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1.
Pyridodiazepine amines are selective therapeutic agents for helicobacter pylori by suppressing growth through inhibition of glutamate racemase but are predicted to require continuous elevated levels in plasma to achieve clinical efficacy.
Antimicrob Agents Chemother;
59(4): 2337-42, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25645840
2.
Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy.
Antimicrob Agents Chemother;
59(12): 7743-52, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26438502
3.
Discovery of heterocyclic sulfonamides as sphingosine 1-phosphate receptor 1 (S1P1) antagonists.
Bioorg Med Chem Lett;
25(10): 2041-5, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25890801
4.
Discovery of bacterial NADâº-dependent DNA ligase inhibitors: improvements in clearance of adenosine series.
Bioorg Med Chem Lett;
22(1): 85-9, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22154350
5.
Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.
J Med Chem;
58(17): 7057-75, 2015 Sep 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26291341
6.
Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).
J Med Chem;
56(24): 9897-919, 2013 Dec 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-24320998
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