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1.

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport.

Zhang, Ke; Daigle, J Gavin; Cunningham, Kathleen M; Coyne, Alyssa N; Ruan, Kai; Grima, Jonathan C; Bowen, Kelly E; Wadhwa, Harsh; Yang, Peiguo; Rigo, Frank; Taylor, J Paul; Gitler, Aaron D; Rothstein, Jeffrey D; Lloyd, Thomas E.

Cell; 173(4): 958-971.e17, 2018 05 03.

Artículo en Inglés | MEDLINE | ID: mdl-29628143

2.

Edaravone: A new drug approved for ALS.

Rothstein, Jeffrey D.

Cell; 171(4): 725, 2017 Nov 02.

Artículo en Inglés | MEDLINE | ID: mdl-29100067

3.

Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

Watson, McLane J; Vignali, Paolo D A; Mullett, Steven J; Overacre-Delgoffe, Abigail E; Peralta, Ronal M; Grebinoski, Stephanie; Menk, Ashley V; Rittenhouse, Natalie L; DePeaux, Kristin; Whetstone, Ryan D; Vignali, Dario A A; Hand, Timothy W; Poholek, Amanda C; Morrison, Brett M; Rothstein, Jeffrey D; Wendell, Stacy G; Delgoffe, Greg M.

Nature; 591(7851): 645-651, 2021 03.

Artículo en Inglés | MEDLINE | ID: mdl-33589820

4.

Apilimod dimesylate in C9orf72 amyotrophic lateral sclerosis: a randomized phase 2a clinical trial.

Babu, Suma; Nicholson, Katharine A; Rothstein, Jeffrey D; Swenson, Andrea; Sampognaro, Paul J; Pant, Pravin; Macklin, Eric A; Spruill, Susan; Paganoni, Sabrina; Gendron, Tania F; Prudencio, Mercedes; Petrucelli, Leonard; Nix, Darrell; Landrette, Sean; Nkrumah, Esther; Fandrick, Keith; Edwards, Joan; Young, Peter R.

Brain; 2024 Apr 12.

Artículo en Inglés | MEDLINE | ID: mdl-38606777

5.

Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.

Paganoni, Sabrina; Macklin, Eric A; Hendrix, Suzanne; Berry, James D; Elliott, Michael A; Maiser, Samuel; Karam, Chafic; Caress, James B; Owegi, Margaret A; Quick, Adam; Wymer, James; Goutman, Stephen A; Heitzman, Daragh; Heiman-Patterson, Terry; Jackson, Carlayne E; Quinn, Colin; Rothstein, Jeffrey D; Kasarskis, Edward J; Katz, Jonathan; Jenkins, Liberty; Ladha, Shafeeq; Miller, Timothy M; Scelsa, Stephen N; Vu, Tuan H; Fournier, Christina N; Glass, Jonathan D; Johnson, Kristin M; Swenson, Andrea; Goyal, Namita A; Pattee, Gary L; Andres, Patricia L; Babu, Suma; Chase, Marianne; Dagostino, Derek; Dickson, Samuel P; Ellison, Noel; Hall, Meghan; Hendrix, Kent; Kittle, Gale; McGovern, Michelle; Ostrow, Joseph; Pothier, Lindsay; Randall, Rebecca; Shefner, Jeremy M; Sherman, Alexander V; Tustison, Eric; Vigneswaran, Prasha; Walker, Jason; Yu, Hong; Chan, James.

N Engl J Med; 383(10): 919-930, 2020 09 03.

Artículo en Inglés | MEDLINE | ID: mdl-32877582

6.

G₂C₄ targeting antisense oligonucleotides potently mitigate TDP-43 dysfunction in human C9orf72 ALS/FTD induced pluripotent stem cell derived neurons.

Rothstein, Jeffrey D; Baskerville, Victoria; Rapuri, Sampath; Mehlhop, Emma; Jafar-Nejad, Paymaan; Rigo, Frank; Bennett, Frank; Mizielinska, Sarah; Isaacs, Adrian; Coyne, Alyssa N.

Acta Neuropathol; 147(1): 1, 2023 11 29.

Artículo en Inglés | MEDLINE | ID: mdl-38019311

7.

Effect of sodium phenylbutyrate/taurursodiol on tracheostomy/ventilation-free survival and hospitalisation in amyotrophic lateral sclerosis: long-term results from the CENTAUR trial.

Paganoni, Sabrina; Hendrix, Suzanne; Dickson, Samuel P; Knowlton, Newman; Berry, James D; Elliott, Michael A; Maiser, Samuel; Karam, Chafic; Caress, James B; Owegi, Margaret Ayo; Quick, Adam; Wymer, James; Goutman, Stephen A; Heitzman, Daragh; Heiman-Patterson, Terry D; Jackson, Carlayne; Quinn, Colin; Rothstein, Jeffrey D; Kasarskis, Edward J; Katz, Jonathan; Jenkins, Liberty; Ladha, Shafeeq S; Miller, Timothy M; Scelsa, Stephen N; Vu, Tuan H; Fournier, Christina; Johnson, Kristin M; Swenson, Andrea; Goyal, Namita; Pattee, Gary L; Babu, Suma; Chase, Marianne; Dagostino, Derek; Hall, Meghan; Kittle, Gale; Eydinov, Mathew; Ostrow, Joseph; Pothier, Lindsay; Randall, Rebecca; Shefner, Jeremy M; Sherman, Alexander V; Tustison, Eric; Vigneswaran, Prasha; Yu, Hong; Cohen, Joshua; Klee, Justin; Tanzi, Rudolph; Gilbert, Walter; Yeramian, Patrick; Cudkowicz, Merit.

J Neurol Neurosurg Psychiatry; 2022 May 16.

Artículo en Inglés | MEDLINE | ID: mdl-35577511

8.

A Helicase Unwinds Hexanucleotide Repeat RNA G-Quadruplexes and Facilitates Repeat-Associated Non-AUG Translation.

Liu, Honghe; Lu, Yu-Ning; Paul, Tapas; Periz, Goran; Banco, Michael T; Ferré-D'Amaré, Adrian R; Rothstein, Jeffrey D; Hayes, Lindsey R; Myong, Sua; Wang, Jiou.

J Am Chem Soc; 143(19): 7368-7379, 2021 05 19.

Artículo en Inglés | MEDLINE | ID: mdl-33855846

9.

The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease.

Haeusler, Aaron R; Donnelly, Christopher J; Rothstein, Jeffrey D.

Nat Rev Neurosci; 17(6): 383-95, 2016 06.

Artículo en Inglés | MEDLINE | ID: mdl-27150398

10.

Long-term survival of participants in the CENTAUR trial of sodium phenylbutyrate-taurursodiol in amyotrophic lateral sclerosis.

Paganoni, Sabrina; Hendrix, Suzanne; Dickson, Samuel P; Knowlton, Newman; Macklin, Eric A; Berry, James D; Elliott, Michael A; Maiser, Samuel; Karam, Chafic; Caress, James B; Owegi, Margaret Ayo; Quick, Adam; Wymer, James; Goutman, Stephen A; Heitzman, Daragh; Heiman-Patterson, Terry D; Jackson, Carlayne E; Quinn, Colin; Rothstein, Jeffrey D; Kasarskis, Edward J; Katz, Jonathan; Jenkins, Liberty; Ladha, Shafeeq; Miller, Timothy M; Scelsa, Stephen N; Vu, Tuan H; Fournier, Christina N; Glass, Jonathan D; Johnson, Kristin M; Swenson, Andrea; Goyal, Namita A; Pattee, Gary L; Andres, Patricia L; Babu, Suma; Chase, Marianne; Dagostino, Derek; Hall, Meghan; Kittle, Gale; Eydinov, Matthew; McGovern, Michelle; Ostrow, Joseph; Pothier, Lindsay; Randall, Rebecca; Shefner, Jeremy M; Sherman, Alexander V; St Pierre, Maria E; Tustison, Eric; Vigneswaran, Prasha; Walker, Jason; Yu, Hong.

Muscle Nerve; 63(1): 31-39, 2021 01.

Artículo en Inglés | MEDLINE | ID: mdl-33063909

11.

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.

Zhang, Ke; Donnelly, Christopher J; Haeusler, Aaron R; Grima, Jonathan C; Machamer, James B; Steinwald, Peter; Daley, Elizabeth L; Miller, Sean J; Cunningham, Kathleen M; Vidensky, Svetlana; Gupta, Saksham; Thomas, Michael A; Hong, Ingie; Chiu, Shu-Ling; Huganir, Richard L; Ostrow, Lyle W; Matunis, Michael J; Wang, Jiou; Sattler, Rita; Lloyd, Thomas E; Rothstein, Jeffrey D.

Nature; 525(7567): 56-61, 2015 Sep 03.

Artículo en Inglés | MEDLINE | ID: mdl-26308891

12.

Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging.

Jha, Mithilesh Kumar; Lee, Youngjin; Russell, Katelyn A; Yang, Fang; Dastgheyb, Raha M; Deme, Pragney; Ament, Xanthe H; Chen, Weiran; Liu, Ying; Guan, Yun; Polydefkis, Michael J; Hoke, Ahmet; Haughey, Norman J; Rothstein, Jeffrey D; Morrison, Brett M.

Glia; 68(1): 161-177, 2020 01.

Artículo en Inglés | MEDLINE | ID: mdl-31453649

13.

Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells.

Perkins, Emma M; Clarkson, Yvonne L; Suminaite, Daumante; Lyndon, Alastair R; Tanaka, Kohichi; Rothstein, Jeffrey D; Skehel, Paul A; Wyllie, David J A; Jackson, Mandy.

Hum Mol Genet; 27(15): 2614-2627, 2018 08 01.

Artículo en Inglés | MEDLINE | ID: mdl-29741614

14.

Astrocyte Diversity: Current Insights and Future Directions.

Westergard, Thomas; Rothstein, Jeffrey D.

Neurochem Res; 45(6): 1298-1305, 2020 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-32006215

15.

Amyotrophic lateral sclerosis care and research in the United States during the COVID-19 pandemic: Challenges and opportunities.

Andrews, Jinsy A; Berry, James D; Baloh, Robert H; Carberry, Nathan; Cudkowicz, Merit E; Dedi, Brixhilda; Glass, Jonathan; Maragakis, Nicholas J; Miller, Timothy M; Paganoni, Sabrina; Rothstein, Jeffrey D; Shefner, Jeremy M; Simmons, Zachary; Weiss, Michael D; Bedlack, Richard S.

Muscle Nerve; 62(2): 182-186, 2020 08.

Artículo en Inglés | MEDLINE | ID: mdl-32445195

16.

C9orf72 nucleotide repeat structures initiate molecular cascades of disease.

Haeusler, Aaron R; Donnelly, Christopher J; Periz, Goran; Simko, Eric A J; Shaw, Patrick G; Kim, Min-Sik; Maragakis, Nicholas J; Troncoso, Juan C; Pandey, Akhilesh; Sattler, Rita; Rothstein, Jeffrey D; Wang, Jiou.

Nature; 507(7491): 195-200, 2014 Mar 13.

Artículo en Inglés | MEDLINE | ID: mdl-24598541

17.

Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis.

Hoye, Mariah L; Regan, Melissa R; Jensen, Leah A; Lake, Allison M; Reddy, Linga V; Vidensky, Svetlana; Richard, Jean-Philippe; Maragakis, Nicholas J; Rothstein, Jeffrey D; Dougherty, Joseph D; Miller, Timothy M.

Brain; 141(9): 2561-2575, 2018 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-30007309

18.

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.

Le, Nhat T T; Chang, Lydia; Kovlyagina, Irina; Georgiou, Polymnia; Safren, Nathaniel; Braunstein, Kerstin E; Kvarta, Mark D; Van Dyke, Adam M; LeGates, Tara A; Philips, Thomas; Morrison, Brett M; Thompson, Scott M; Puche, Adam C; Gould, Todd D; Rothstein, Jeffrey D; Wong, Philip C; Monteiro, Mervyn J.

Proc Natl Acad Sci U S A; 113(47): E7580-E7589, 2016 11 22.

Artículo en Inglés | MEDLINE | ID: mdl-27834214

19.

Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of ß-III spectrin and GLAST.

Perkins, Emma M; Suminaite, Daumante; Clarkson, Yvonne L; Lee, Sin Kwan; Lyndon, Alastair R; Rothstein, Jeffrey D; Wyllie, David J A; Tanaka, Kohichi; Jackson, Mandy.

Hum Mol Genet; 25(20): 4448-4461, 2016 10 15.

Artículo en Inglés | MEDLINE | ID: mdl-28173092

20.

Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model.

Miller, Sean J; Glatzer, Jenna C; Hsieh, Yi-Chun; Rothstein, Jeffrey D.

J Neurogenet; 32(4): 322-335, 2018 12.

Artículo en Inglés | MEDLINE | ID: mdl-30398075

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