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1.

Successes in antiviral drug discovery: a tribute to Nick Meanwell.

Rotella, David P.

Med Chem Res; : 1-10, 2023 Jun 08.

Artículo en Inglés | MEDLINE | ID: mdl-37362321

2.

Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.

Eck, Tyler; Laureano de Souza, Mariana; Delvillar, Melvin; Ashraf, Kutub; Yadav Bheemanaboina, Rammohan R; Chakrasali, Ramappa; Kreiss, Tamara; Siekierka, John J; Rotella, David P; Bhanot, Purnima; Goodey, Nina M.

Chembiochem; 23(7): e202100704, 2022 04 05.

Artículo en Inglés | MEDLINE | ID: mdl-35044710

3.

Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds.

Minnow, Yacoba V T; Goldberg, Ronald; Tummalapalli, Sreedhar R; Rotella, David P; Goodey, Nina M.

Arch Biochem Biophys; 618: 15-22, 2017 03 15.

Artículo en Inglés | MEDLINE | ID: mdl-28137423

4.

Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors.

Bhat, Rohit; Adam, Amna T; Lee, Jungeun Jasmine; Deloison, Gaspard; Rouillé, Yves; Séron, Karin; Rotella, David P.

Bioorg Med Chem Lett; 24(17): 4162-5, 2014 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-25103601

5.

Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors.

Bhat, Rohit; Adam, Amna T; Lee, Jungeun Jasmine; Gasiewicz, Thomas A; Henry, Ellen C; Rotella, David P.

Bioorg Med Chem Lett; 24(10): 2263-6, 2014 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-24745965

6.

Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.

Gilleran, John A; Ashraf, Kutub; Delvillar, Melvin; Eck, Tyler; Fondekar, Raheel; Miller, Edward B; Hutchinson, Ashley; Dong, Aiping; Seitova, Alma; De Souza, Mariana Laureano; Augeri, David; Halabelian, Levon; Siekierka, John; Rotella, David P; Gordon, John; Childers, Wayne E; Grier, Mark C; Staker, Bart L; Roberge, Jacques Y; Bhanot, Purnima.

J Med Chem; 67(5): 3467-3503, 2024 Mar 14.

Artículo en Inglés | MEDLINE | ID: mdl-38372781

7.

First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline.

Mahmood, Shams Ul; Lozano Gonzalez, Mariana; Tummalapalli, Sreedhar; Eberhard, Jeremy; Ly, Judy; Hoffman, Charles S; Kelly, Michy P; Gordon, John; Colussi, Dennis; Childers, Wayne; Rotella, David P.

J Med Chem; 66(21): 14597-14608, 2023 11 09.

Artículo en Inglés | MEDLINE | ID: mdl-37862143

8.

Recent results in protein kinase inhibition for tropical diseases.

Rotella, David P.

Bioorg Med Chem Lett; 22(22): 6788-93, 2012 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-23063403

9.

Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.

Bheemanaboina, Rammohan R Yadav; de Souza, Mariana Laureano; Gonzalez, Mariana Lozano; Mahmood, Shams Ul; Eck, Tyler; Kreiss, Tamara; Aylor, Samantha O; Roth, Alison; Lee, Patricia; Pybus, Brandon S; Colussi, Dennis J; Childers, Wayne E; Gordon, John; Siekierka, John J; Bhanot, Purnima; Rotella, David P.

ACS Med Chem Lett; 12(12): 1962-1967, 2021 Dec 09.

Artículo en Inglés | MEDLINE | ID: mdl-34917261

10.

Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia.

Yan, Yinfa; Zhou, Ping; Rotella, David P; Feenstra, Rolf; Kruse, Chris G; Reinders, Jan-Hendrik; van der Neut, Martina; Lai, Margaret; Zhang, Jean; Kowal, Dianne M; Carrick, Tikva; Marquis, Karen L; Pausch, Mark H; Robichaud, Albert J.

Bioorg Med Chem Lett; 20(9): 2983-6, 2010 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-20347298

11.

Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase.

Mahmood, Shams Ul; Cheng, Huimin; Tummalapalli, Sreedhar R; Chakrasali, Ramappa; Yadav Bheemanaboina, Rammohan R; Kreiss, Tamara; Chojnowski, Agnieska; Eck, Tyler; Siekierka, John J; Rotella, David P.

RSC Med Chem; 11(1): 98-101, 2020 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-33479608

12.

Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.

Rotella, David P; McFarlane, Geraldine R; Greenfield, Alexander; Grosanu, Cristina; Robichaud, Albert J; Denny, Rajiah Aldrin; Feenstra, Rolf W; Núñez-García, Sara; Reinders, Jan-Hendrik; Neut, Martina van der; McCreary, Andrew; Kruse, Chris G; Sullivan, Kelly; Pruthi, Farhana; Lai, Margaret; Zhang, Jean; Kowal, Dianne M; Carrick, Tikva; Grauer, Steven M; Navarra, Rachel L; Graf, Radka; Brennan, Julie; Marquis, Karen L; Pausch, Mark H.

Bioorg Med Chem Lett; 19(19): 5552-5, 2009 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-19720528

13.

Patrick M. Woster Memorial Commentary.

Rotella, David P; Georg, Gunda.

ACS Med Chem Lett; 14(10): 1305-1309, 2023 Oct 12.

Artículo en Inglés | MEDLINE | ID: mdl-37849535

14.

Patrick M. Woster Memorial Commentary.

Rotella, David P; Georg, Gunda.

J Med Chem; 66(18): 12645-12649, 2023 09 28.

Artículo en Inglés | MEDLINE | ID: mdl-37681287

15.

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis.

Tummalapalli, Sreedhar R; Bhat, Rohit; Chojnowski, Agnieszka; Prorok, Monika; Kreiss, Tamara; Goldberg, Ronald; Canan, Stacie; Hawryluk, Natalie; Mortensen, Deborah; Khetani, Vikram; Zeldis, Jerome; Siekierka, John J; Rotella, David P.

ACS Med Chem Lett; 9(3): 210-214, 2018 Mar 08.

Artículo en Inglés | MEDLINE | ID: mdl-29541362

16.

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti.

Tobias, Andrew M; Toska, Dea; Lange, Keith; Eck, Tyler; Bhat, Rohit; Janson, Cheryl A; Rotella, David P; Gubler, Ueli; Goodey, Nina M.

PLoS One; 13(5): e0197173, 2018.

Artículo en Inglés | MEDLINE | ID: mdl-29787565

17.

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.

Simpkins, Ligaya M; Bolton, Scott; Pi, Zulan; Sutton, James C; Kwon, Chet; Zhao, Guohua; Magnin, David R; Augeri, David J; Gungor, Timur; Rotella, David P; Sun, Zhong; Liu, Yajun; Slusarchyk, William S; Marcinkeviciene, Jovita; Robertson, James G; Wang, Aiying; Robl, Jeffrey A; Atwal, Karnail S; Zahler, Robert L; Parker, Rex A; Kirby, Mark S; Hamann, Lawrence G.

Bioorg Med Chem Lett; 17(23): 6476-80, 2007 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-17937986

18.

Phosphodiesterase 5 inhibitors: current status and potential applications.

Rotella, David P.

Nat Rev Drug Discov; 1(9): 674-82, 2002 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-12209148

19.

The Critical Role of Organic Chemistry in Drug Discovery.

Rotella, David P.

ACS Chem Neurosci; 7(10): 1315-1316, 2016 10 19.

Artículo en Inglés | MEDLINE | ID: mdl-27623164

20.

Osteoporosis: challenges and new opportunities for therapy.

Rotella, David P.

Curr Opin Drug Discov Devel; 5(4): 477-86, 2002 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-12197306

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Successes in antiviral drug discovery: a tribute to Nick Meanwell.

Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.

Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds.

Structure-activity studies of (-)-epigallocatechin gallate derivatives as HCV entry inhibitors.

Towards the discovery of drug-like epigallocatechin gallate analogs as Hsp90 inhibitors.

Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.

First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline.

Recent results in protein kinase inhibition for tropical diseases.

Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.

Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia.

Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase.

Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia.

Patrick M. Woster Memorial Commentary.

Patrick M. Woster Memorial Commentary.

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis.

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti.

Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors.

Phosphodiesterase 5 inhibitors: current status and potential applications.

The Critical Role of Organic Chemistry in Drug Discovery.

Osteoporosis: challenges and new opportunities for therapy.