Búsqueda | Portal de Búsqueda de la BVS España

1.

Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.

Shen, Kuang; Rogala, Kacper B; Chou, Hui-Ting; Huang, Rick K; Yu, Zhiheng; Sabatini, David M.

Cell; 179(6): 1319-1329.e8, 2019 11 27.

Artículo en Inglés | MEDLINE | ID: mdl-31704029

2.

Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease.

Liu, Grace Y; Sabatini, David M.

Nat Rev Mol Cell Biol; 21(4): 246, 2020 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-32005970

3.

mTOR at the nexus of nutrition, growth, ageing and disease.

Liu, Grace Y; Sabatini, David M.

Nat Rev Mol Cell Biol; 21(4): 183-203, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-31937935

4.

mTOR Signaling in Growth, Metabolism, and Disease.

Saxton, Robert A; Sabatini, David M.

Cell; 168(6): 960-976, 2017 03 09.

Artículo en Inglés | MEDLINE | ID: mdl-28283069

5.

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

Wang, Tim; Yu, Haiyan; Hughes, Nicholas W; Liu, Bingxu; Kendirli, Arek; Klein, Klara; Chen, Walter W; Lander, Eric S; Sabatini, David M.

Cell; 168(5): 890-903.e15, 2017 02 23.

Artículo en Inglés | MEDLINE | ID: mdl-28162770

6.

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

Cantor, Jason R; Abu-Remaileh, Monther; Kanarek, Naama; Freinkman, Elizaveta; Gao, Xin; Louissaint, Abner; Lewis, Caroline A; Sabatini, David M.

Cell; 169(2): 258-272.e17, 2017 Apr 06.

Artículo en Inglés | MEDLINE | ID: mdl-28388410

7.

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

Wyant, Gregory A; Abu-Remaileh, Monther; Wolfson, Rachel L; Chen, Walter W; Freinkman, Elizaveta; Danai, Laura V; Vander Heiden, Matthew G; Sabatini, David M.

Cell; 171(3): 642-654.e12, 2017 Oct 19.

Artículo en Inglés | MEDLINE | ID: mdl-29053970

8.

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.

Chen, Walter W; Freinkman, Elizaveta; Wang, Tim; Birsoy, Kivanç; Sabatini, David M.

Cell; 166(5): 1324-1337.e11, 2016 Aug 25.

Artículo en Inglés | MEDLINE | ID: mdl-27565352

9.

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.

Chantranupong, Lynne; Scaria, Sonia M; Saxton, Robert A; Gygi, Melanie P; Shen, Kuang; Wyant, Gregory A; Wang, Tim; Harper, J Wade; Gygi, Steven P; Sabatini, David M.

Cell; 165(1): 153-164, 2016 Mar 24.

Artículo en Inglés | MEDLINE | ID: mdl-26972053

10.

Nutrient-sensing mechanisms across evolution.

Chantranupong, Lynne; Wolfson, Rachel L; Sabatini, David M.

Cell; 161(1): 67-83, 2015 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-25815986

11.

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Birsoy, Kivanç; Wang, Tim; Chen, Walter W; Freinkman, Elizaveta; Abu-Remaileh, Monther; Sabatini, David M.

Cell; 162(3): 540-51, 2015 Jul 30.

Artículo en Inglés | MEDLINE | ID: mdl-26232224

12.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul, Yoav D; Freinkman, Elizaveta; Comb, William C; Cantor, Jason R; Tam, Wai Leong; Thiru, Prathapan; Kim, Dohoon; Kanarek, Naama; Pacold, Michael E; Chen, Walter W; Bierie, Brian; Possemato, Richard; Reinhardt, Ferenc; Weinberg, Robert A; Yaffe, Michael B; Sabatini, David M.

Cell; 158(5): 1094-1109, 2014 Aug 28.

Artículo en Inglés | MEDLINE | ID: mdl-25171410

13.

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.

Gu, Xin; Jouandin, Patrick; Lalgudi, Pranav V; Binari, Rich; Valenstein, Max L; Reid, Michael A; Allen, Annamarie E; Kamitaki, Nolan; Locasale, Jason W; Perrimon, Norbert; Sabatini, David M.

Nature; 608(7921): 209-216, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35859173

14.

Structure of the nutrient-sensing hub GATOR2.

Valenstein, Max L; Rogala, Kacper B; Lalgudi, Pranav V; Brignole, Edward J; Gu, Xin; Saxton, Robert A; Chantranupong, Lynne; Kolibius, Jonas; Quast, Jan-Philipp; Sabatini, David M.

Nature; 607(7919): 610-616, 2022 07.

Artículo en Inglés | MEDLINE | ID: mdl-35831510

15.

CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.

Laqtom, Nouf N; Dong, Wentao; Medoh, Uche N; Cangelosi, Andrew L; Dharamdasani, Vimisha; Chan, Sze Ham; Kunchok, Tenzin; Lewis, Caroline A; Heinze, Ivonne; Tang, Rachel; Grimm, Christian; Dang Do, An N; Porter, Forbes D; Ori, Alessandro; Sabatini, David M; Abu-Remaileh, Monther.

Nature; 609(7929): 1005-1011, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-36131016

16.

mTOR signaling in growth control and disease.

Laplante, Mathieu; Sabatini, David M.

Cell; 149(2): 274-93, 2012 Apr 13.

Artículo en Inglés | MEDLINE | ID: mdl-22500797

17.

mTOR Signaling in Growth, Metabolism, and Disease.

Saxton, Robert A; Sabatini, David M.

Cell; 169(2): 361-371, 2017 04 06.

Artículo en Inglés | MEDLINE | ID: mdl-28388417

18.

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

Bar-Peled, Liron; Schweitzer, Lawrence D; Zoncu, Roberto; Sabatini, David M.

Cell; 150(6): 1196-208, 2012 Sep 14.

Artículo en Inglés | MEDLINE | ID: mdl-22980980

19.

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.

Ersching, Jonatan; Efeyan, Alejo; Mesin, Luka; Jacobsen, Johanne T; Pasqual, Giulia; Grabiner, Brian C; Dominguez-Sola, David; Sabatini, David M; Victora, Gabriel D.

Immunity; 46(6): 1045-1058.e6, 2017 06 20.

Artículo en Inglés | MEDLINE | ID: mdl-28636954

20.

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson, Timothy R; Sengupta, Shomit S; Harris, Thurl E; Carmack, Anne E; Kang, Seong A; Balderas, Eric; Guertin, David A; Madden, Katherine L; Carpenter, Anne E; Finck, Brian N; Sabatini, David M.

Cell; 146(3): 408-20, 2011 Aug 05.

Artículo en Inglés | MEDLINE | ID: mdl-21816276

Portal de Búsqueda de la BVS España

Información y Conocimiento para la Salud

Configurar filtros

Su selección (0)

Formato de exportación:

Exportar:

Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.

Author Correction: mTOR at the nexus of nutrition, growth, ageing and disease.

mTOR at the nexus of nutrition, growth, ageing and disease.

mTOR Signaling in Growth, Metabolism, and Disease.

Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras.

Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism.

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.

Nutrient-sensing mechanisms across evolution.

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.

Structure of the nutrient-sensing hub GATOR2.

CLN3 is required for the clearance of glycerophosphodiesters from lysosomes.

mTOR signaling in growth control and disease.

mTOR Signaling in Growth, Metabolism, and Disease.

Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.