Detalles de la búsqueda
1.
Development of the novel GlyT1 inhibitor, iclepertin (BI 425809), for the treatment of cognitive impairment associated with schizophrenia.
Eur Arch Psychiatry Clin Neurosci;
273(7): 1557-1566, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-36971864
2.
Effects of the Glycine Transporter-1 Inhibitor Iclepertin (BI 425809) on Sensory Processing, Neural Network Function, and Cognition in Animal Models Related to Schizophrenia.
J Pharmacol Exp Ther;
382(2): 223-232, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35661632
3.
Preclinical validation of the micropipette-guided drug administration (MDA) method in the maternal immune activation model of neurodevelopmental disorders.
Brain Behav Immun;
88: 461-470, 2020 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32278850
4.
The Novel Phosphodiesterase 9A Inhibitor BI 409306 Increases Cyclic Guanosine Monophosphate Levels in the Brain, Promotes Synaptic Plasticity, and Enhances Memory Function in Rodents.
J Pharmacol Exp Ther;
371(3): 633-641, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31578258
5.
Overexpression of Protein Kinase Mζ in the Hippocampus Enhances Long-Term Potentiation and Long-Term Contextual But Not Cued Fear Memory in Rats.
J Neurosci;
36(15): 4313-24, 2016 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27076427
6.
Pharmaceutical Characterization of Tropomyosin Receptor Kinase B-Agonistic Antibodies on Human Induced Pluripotent Stem (hiPS) Cell-Derived Neurons.
J Pharmacol Exp Ther;
361(3): 355-365, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28351853
7.
Age-related synaptic dysfunction in Tg2576 mice starts as a failure in early long-term potentiation which develops into a full abolishment of late long-term potentiation.
J Neurosci Res;
94(3): 266-81, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26629777
8.
Touchscreen tasks in mice to demonstrate differences between hippocampal and striatal functions.
Neurobiol Learn Mem;
120: 16-27, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25687692
9.
Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus.
Synapse;
69(10): 484-96, 2015 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26178667
10.
Neuroimaging Biomarkers for Drug Discovery and Development in Schizophrenia.
Biol Psychiatry;
2024 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38272287
11.
Globular and protofibrillar aß aggregates impair neurotransmission by different mechanisms.
Biochemistry;
52(8): 1466-76, 2013 Feb 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-23374097
12.
Effects of the mGlu2/3 receptor agonist LY379268 on two models of disturbed auditory evoked brain oscillations in mice.
Transl Psychiatry;
13(1): 150, 2023 05 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37147311
13.
Quantitative electroencephalography parameters as neurophysiological biomarkers of schizophrenia-related deficits: A Phase II substudy of patients treated with iclepertin (BI 425809).
Transl Psychiatry;
12(1): 329, 2022 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35953474
14.
Increasing the Excitatory Drive Rescues Excitatory/Inhibitory Imbalance and Mismatch Negativity Deficit Caused by Parvalbumin Specific GluA1 Deletion.
Neuroscience;
496: 190-204, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35750109
15.
Pro-cognitive effects of the GlyT1 inhibitor Bitopertin in rodents.
Eur J Pharmacol;
935: 175306, 2022 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-36183855
16.
Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor.
Eur J Drug Metab Pharmacokinet;
47(1): 91-103, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34716565
17.
Symptomatic and preventive effects of the novel phosphodiesterase-9 inhibitor BI 409306 in an immune-mediated model of neurodevelopmental disorders.
Neuropsychopharmacology;
46(8): 1526-1534, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33941860
18.
A randomized Phase II trial evaluating efficacy, safety, and tolerability of oral BI 409306 in attenuated psychosis syndrome: Design and rationale.
Early Interv Psychiatry;
15(5): 1315-1325, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33354862
19.
Suppression of Parvalbumin Interneuron Activity in the Prefrontal Cortex Recapitulates Features of Impaired Excitatory/Inhibitory Balance and Sensory Processing in Schizophrenia.
Schizophr Bull;
46(4): 981-989, 2020 07 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31903492
20.
Automated classification of the behavior of rats in the forced swimming test with support vector machines.
Neural Netw;
21(1): 92-101, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18158234