tamoxifen response in ER-positive breast cancers. Based on observations, we hypothesized that the HOXB13 p.Gly84Glu mutation might be associated with breast cancer risk. We genotyped this mutation in the germline DNA of 4,037 women with breast cancer (including 1,082 familial cases) and in 2,762 controls from Canada and Poland. Seven heterozygous carriers of the HOXB13 p.Gly84Glu mutation were found in the cases (0.17 %) compared to four carriers among the controls (0.14 %; OR = 1.2, 95 % CI = 0.34-4.1, p = 1.0). Only one of the seven carriers had a family history of breast cancer. This study does not support the hypothesis that women who carry the HOXB13 Gly84Glu mutation are at increased risk of breast cancer.


Asunto(s)
Neoplasias de la Mama/genética , Predisposición Genética a la Enfermedad , Proteínas de Homeodominio/genética , Mutación , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Canadá , Estudios de Casos y Controles , Femenino , Heterocigoto , Humanos , Persona de Mediana Edad , Polonia , Adulto Joven
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