Detalles de la búsqueda
1.
Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association.
Circulation;
136(3): e1-e23, 2017 Jul 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28620111
2.
Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2.
Circ Res;
115(10): 826-33, 2014 Oct 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-25239141
3.
Targeted Knockdown of Hepatic SOAT2 With Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr-/- Mice.
Arterioscler Thromb Vasc Biol;
35(9): 1920-7, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26229140
4.
Localization of APOL1 protein and mRNA in the human kidney: nondiseased tissue, primary cells, and immortalized cell lines.
J Am Soc Nephrol;
26(2): 339-48, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25012173
5.
PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice.
J Pharmacol Exp Ther;
355(2): 159-67, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26283692
6.
New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.
J Pharmacol Exp Ther;
355(2): 299-307, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26338984
7.
Transmembrane protein 55B is a novel regulator of cellular cholesterol metabolism.
Arterioscler Thromb Vasc Biol;
34(9): 1917-23, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-25035345
8.
Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs.
J Lipid Res;
55(11): 2261-75, 2014 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25030663
9.
Phytosterol feeding causes toxicity in ABCG5/G8 knockout mice.
Am J Pathol;
182(4): 1131-8, 2013 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-23380580
10.
ACAT inhibition reduces the progression of preexisting, advanced atherosclerotic mouse lesions without plaque or systemic toxicity.
Arterioscler Thromb Vasc Biol;
33(1): 4-12, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23139293
11.
LDL particle core enrichment in cholesteryl oleate increases proteoglycan binding and promotes atherosclerosis.
J Lipid Res;
54(9): 2495-503, 2013 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-23804810
12.
Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice.
J Lipid Res;
54(6): 1567-1577, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23564696
13.
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.
Bioorg Med Chem Lett;
23(9): 2659-62, 2013 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23535327
14.
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.
Bioorg Med Chem Lett;
23(13): 3798-801, 2013 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23711919
15.
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.
Bioorg Med Chem Lett;
23(5): 1285-7, 2013 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23369538
16.
Cholesterol esterification by ACAT2 is essential for efficient intestinal cholesterol absorption: evidence from thoracic lymph duct cannulation.
J Lipid Res;
53(1): 95-104, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22045928
17.
ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation.
J Lipid Res;
53(8): 1598-609, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22669916
18.
Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood.
J Lipid Res;
53(6): 1144-52, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22460046
19.
Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.
Arterioscler Thromb Vasc Biol;
31(5): 1108-15, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21393580
20.
Dyslipidemia induces opposing effects on intrapulmonary and extrapulmonary host defense through divergent TLR response phenotypes.
J Immunol;
185(3): 1660-9, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20581153