Detalles de la búsqueda
1.
Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone.
Molecules;
28(2)2023 Jan 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36677690
2.
Chemical synthesis of fluorinated and iodinated 17ß-HSD3 inhibitors and evaluation for imaging prostate cancer tumors and tissue biodistribution.
Bioorg Chem;
129: 106145, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36174444
3.
Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel.
Int J Mol Sci;
22(20)2021 Oct 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34681843
4.
Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17ß-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen.
Bioorg Med Chem Lett;
30(2): 126783, 2020 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31753699
5.
Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging.
Bioorg Med Chem;
28(7): 115368, 2020 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32122754
6.
Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model.
Invest New Drugs;
37(3): 431-440, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30062573
7.
Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17ß-hydroxysteroid dehydrogenase type 10.
Bioorg Med Chem Lett;
28(22): 3554-3559, 2018 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30297283
8.
Impact of androstane A- and D-ring inversion on 17ß-hydroxysteroid dehydrogenase type 3 inhibitory activity, androgenic effect and metabolic stability.
Bioorg Med Chem;
25(7): 2065-2073, 2017 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28254377
9.
Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives.
Bioorg Med Chem Lett;
26(21): 5272-5276, 2016 11 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27687674
10.
Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17ß-hydroxysteroid dehydrogenase type 3.
Bioorg Med Chem;
23(17): 5433-51, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26277760
11.
Synthesis of 3-spiromorpholinone androsterone derivatives as inhibitors of 17ß-hydroxysteroid dehydrogenase type 3.
Bioorg Med Chem Lett;
23(23): 6360-2, 2013 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24144853
12.
Synthesis of 5α-androstane-17-spiro-δ-lactones with a 3-keto, 3-hydroxy, 3-spirocarbamate or 3-spiromorpholinone as inhibitors of 17ß-hydroxysteroid dehydrogenases.
Molecules;
18(1): 914-33, 2013 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23344201
13.
An Aminosteroid Derivative Shows Higher In Vitro and In Vivo Potencies than Gold Standard Drugs in Androgen-Dependent Prostate Cancer Models.
Cancers (Basel);
15(11)2023 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37296995
14.
Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments.
J Clin Med;
12(13)2023 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-37445276
15.
A novel aminosteroid of the 5α-androstane-3α,17ß-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells.
Invest New Drugs;
30(1): 176-85, 2012 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-20890632
16.
Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines.
Anticancer Drugs;
23(8): 803-14, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22361842
17.
Chemical synthesis, NMR characterization, and anticancer activity of androstene derivatives with a C17-side chain.
Steroids;
186: 109064, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-35714784
18.
An irreversible inhibitor of 17ß-hydroxysteroid dehydrogenase type 1 inhibits estradiol synthesis in human endometriosis lesions and induces regression of the non-human primate endometriosis.
J Steroid Biochem Mol Biol;
222: 106136, 2022 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35691460
19.
Libraries of 2ß-(N-substituted piperazino)-5α-androstane-3α, 17ß-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes.
Mol Divers;
15(2): 317-39, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20827507
20.
Turning a Quinoline-based Steroidal Anticancer Agent into Fluorescent Dye for its Tracking by Cell Imaging.
ACS Med Chem Lett;
12(5): 822-826, 2021 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34055232