The Use of Enhanced Technologies in Robotic Surgery and Its Impact on Outcomes in Rectal Cancer: A Systematic Review.

The main advantage of the robotic approach is the surgical precision that the technology offers. It is particularly useful in rectal cancer as this is a technically challenging procedure. The technological advantage of the robot leads to better postoperative outcomes. Apart from the 3D vision and endowrist instrumentation in comparison to laparoscopy, the options of using fluorescence imaging, endowrist stapler, and table motion have revolutionised the way of performing an anterior resection. Thus, the true benefit of these advances will be the quality of the surgery, which leads to better postoperative outcomes. This article focuses on the current status of applications of new modalities and technology development in robotic rectal surgery. A systematic literature search was performed using PubMed, MEDLINE, and cochrane database. The studies included were considered based on the following (1) articles written in English, (2) full text is available, (3) whether the topic is related to the use of novel technologies during robotic rectal surgery, and (4) sample: adult patients and malignant rectal disease. The primary end point was to analyse the current use of technological advances in robotic rectal surgery. Only a few studies are currently available on the use of these different technologies in robotic colorectal surgery. Many of these reports describe promising results, although with short-term outcomes. The use of technologies in robotic colorectal surgery is safe and feasible and can be used together to improve short-term outcomes. Intraoperative fluorescence angiography has demonstrated to reduce the rate of anastomotic leak, whereas the robotic stapler and the table motion simplify anatomic resection.

Long-Term Outcomes of Robotic Versus Laparoscopic Total Mesorectal Excisions: A Propensity-Score Matched Cohort study of 5-year survival outcomes.

Objective: To compare long-term outcomes between laparoscopic and robotic total mesorectal excisions (TMEs) for rectal cancer in a tertiary center. Background: Laparoscopic rectal cancer surgery has comparable long-term outcomes to the open approach, with several advantages in short-term outcomes. However, it has significant technical limitations, which the robotic approach aims to overcome. Methods: We included patients undergoing laparoscopic and robotic TME surgery between 2013 and 2021. The groups were compared after propensity-score matching. The primary outcome was 5-year overall survival (OS). Secondary outcomes were local recurrence (LR), distant recurrence (DR), disease-free survival (DFS), and short-term surgical and patient-related outcomes. Results: A total of 594 patients were included, and after propensity-score matching 215 patients remained in each group. There was a significant difference in 5-year OS (72.4% for laparoscopy vs 81.7% for robotic, P = 0.029), but no difference in 5-year LR (4.7% vs 5.2%, P = 0.850), DR (16.9% vs 13.5%, P = 0.390), or DFS (63.9% vs 74.4%, P = 0.086). The robotic group had significantly less conversion (3.7% vs 0.5%, P = 0.046), shorter length of stay [7.0 (6.0-13.0) vs 6.0 (4.0-8.0), P < 0.001), and less postoperative complications (63.5% vs 50.7%, P = 0.010). Conclusions: This study shows a correlation between higher 5-year OS and comparable long-term oncological outcomes for robotic TME surgery compared to the laparoscopic approach. Furthermore, lower conversion rates, a shorter length of stay, and a less minor postoperative complications were observed. Robotic rectal cancer surgery is a safe and favorable alternative to the traditional approaches.

The use of robotic or laparoscopic stapler in rectal cancer surgery: a systematic review and meta-analysis.

Minimally invasive surgery for total mesorectal excision (TME) remains technically challenging due to poor maneuverability within the pelvis, which makes extremely difficult to introduce a laparoscopic stapler (LS) for the rectal transection. We aim to perform a systematic review and meta-analysis on robotic TME after the use of robotic stapler (RS) or LS after robotic TME. A systematic literature search was performed using PubMed, MEDLINE, and Cochrane Database. Participants who underwent robotic anterior resection were considered following these criteria: (1) studies comparing RS and LS; (2) studies reporting the rate of anastomotic leakage (AL). The primary outcome was the risk of AL. Secondary outcomes included the number of firings of stapler needed. A meta-analysis based on Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement was performed. A total of 4 studies including 391 patients (LS = 251, RS = 140) were included for analysis. Regarding the number of firings, overall results suggest that the rectal stapling was achieved with less firings in the RS group, but the difference is not significant [risk difference, (95% CI) 0.42 (- 0.13, 0.97)]. There was a 56% increased odds of AL for LS compared with RS; however, this was not statistically significant (OR: 1.56; 95% CI 0.59, 4.14). With the current literature evidence, the present study could not demonstrate a clear benefit of the RS over the LS. Although the development of an AL is multifactorial and unpredictable, our data may suggest that the use of the RS could help reducing the risk of AL. There is a need of future randomized clinical trial to assess the possible benefits of the RS.

Laparoscopic versus open left lateral segmentectomy.

BACKGROUND: Laparoscopic liver surgery is becoming increasingly common. This cohort study was designed to directly compare perioperative outcomes of the left lateral segmentectomy via laparoscopic and open approach. METHODS: Between 2002 and 2006 43 left lateral segmentectomies were performed at King's College Hospital. Those excluded from analysis included previous liver resections, polycystic liver disease, liver cirrhosis and synchronous operations. Of 20 patients analysed, laparoscopic (n = 10) were compared with open left lateral segmentectomy (n = 10). Both groups had similar patient characteristics. RESULTS: Morbidity rates were similar with no wound or chest infection in either group. The conversion rate was 10% (1/10). There was no difference in operating time between the groups (median time 220 minutes versus 179 minutes, p = 0.315). Surgical margins for all lesions were clear. Less postoperative opiate analgesics were required in the laparoscopic group (median 2 days versus 5 days, p = 0.005). The median postoperative in-hospital stay was less in the laparoscopic group (6 days vs 9 days, p = 0.005). There was no mortality. CONCLUSION: Laparoscopic left lateral segmentectomy is safe and feasible. Laparoscopic patients may benefit from requiring less postoperative opiate analgesia and a shorter post-operative in-hospital stay.

A rare metastases of a colorectal primary to the clavicle.

INTRODUCTION: Colorectal cancer is the third commonest cancer in the UK. The commonest site of colorectal cancer metastases is the liver, followed by lungs. Metastases to small bones are recognized but are a rare occurrence of colorectal malignancy. PRESENTATION OF CASE: A 92 year old lady presented with a swollen, fractured right clavicle following a fall. On follow up, a swelling of approximately 10cm was still noted in the area. A CT scan revealed a ten by ten centimetres mass arising from the clavicle and a 9cm mass arising from the left aspect of the sacrum. She was also found to have complete collapse of the left lung with an underlying mass and a mass within the right lung. Biopsy of the clavicular mass was suggestive of metastatic colorectal adenocarcinoma. She had undergone an anterior resection for Dukes C adenocarcinoma six years previously. DISCUSSION: This case demonstrates the rare metastases of a colorectal primary to the clavicle, a clavicle metastases of this size has not been previously reported in literature. CONCLUSION: A high index of suspicion for potential of small bone metastases has to be entertained in a patient presenting with a non-healing fracture and a history of colorectal carcinoma.

N-acetylcysteine improves the viability of human hepatocytes isolated from severely steatotic donor liver tissue.

Hepatocyte transplantation is dependent on the availability of good quality human hepatocytes isolated from donor liver tissue. Hepatocytes obtained from livers rejected for transplantation on the grounds of steatosis are often of low viability and not suitable for clinical use. The aim of this study was to evaluate the effects of the antioxidant N-acetylcysteine (NAC) on the function of hepatocytes isolated from steatotic donor livers. Human hepatocytes were isolated from 10 severely steatotic (>60%) donor livers rejected for transplantation. The left lateral segment of the donor liver was dissected into two equal size pieces and randomized to NAC or control. NAC (5 mM) was added to the first perfusion buffer of the standard collagenase digestion technique. Cells from tissues perfused with NAC had a significantly higher mean viability (81.1 ± 1.7% vs. 66.0 ± 4.7%; p = 0.003) and cell attachment (1.08 ± 0.26 vs. 0.67 ± 0.18 OD units; p = 0.012). Addition of NAC during isolation of human hepatocytes from steatotic donor liver tissue significantly improved the outcome of cell isolation. Further studies are needed to investigate the mechanism(s) of this effect. Incorporation of NAC in the hepatocyte isolation protocol could increase the availability of hepatocytes for transplantation.