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1.

ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.

Su, Wenjing; Mukherjee, Radha; Yaeger, Rona; Son, Jieun; Xu, Jianing; Na, Na; Merna Timaul, Neilawattie; Hechtman, Jaclyn; Paroder, Viktoriya; Lin, Mika; Mattar, Marissa; Qiu, Juan; Chang, Qing; Zhao, Huiyong; Zhang, Jonathan; Little, Megan; Adachi, Yuta; Han, Sae-Won; Taylor, Barry S; Ebi, Hiromichi; Abdel-Wahab, Omar; de Stanchina, Elisa; Rudin, Charles M; Jänne, Pasi A; McCormick, Frank; Yao, Zhan; Rosen, Neal.

Mol Cell; 82(13): 2443-2457.e7, 2022 07 07.

Artículo en Inglés | MEDLINE | ID: mdl-35613620

2.

Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis.

Mukherjee, Radha; Vanaja, Kiran G; Boyer, Jacob A; Gadal, Sunyana; Solomon, Hilla; Chandarlapaty, Sarat; Levchenko, Andre; Rosen, Neal.

Mol Cell; 81(4): 708-723.e5, 2021 02 18.

Artículo en Inglés | MEDLINE | ID: mdl-33606974

3.

Anatomic position determines oncogenic specificity in melanoma.

Weiss, Joshua M; Hunter, Miranda V; Cruz, Nelly M; Baggiolini, Arianna; Tagore, Mohita; Ma, Yilun; Misale, Sandra; Marasco, Michelangelo; Simon-Vermot, Theresa; Campbell, Nathaniel R; Newell, Felicity; Wilmott, James S; Johansson, Peter A; Thompson, John F; Long, Georgina V; Pearson, John V; Mann, Graham J; Scolyer, Richard A; Waddell, Nicola; Montal, Emily D; Huang, Ting-Hsiang; Jonsson, Philip; Donoghue, Mark T A; Harris, Christopher C; Taylor, Barry S; Xu, Tianhao; Chaligné, Ronan; Shliaha, Pavel V; Hendrickson, Ronald; Jungbluth, Achim A; Lezcano, Cecilia; Koche, Richard; Studer, Lorenz; Ariyan, Charlotte E; Solit, David B; Wolchok, Jedd D; Merghoub, Taha; Rosen, Neal; Hayward, Nicholas K; White, Richard M.

Nature; 604(7905): 354-361, 2022 04.

Artículo en Inglés | MEDLINE | ID: mdl-35355015

4.

Efficacy of MEK inhibition in patients with histiocytic neoplasms.

Diamond, Eli L; Durham, Benjamin H; Ulaner, Gary A; Drill, Esther; Buthorn, Justin; Ki, Michelle; Bitner, Lillian; Cho, Hana; Young, Robert J; Francis, Jasmine H; Rampal, Raajit; Lacouture, Mario; Brody, Lynn A; Ozkaya, Neval; Dogan, Ahmet; Rosen, Neal; Iasonos, Alexia; Abdel-Wahab, Omar; Hyman, David M.

Nature; 567(7749): 521-524, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-30867592

5.

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Lee, Bianca J; Boyer, Jacob A; Burnett, G Leslie; Thottumkara, Arun P; Tibrewal, Nidhi; Wilson, Stacy L; Hsieh, Tientien; Marquez, Abby; Lorenzana, Edward G; Evans, James W; Hulea, Laura; Kiss, Gert; Liu, Hui; Lee, Dong; Larsson, Ola; McLaughlan, Shannon; Topisirovic, Ivan; Wang, Zhengping; Wang, Zhican; Zhao, Yongyuan; Wildes, David; Aggen, James B; Singh, Mallika; Gill, Adrian L; Smith, Jacqueline A M; Rosen, Neal.

Nat Chem Biol; 17(10): 1065-1074, 2021 10.

Artículo en Inglés | MEDLINE | ID: mdl-34168367

6.

A Braf kinase-inactive mutant induces lung adenocarcinoma.

Nieto, Patricia; Ambrogio, Chiara; Esteban-Burgos, Laura; Gómez-López, Gonzalo; Blasco, María Teresa; Yao, Zhan; Marais, Richard; Rosen, Neal; Chiarle, Roberto; Pisano, David G; Barbacid, Mariano; Santamaría, David.

Nature; 548(7666): 239-243, 2017 08 10.

Artículo en Inglés | MEDLINE | ID: mdl-28783725

7.

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

Yao, Zhan; Yaeger, Rona; Rodrik-Outmezguine, Vanessa S; Tao, Anthony; Torres, Neilawattie M; Chang, Matthew T; Drosten, Matthias; Zhao, Huiyong; Cecchi, Fabiola; Hembrough, Todd; Michels, Judith; Baumert, Hervé; Miles, Linde; Campbell, Naomi M; de Stanchina, Elisa; Solit, David B; Barbacid, Mariano; Taylor, Barry S; Rosen, Neal.

Nature; 548(7666): 234-238, 2017 08 10.

Artículo en Inglés | MEDLINE | ID: mdl-28783719

8.

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.

Rodrik-Outmezguine, Vanessa S; Okaniwa, Masanori; Yao, Zhan; Novotny, Chris J; McWhirter, Claire; Banaji, Arpitha; Won, Helen; Wong, Wai; Berger, Mike; de Stanchina, Elisa; Barratt, Derek G; Cosulich, Sabina; Klinowska, Teresa; Rosen, Neal; Shokat, Kevan M.

Nature; 534(7606): 272-6, 2016 06 09.

Artículo en Inglés | MEDLINE | ID: mdl-27279227

9.

A combinatorial strategy for treating KRAS-mutant lung cancer.

Manchado, Eusebio; Weissmueller, Susann; Morris, John P; Chen, Chi-Chao; Wullenkord, Ramona; Lujambio, Amaia; de Stanchina, Elisa; Poirier, John T; Gainor, Justin F; Corcoran, Ryan B; Engelman, Jeffrey A; Rudin, Charles M; Rosen, Neal; Lowe, Scott W.

Nature; 534(7609): 647-51, 2016 06 30.

Artículo en Inglés | MEDLINE | ID: mdl-27338794

10.

Therapy-induced tumour secretomes promote resistance and tumour progression.

Obenauf, Anna C; Zou, Yilong; Ji, Andrew L; Vanharanta, Sakari; Shu, Weiping; Shi, Hubing; Kong, Xiangju; Bosenberg, Marcus C; Wiesner, Thomas; Rosen, Neal; Lo, Roger S; Massagué, Joan.

Nature; 520(7547): 368-72, 2015 Apr 16.

Artículo en Inglés | MEDLINE | ID: mdl-25807485

11.

Targeting Oncogenic RAS Protein.

Longo, Dan L; Rosen, Neal.

N Engl J Med; 387(2): 184-186, 2022 07 14.

Artículo en Inglés | MEDLINE | ID: mdl-35830646

12.

The sixth international RASopathies symposium: Precision medicine-From promise to practice.

Gripp, Karen W; Schill, Lisa; Schoyer, Lisa; Stronach, Beth; Bennett, Anton M; Blaser, Susan; Brown, Amanda; Burdine, Rebecca; Burkitt-Wright, Emma; Castel, Pau; Darilek, Sandra; Dias, Alwyn; Dyer, Tuesdi; Ellis, Michelle; Erickson, Gregg; Gelb, Bruce D; Green, Tamar; Gross, Andrea; Ho, Alan; Holder, James Lloyd; Inoue, Shin-Ichi; Jelin, Angie C; Kennedy, Annie; Klein, Richard; Kontaridis, Maria I; Magoulas, Pilar; McConnell, Darryl B; McCormick, Frank; Neel, Benjamin G; Prada, Carlos E; Rauen, Katherine A; Roberts, Amy; Rodriguez-Viciana, Pablo; Rosen, Neal; Rumbaugh, Gavin; Sablina, Anna; Solman, Maja; Tartaglia, Marco; Thomas, Angelica; Timmer, William C; Venkatachalam, Kartik; Walsh, Karin S; Wolters, Pamela L; Yi, Jae-Sung; Zenker, Martin; Ratner, Nancy.

Am J Med Genet A; 182(3): 597-606, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-31825160

13.

Finally, Effective Inhibitors of Mutant KRAS.

Rosen, Neal.

N Engl J Med; 384(25): 2447-2449, 2021 06 24.

Artículo en Inglés | MEDLINE | ID: mdl-34161711

14.

Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia.

Tiacci, Enrico; Park, Jae H; De Carolis, Luca; Chung, Stephen S; Broccoli, Alessandro; Scott, Sasinya; Zaja, Francesco; Devlin, Sean; Pulsoni, Alessandro; Chung, Young R; Cimminiello, Michele; Kim, Eunhee; Rossi, Davide; Stone, Richard M; Motta, Giovanna; Saven, Alan; Varettoni, Marzia; Altman, Jessica K; Anastasia, Antonella; Grever, Michael R; Ambrosetti, Achille; Rai, Kanti R; Fraticelli, Vincenzo; Lacouture, Mario E; Carella, Angelo M; Levine, Ross L; Leoni, Pietro; Rambaldi, Alessandro; Falzetti, Franca; Ascani, Stefano; Capponi, Monia; Martelli, Maria P; Park, Christopher Y; Pileri, Stefano A; Rosen, Neal; Foà, Robin; Berger, Michael F; Zinzani, Pier L; Abdel-Wahab, Omar; Falini, Brunangelo; Tallman, Martin S.

N Engl J Med; 373(18): 1733-47, 2015 Oct 29.

Artículo en Inglés | MEDLINE | ID: mdl-26352686

15.

Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Lee, Bianca J; Boyer, Jacob A; Burnett, G Leslie; Thottumkara, Arun P; Tibrewal, Nidhi; Wilson, Stacy L; Hsieh, Tientien; Marquez, Abby; Lorenzana, Edward G; Evans, James W; Hulea, Laura; Kiss, Gert; Liu, Hui; Lee, Dong; Larsson, Ola; McLaughlan, Shannon; Topisirovic, Ivan; Wang, Zhengping; Wang, Zhican; Zhao, Yongyuan; Wildes, David; Aggen, James B; Singh, Mallika; Gill, Adrian L; Smith, Jacqueline A M; Rosen, Neal.

Nat Chem Biol; 17(8): 925, 2021 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-34188221

16.

Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Lee, Bianca J; Boyer, Jacob A; Burnett, G Leslie; Thottumkara, Arun P; Tibrewal, Nidhi; Wilson, Stacy L; Hsieh, Tientien; Marquez, Abby; Lorenzana, Edward G; Evans, James W; Hulea, Laura; Kiss, Gert; Liu, Hui; Lee, Dong; Larsson, Ola; McLaughlan, Shannon; Topisirovic, Ivan; Wang, Zhengping; Wang, Zhican; Zhao, Yongyuan; Wildes, David; Aggen, James B; Singh, Mallika; Gill, Adrian L; Smith, Jacqueline A M; Rosen, Neal.

Nat Chem Biol; 17(11): 1209, 2021 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-34616097

17.

SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.

Durgan, Joanne; Tao, Guangbo; Walters, Matthew S; Florey, Oliver; Schmidt, Anja; Arbelaez, Vanessa; Rosen, Neal; Crystal, Ronald G; Hall, Alan.

EMBO Rep; 16(1): 87-96, 2015 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-25394671

18.

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).

Poulikakos, Poulikos I; Persaud, Yogindra; Janakiraman, Manickam; Kong, Xiangju; Ng, Charles; Moriceau, Gatien; Shi, Hubing; Atefi, Mohammad; Titz, Bjoern; Gabay, May Tal; Salton, Maayan; Dahlman, Kimberly B; Tadi, Madhavi; Wargo, Jennifer A; Flaherty, Keith T; Kelley, Mark C; Misteli, Tom; Chapman, Paul B; Sosman, Jeffrey A; Graeber, Thomas G; Ribas, Antoni; Lo, Roger S; Rosen, Neal; Solit, David B.

Nature; 480(7377): 387-90, 2011 Nov 23.

Artículo en Inglés | MEDLINE | ID: mdl-22113612

19.

Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.

She, Qing-Bai; Gruvberger-Saal, Sofia K; Maurer, Matthew; Chen, Yilun; Jumppanen, Mervi; Su, Tao; Dendy, Meaghan; Lau, Ying-Ka Ingar; Memeo, Lorenzo; Horlings, Hugo M; van de Vijver, Marc J; Isola, Jorma; Hibshoosh, Hanina; Rosen, Neal; Parsons, Ramon; Saal, Lao H.

BMC Cancer; 16: 587, 2016 08 02.

Artículo en Inglés | MEDLINE | ID: mdl-27484095

20.

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.

Poulikakos, Poulikos I; Zhang, Chao; Bollag, Gideon; Shokat, Kevan M; Rosen, Neal.

Nature; 464(7287): 427-30, 2010 Mar 18.

Artículo en Inglés | MEDLINE | ID: mdl-20179705

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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.

Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis.

Anatomic position determines oncogenic specificity in melanoma.

Efficacy of MEK inhibition in patients with histiocytic neoplasms.

Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

A Braf kinase-inactive mutant induces lung adenocarcinoma.

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.

A combinatorial strategy for treating KRAS-mutant lung cancer.

Therapy-induced tumour secretomes promote resistance and tumour progression.

Targeting Oncogenic RAS Protein.

The sixth international RASopathies symposium: Precision medicine-From promise to practice.

Finally, Effective Inhibitors of Mutant KRAS.

Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia.

Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

Author Correction: Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.

SOS1 and Ras regulate epithelial tight junction formation in the human airway through EMP1.

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).

Integrated molecular pathway analysis informs a synergistic combination therapy targeting PTEN/PI3K and EGFR pathways for basal-like breast cancer.

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.