RESUMEN
The antiviral and interferon-inducing activity of saparal, an adaptogen of plant origin, was studied. Tests in experimental mice demonstrated the interferon-inducing activity of saparal providing its antiviral effect. An optimal scheme of saparal administration was developed. The preparation had no direct inhibitory effect on influenza virus replication. The application of saparal for prophylaxis among workers resulted in a 2-fold or greater decrease of influenza and other ARD morbidity and in an increase of endogenous serum interferon level in 67-75% of the persons examined.
Asunto(s)
Antivirales/uso terapéutico , Virus de la Influenza A , Gripe Humana/tratamiento farmacológico , Inductores de Interferón/uso terapéutico , Extractos Vegetales/uso terapéutico , Animales , Células Cultivadas , Embrión de Pollo , Evaluación de Medicamentos , Evaluación Preclínica de Medicamentos , Humanos , Virus de la Influenza A/efectos de los fármacos , Gripe Humana/sangre , Gripe Humana/epidemiología , Gripe Humana/prevención & control , Interferones/sangre , Interferones/efectos de los fármacos , Ratones , Federación de Rusia/epidemiología , Estaciones del AñoRESUMEN
In four controlled observations on the organized groups of students and industrial workers during the epidemics of influenza A in 1988-1989 Arbidol, a new chemopreparation, was found to be well tolerated and to produce a pronounced prophylactic effect when administered in a dose of 0.2 g (2 tablets of 0.1 g) daily for 10-18 days. After the 18-day prophylactic course of Arbidol the induction of serum interferon was found.