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1.
Turk J Med Sci ; 49(2): 472-477, 2019 04 18.
Artículo en Inglés | MEDLINE | ID: mdl-30887796

RESUMEN

Background/aim: The distribution of Mediterranean fever (MEFV) gene mutations in Turkish familial Mediterranean fever (FMF) patients varies according to geographic area of Turkey. There is a need for highly representative data for Turkish FMF patients. The aim of our study was to investigate the distribution of the common MEFV mutations in Turkish FMF patients in a nationwide, multicenter study. Materials and methods: Data of the 2246 FMF patients, from 15 adult rheumatology clinics located in different parts of the country, were evaluated retrospectively. The following mutations have been tested in all patients: M694V, M680I, M694I, V726A, and E148Q. Results: There were 1719 FMF patients with available genetic testing. According to the genotyping, homozygous M694V, present in 413 patients (24%), was the most common mutation . One hundred and fifty-four (9%) of patients had no detectable mutations. Allele frequencies of common mutations were: M694V (n = 1529, 44.5%), M680I (n = 423, 12.3%), V726A (n = 315, 9.2%), E148Q (n = 214, 1%), and M694I (n = 12, <1%). Conclusion: In this large-scale multicenter study, we provided information about the frequencies of common MEFV gene mutations obtained from adult Turkish FMF patients. Nearly half of the patients were carrying at least one M694V mutations in their alleles.


Asunto(s)
Proteínas del Citoesqueleto/genética , Fiebre Mediterránea Familiar/genética , Genética de Población , Mutación/genética , Pirina/genética , Adolescente , Adulto , Niño , Análisis Mutacional de ADN , Fiebre Mediterránea Familiar/diagnóstico , Femenino , Frecuencia de los Genes , Predisposición Genética a la Enfermedad/epidemiología , Pruebas Genéticas , Genética de Población/estadística & datos numéricos , Humanos , Masculino , Persona de Mediana Edad , Tasa de Mutación , Estudios Retrospectivos , Turquía/epidemiología , Adulto Joven
2.
Rheumatology (Oxford) ; 53(4): 741-5, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-24369413

RESUMEN

OBJECTIVE: The primary aim of this study was to investigate the prevalence of amyloidosis and its related factors in a large number of FMF patients. METHODS: Fifteen centres from the different geographical regions of Turkey were included in the study. Detailed demographic and medical data based on a structured questionnaire and medical records were collected. The diagnosis of amyloidosis was based on histological proof of congophilic fibrillar deposits in tissue biopsy specimens. RESULTS: There were 2246 FMF patients. The male/female ratio was 0.87 (1049/1197). The mean age of the patients was 34.5 years (S.D. 11.9). Peritonitis was the most frequent clinical finding and it was present in 94.6% of patients. Genetic testing was available in 1719 patients (76.5%). The most frequently observed genotype was homozygous M694V mutation, which was present in 413 (24%) patients. Amyloidosis was present in 193 patients (8.6%). Male sex, arthritis, delay in diagnosis, M694V genotype, patients with end-stage renal disease (ESRD) and family history of amyloidosis and ESRD were significantly more prevalent in patients with amyloidosis compared with the amyloidosis-negative subjects. Patients with homozygous M694V mutations had a 6-fold higher risk of amyloidosis compared with the other genotypes (95% CI 4.29, 8.7, P < 0.001). CONCLUSION: In this nationwide study we found that 8.6% of our FMF patients had amyloidosis and homozygosity for M694V was the most common mutation in these patients. The latter finding confirms the association of homozygous M694V mutation with amyloidosis in Turkish FMF patients.


Asunto(s)
Amiloidosis/etiología , Fiebre Mediterránea Familiar/complicaciones , Adulto , Amiloidosis/genética , Artritis/etiología , Proteínas del Citoesqueleto/genética , Diagnóstico Tardío , Fiebre Mediterránea Familiar/genética , Femenino , Genotipo , Homocigoto , Humanos , Fallo Renal Crónico/etiología , Masculino , Persona de Mediana Edad , Pirina , Estudios Retrospectivos , Factores de Riesgo , Factores Sexuales , Turquía , Adulto Joven
3.
Ginekol Pol ; 85(11): 815-22, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25675797

RESUMEN

OBJECTIVE: The aim of the study was to evaluate the safety and efficacy of early feeding after cesarean delivery under different anesthetic methods. STUDY DESIGN: Two hundred women with elective cesarean delivery were randomly assigned to early oral feeding (EOF) or routine oral feeding (ROF) groups. EOF patients were informed that they could begin taking fluids orally (regime I) as soon as 2 hours after the delivery and then gradually progress to solid foods (regime III), if tolerated. ROF patients were informed that they could start regime I right after bowel sounds were heard on examination and then gradually move on to regime III. Hospitalization time and total time to ambulation (primary outcomes), gasstool discharge time and onset of bowel sounds (secondary outcomes) were compared in groups A [EOF patients after regional anesthesia (n=49)}, B [EOF patients after general anesthesia (n=48)}, C [ROF patients after regional anesthesia (n=47)} and 0 [ROF patients after general anesthesia (n=48)]. RESULTS: There were significant differences in primary and secondary outcomes between group A and the remaining groups, especially group D. The status of patients from group B was not better than group C. In fact, the latter were discharged home sooner and passage of gas, as well as initiation of regime I occurred earlier as compared to the former CONCLUSIONS: Cesarean section under regional anesthesia and encouragement of oral feeding 2 hours after the operation should be recommended in order to acnieve postoperative recovery and early hospital discharge. Routine oral feeding (right after bowel sounds are heard on examination) after cesarean section under general anesthesia should be the last choice.


Asunto(s)
Anestesia de Conducción/estadística & datos numéricos , Anestesia General/estadística & datos numéricos , Cesárea/rehabilitación , Ambulación Precoz/métodos , Métodos de Alimentación , Motilidad Gastrointestinal/fisiología , Cuidados Posoperatorios , Adulto , Femenino , Humanos , Embarazo , Estudios Prospectivos , Medición de Riesgo , Factores de Tiempo
4.
J Assist Reprod Genet ; 30(6): 765-72, 2013 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-23666546

RESUMEN

PURPOSE: To examine the relationship between serum total oxidant (TOS) and antioxidant (TAS) levels and clinical pregnancy in assisted reproductive technology (ART) cycles. METHODS: Prior to and after oocyte pick-up (OPU) and embryo transfer (ET), blood samples were collected from gynecologically normal females (n = 70) who were enrolled for ART solely due to male factor infertility. TAS, TOS levels and oxidative stress indexes (OSI: TOS/TAS) in four phases of treatment cycle (pre and post OPU and ET) between clinically pregnant and non-pregnant patients were compared. Critical cut-off values of significantly different TAS, TOS levels and OSIes for clinical pregnancy were established. RESULTS: The TAS levels in patients with clinical pregnancy were significantly higher in all of the four phases of the cycle. Post-OPU and pre-ET TOS levels were significantly higher in clinically pregnant patients. According to OSIes; only the pre-OPU OSI was significantly lower in clinically pregnant patients compared with non-pregnant ones. Moreover, the highest area under the ROC curve (AUC) from the seven different significant measurements [1) pre-OPU OSI, 2) pre-OPU TAS, 3) post-OPU TAS, 4) pre-ET TAS, 5) post-ET TAS, 6) post-OPU TOS, 7) pre-ET TOS] was related to pre-OPU OSI. CONCLUSIONS: In ART cycles, women with a higher total antioxidant status prior to and after OPU and prior to and after ET have an increased probability of clinical pregnancy. Additionally; OSI before OPU was one of the most important determinants for clinical pregnancy, so the oxidant and antioxidant balance is as important as the antioxidant concentration alone.


Asunto(s)
Antioxidantes/metabolismo , Oxidantes/sangre , Estrés Oxidativo , Técnicas Reproductivas Asistidas , Adulto , Femenino , Humanos , Masculino , Embarazo , Curva ROC
5.
Rheumatol Int ; 32(1): 259-62, 2012 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-21240498

RESUMEN

This study was conducted in Turkish osteoarthritis patients to determine the frequency of 4G/5G polymorphism genotypes of plasminogen activator inhibitor type-1 gene and to examine the role of this polymorphism in osteoarthritis development. Genomic DNA obtained from 200 persons (140 patients with osteoarthritis and 60 healthy controls) was used in the study. DNA was amplified by polymerase chain reaction using 4G allele- and 5G allele-specific primers. Polymerase chain reaction products were assessed with CCD camera by being exposed to 2% agarose gel electrophoresis. No statistically significant difference between the groups with respect to genotype distribution was found (P > 0.05) in the study. The 4G allele frequency was indicated as 44% and 5G allele was as 56% in patients, whereas this was 45-55% in the control group. This study has established that 4G/5G polymorphism genotypes of plasminogen activator inhibitor type-1 gene do not play a role in the development of osteoarthritis in the Turkish population.


Asunto(s)
Osteoartritis/genética , Inhibidor 1 de Activador Plasminogénico/genética , Polimorfismo Genético/genética , Adulto , Estudios de Casos y Controles , Femenino , Frecuencia de los Genes/genética , Genotipo , Humanos , Masculino , Persona de Mediana Edad , Osteoartritis/etnología , Turquía
6.
Mol Biol Rep ; 38(4): 2463-9, 2011 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-21104029

RESUMEN

Natural compounds such as resveratrol, tannic acid, and quercetin may help to treat cancer. Tamoxifen is a non-steroidal anti-estrogen drug widely used in the treatment of patients with estrogen receptor-positive breast cancer. The aim of the study was to compare the effects of these natural compounds and tamoxifen in colon adenocarcinoma (CaCo-2) and breast adenocarcinoma (MCF-7) cell lines, on telomerase enzyme activity, cell viability, number of cells and DNA fragmentation. In this study to determine telomerase enzyme activity was used PCR-ELISA kit. To determine cell viability and number of cells were used tripan blue stain. DNA fragmentation was determined by DNA ladder isolation kit. Tannic acid was more effective than resveratrol, with respect to reduction in telomerase activity, cell viability and cell count in breast adenocarcinoma. Tannic acid and tamoxifen was more effective than resveratrol and quercetin telomerase activity, cell viability and cell count in colon adenocarcinoma. Flavonoids such as resveratrol, tannic acid and quercetin which was studied on, has benefical effects on cancer therapy. These effects such as decreasing telomerase enzyme activity, cell viability and number of cells and inducing DNA fragmentation (apoptosis) must be studied for assist to develop new therapeutic pathways. There should be much more sudies in order to discover resveratrol, tannic acid and quercetin and other potential medicines.


Asunto(s)
Adenocarcinoma/metabolismo , Fragmentación del ADN/efectos de los fármacos , Telomerasa/metabolismo , Análisis de Varianza , Línea Celular Tumoral , Ensayo de Inmunoadsorción Enzimática , Humanos , Quercetina/farmacología , Resveratrol , Estilbenos/farmacología , Tamoxifeno/farmacología , Taninos/farmacología
7.
Turk Psikiyatri Derg ; 32(3): 160-166, 2021.
Artículo en Inglés, Turco | MEDLINE | ID: mdl-34647286

RESUMEN

OBJECTIVE: In this study, we aimed to investigate the Neurexin 3 gene (NRXN3) polymorphisms in the rs 221473, rs 221497, rs1004212 and rs11624704 regions in relation to nicotine use disorder (NUD) in the Turkish population. METHOD: Power analysis indicated that the NUD group and the control group of this study should each comprise 200 participants in the 18-65 year age range. The NUD group consisted of individuals without a psychiatric first axis disorder except for NUD, mental retardation, past head trauma or a neurological disorder, who had smoked minimally10 cigarettes per day for at least 1 year. The control group included individuals without a serious chronic physical illness, a previous psychiatric disorder or mental retardation and who responded "no" to the question "have you ever smoked?" A sociodemographic questionnaire and the Fageström nicotine dependence scale (FNDS) for the NUD group were utilized. Venous blood samples of all participants were taken into tubes containing EDTA (ethylene daimine tetra acetic acid) for DNA extraction. Duplex fluorescence melting curve analysis was used for genotype detection and differentiation. RESULTS: The individuals carrying the AC allele and the AG allele at the rs11624704 and the rs1004212 regions respectively had a high risk of being addicted to cigarettes. CONCLUSION: This is first study investigating the relationship of the NRXN3 gene and nicotine addiction in the Turkish population. It was observed that the risk of NUD in the Turkish population may be related to the Neurexin gene.


Asunto(s)
Tabaquismo , Genotipo , Humanos , Polimorfismo Genético , Tabaquismo/genética
8.
Turk Psikiyatri Derg ; 32(3): 160-166, 2021.
Artículo en Inglés, Turco | MEDLINE | ID: mdl-34750790

RESUMEN

OBJECTIVE: In this study, we aimed to investigate the Neurexin 3 gene (NRXN3) polymorphisms in the rs 221473, rs 221497, rs1004212 and rs11624704 regions in relation to nicotine use disorder (NUD) in the Turkish population. METHOD: Power analysis indicated that the NUD group and the control group of this study should each comprise 200 participants in the 18-65 year age range. The NUD group consisted of individuals without a psychiatric first axis disorder except for NUD, mental retardation, past head trauma or a neurological disorder, who had smoked minimally10 cigarettes per day for at least 1 year. The control group included individuals without a serious chronic physical illness, a previous psychiatric disorder or mental retardation and who responded "no" to the question "have you ever smoked?" A sociodemographic questionnaire and the Fageström nicotine dependence scale (FNDS) for the NUD group were utilized. Venous blood samples of all participants were taken into tubes containing EDTA (ethylene daimine tetra acetic acid) for DNA extraction. Duplex fluorescence melting curve analysis was used for genotype detection and differentiation. RESULTS: The individuals carrying the AC allele and the AG allele at the rs11624704 and the rs1004212 regions respectively had a high risk of being addicted to cigarettes. CONCLUSION: This is first study investigating the relationship of the NRXN3 gene and nicotine addiction in the Turkish population. It was observed that the risk of NUD in the Turkish population may be related to the Neurexin gene.


Asunto(s)
Proteínas del Tejido Nervioso/genética , Tabaquismo , Humanos , Polimorfismo Genético , Fumar , Tabaquismo/genética , Turquía
9.
Acta Neurochir (Wien) ; 151(9): 1135-41, 2009 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-19436949

RESUMEN

BACKGROUND: Vasospasm is a significant reason for poor clinical outcome in subarachnoid haemorrhage (SAH). One of the possible causes of vasospasm is attributed to the inhibition of Na(+)/K(+)-ATPase and increased intracellular calcium. Although digoxin, a cardiac glycoside (CG), inhibits the Na(+)/K(+)-ATPase, diverse and contradictory biological actions of CGs have also been reported. This study aimed to investigate the effect of digoxin on an experimental vasospasm after subarachnoid haemorrhage (SAH) in rats. METHODS: The rats used in the study were divided into normal, saline, SAH, and drug groups. A double-haemorrhage method was applied for the SAH groups. Normal saline or blood samples were injected into the cisterna magna. No surgical procedures were performed on the normal group. For the drug groups, daily digoxin was administered intraperitoneally after saline or blood injections. On days 3 and 7 after injections, the brains and basilar artery sections of all the groups were prepared for light-microscopic examination. The wall thickness and luminal area of the basilar artery were calculated by using medical imaging software. RESULTS: Increased wall thickness and reduced vessel luminal area were conspicuously significant in the SAH groups which did not receive digoxin. In SAH groups after digoxin administration, the vessel wall thickness decreased, and no significant change was found in vessel wall thickness when compared with the normal and saline groups. The vessel luminal area was not reduced in SAH after digoxin administration. CONCLUSIONS: These results suggest that digoxin administration in experimental SAH may have a beneficial effect on the protection against vasospasm. If further investigations support our results, the present study may offer a new insight into the treatment of SAH.


Asunto(s)
Digoxina/uso terapéutico , Inhibidores Enzimáticos/uso terapéutico , Hemorragia Subaracnoidea/complicaciones , Vasoespasmo Intracraneal/prevención & control , Animales , Arteria Basilar/efectos de los fármacos , Arteria Basilar/patología , Modelos Animales de Enfermedad , Hipertrofia/tratamiento farmacológico , Hipertrofia/fisiopatología , Hipertrofia/prevención & control , Músculo Liso Vascular/efectos de los fármacos , Músculo Liso Vascular/fisiopatología , Ratas , Ratas Sprague-Dawley , ATPasa Intercambiadora de Sodio-Potasio/antagonistas & inhibidores , ATPasa Intercambiadora de Sodio-Potasio/metabolismo , Resultado del Tratamiento , Vasoespasmo Intracraneal/patología , Vasoespasmo Intracraneal/fisiopatología
10.
Turk J Ophthalmol ; 49(2): 61-67, 2019 Apr 30.
Artículo en Inglés | MEDLINE | ID: mdl-31055889

RESUMEN

Objectives: To investigate the role of oxidative stress on pseudoexfoliation formation and progression from pseudoexfoliation syndrome (XFS) to pseudoexfoliation glaucoma (XFG). Materials and Methods: This study investigated oxidative stress biomarkers in blood samples from 58 patients with XFG, 47 patients with XFS, and 134 healthy age- and sex-matched controls. Results: The highest serum malondialdehyde (MDA) levels were measured in XFG patients (p<0.001), and MDA level was higher in XFS patients than controls (p<0.001). Superoxide dismutase (SOD) and catalase (CAT) enzyme activities were significantly lower in XFS and XFG patients than in the control group, whereas a significant increase was observed in glutathione (GSH) levels (p<0.001 for all). However, levels of these three biomarkers did not differ significantly between XFS and XFG patients (p=0.188, p=0.185, and p=0.733, respectively). Nitric oxide (NO) concentration was significantly lower in XFG patients compared to XFS patients and controls (p<0.001) but did not differ between XFS patients and controls (p=0.476). Conclusion: Elevated MDA levels suggest that lipid peroxidation is important in XFS and XFG development and progression from XFS to XFG. In addition, reduction in SOD and CAT enzyme activities is considered a deficiency in the enzymatic antioxidant protection system. Furthermore, GSH values may be evaluated as a compensatory response to oxidative stress in XFS and XFG. Alterations in NO indicate the role of a vascular regulatory factor in the progression from XFS to glaucoma.

11.
Eur J Rheumatol ; 6(1): 34-37, 2019 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-30489254

RESUMEN

OBJECTIVE: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease. Most of the identified disease-causing mutations are located on exon 10. As the number of studies about the effect of the exonal location of the mutation and its phenotypic expression is limited, we aimed to investigate whether the exonic location of the Mediterranean fever (MEFV) mutation has an effect on the clinical manifestation in patients with FMF. METHODS: Study population was derived from the main FMF registry that included 2246 patients from 15 different rheumatology clinics. We categorized the mutations according to their exon locations and retrieved the clinical and demographic information from the database. RESULTS: Patients having the MEFV mutations on exon 2 or 10 (n:1526) were divided into three subgroups according to the location of the MEFV mutations: Group 1 (exon 2 mutations), Group 2 (exon 10 mutations), and Group 3 (both exon 2 and exon 10 mutations). Group 2 patients were of a significantly younger age at onset, and erysipel-like erythema, arthritis, amyloidosis, and a family history of FMF were more common in this group. CONCLUSION: Patients with FMF and exon 10 mutations show more severe clinical symptoms and outcome. Exon 2 mutations tend to have a better outcome.

12.
Turk Psikiyatri Derg ; 29(3): 154-161, 2018.
Artículo en Turco | MEDLINE | ID: mdl-30260461

RESUMEN

OBJECTIVE: In this study, we aimed to investigate the effect of chronic cigarette smoking on the cognitive function in people who have no other mental or physical illness other than tobacco use disorder. METHOD: The study was carried out on three groups: smokers (n = 71), former smokers (n = 39), and non-smokers (n = 49). The Wisconsin Card Sorting Test (WCST), Stroop Color and Word Test (ST), Trail Making Test (TMT), Auditory Verbal Learning Test (AVLT), and Serial Digit Learning Test (SDLT) were applied to the 3 groups participating in the study. Groups were compared with the Three-Factor Covariance Analysis. RESULTS: Stroop test 4th card time score which determined the basic level of color discourse in the smoker group was significantly higher than the non-smoker group. The Trail Making Test-B time scores were significantly higher in the smoker group than the non-smoker group. And Trail Making Test-B time points were significantly higher in the former smoker group than nonsmoker group. Auditory Verbal Learning Test - verbal learning scores were lower in the smoker group than the non-smoker and former smoker group. There was no significant difference in verbal learning scores between the non-smoking and former smoker groups. The neurocognitive deficits in smokers appear to be related to dose and duration. CONCLUSION: This study suggests that auditory verbal memory, visualspatial processing, and attention areas may be a selective area of disability in smokers. A major limitation is the fact that general cognitive performance levels of participants was not assessed by a general criteria such as Wechsler Adult Intelligence Scale (WAIS).


Asunto(s)
Trastornos del Conocimiento/inducido químicamente , Cognición , Fumar/efectos adversos , Adulto , Femenino , Humanos , Masculino , Pruebas Neuropsicológicas
13.
Int J Rheum Dis ; 21(4): 880-884, 2018 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-29314707

RESUMEN

AIM: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease. One of the common characteristics of this disease is its young age predominance. Nearly 90% of patients experience disease flares during early adult age periods. Currently there are limited data for the comparison of early versus late onset FMF and therefore the primary aim of this study was to investigate these two subsets with regard to their certain demographic, clinical and genetic differences. METHODS: Early (≤ 20 years, Group 1) and late (> 20 years, Group 2) onset FMF patients were identified from the national FMF registry that involves 2246 patients from 15 adult rheumatology clinics located in different geographical areas of Turkey. RESULTS: Of the 2246 patients, 1633 (72.7%) were aged ≤ 20 years old (Group 1) and the remaining 613 were older than 20 years (Group 2). Delay in diagnosis was longer in Group 1 and fever, peritonitis, pleuritis, erysipelas-like erythema (ELE), arthritis, family history of FMF and amyloidosis were more common in Group 1. On the other hand, sex distribution, rates of amyloidosis, vasculitis and kidney failure were not different between the groups. Among patients with available genotypes, homozygous and heterozygous M694V mutations were significantly higher and heterozygous E148Q mutation was significantly lower in Group 1 compared to Group 2. CONCLUSION: Patients with FMF whose symptoms start before 20 years of age seem to have severe symptoms and M694V mutation may be responsible for the early expression of the disease.


Asunto(s)
Fiebre Mediterránea Familiar/genética , Mutación , Pirina/genética , Adolescente , Adulto , Edad de Inicio , Niño , Diagnóstico Tardío , Progresión de la Enfermedad , Fiebre Mediterránea Familiar/diagnóstico , Fiebre Mediterránea Familiar/epidemiología , Femenino , Predisposición Genética a la Enfermedad , Humanos , Masculino , Tasa de Mutación , Fenotipo , Valor Predictivo de las Pruebas , Sistema de Registros , Estudios Retrospectivos , Factores de Riesgo , Índice de Severidad de la Enfermedad , Distribución por Sexo , Factores de Tiempo , Turquía/epidemiología , Adulto Joven
14.
Int J Rheum Dis ; 19(7): 665-71, 2016 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-26222244

RESUMEN

AIM: Insulin resistance (IR) plays an important role in the development of cardiovascular events in rheumatoid arthritis (RA) patients. Adiponectin influences insulin sensitivity but its impact on IR in RA patients remains unclear. The present study aims to investigate the role of methotrexate (MTX) and low doses of prednisolone (LDP) on IR and adiponectin levels in RA patients who are naïve to disease-modifying antirheumatic drugs (DMARDs), as well as determining the relationship between disease activity, acute phase response, IR and adiponectin levels in patients with RA. METHODS: Sixty-five RA patients naïve to DMARDs and prednisolone were involved in this study. The medication for RA patients was standardized for MTX and prednisolone. Body mass index, acute phase response reactants, 28-joint-count disease activity score, fasting blood glucose, serum cholesterol levels, insulin levels and adiponectin levels were measured in all RA patients both at the baseline and 3 months after the onset of the study. RESULTS: Adiponectin levels in the third month of the therapy with MTX and LDP were significantly increased in patients with RA (P = 0.03). Insulin resistance tended to decrease in the third month of the treatment, which achieved no statistical significance. CONCLUSION: Increased levels of adiponectin due to MTX and LDP could be related to the decrease in homeostasis model assessment insulin resistance (HOMA-IR) in RA patients. This, in turn, could prove advantageous for cardiovascular conditions in RA.


Asunto(s)
Adiponectina/sangre , Antirreumáticos/uso terapéutico , Artritis Reumatoide/tratamiento farmacológico , Resistencia a la Insulina , Metotrexato/administración & dosificación , Prednisolona/administración & dosificación , Adulto , Anciano , Antirreumáticos/efectos adversos , Artritis Reumatoide/sangre , Artritis Reumatoide/diagnóstico , Artritis Reumatoide/fisiopatología , Biomarcadores/sangre , Glucemia/efectos de los fármacos , Glucemia/metabolismo , Quimioterapia Combinada , Femenino , Humanos , Insulina/sangre , Masculino , Metotrexato/efectos adversos , Persona de Mediana Edad , Prednisolona/efectos adversos , Factores de Tiempo , Resultado del Tratamiento , Regulación hacia Arriba
15.
Turk J Haematol ; 22(2): 71-8, 2005 Jun 05.
Artículo en Inglés | MEDLINE | ID: mdl-27264664

RESUMEN

The commonest cause of iron deficiency anemia (IDA) in premenopausal women is often menstrual blood loss. However, no organic pathology is identified in more than 50% of menorrhagic women. We therefore investigated inherited and acquired bleeding disorders among women with unexplained menorrhagia who developed IDA. In vitro whole blood platelet aggregation (PA) with ADP, arachidonic acid (AA), ristocetin and collagen was studied in addition to full blood count, serum iron levels, serum iron binding capacity, transferrin saturation, ferritin, prothrombin and activated partial thromboplastin time, fibrinogen, D-Dimer, Factor VIII, Factor IX, Factor XI, ristocetin cofactor activity, blood type and bleeding time in 67 women before and after therapy. Before therapy; decreased agonist induced PA was observed in 20% of women by ADP, in 12% by AA, in 2% by ristocetin and in 6% by collagen. After oral iron therapy, decreased platelet aggregation was shown in 8% of women with ADP and 2% of women with AA while initial abnormal ristocetin and collagen induced platelet aggregation responses became normal. Also there was a statistically significant increase of ristocetin cofactor activities and FXI levels after iron repletion. We conclude that; rather than von Willebrand disease, platelet function abnormalities and FXI deficiency are the most common hemostatic disorders in women with unexplained menorrhagia and significant portion of these disorders can be reversed by iron therapy.

16.
Int Forum Allergy Rhinol ; 5(2): 132-42, 2015 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-25424754

RESUMEN

BACKGROUND: Although the effectiveness of allergen monotherapy immunotherapy for allergic rhinitis (AR) has been well established by many prior studies, other aspects of immunotherapy are still incompletely documented by high-quality studies. The many published papers describe various results. The aim of the present study was to conduct a meta-analysis on the effectiveness of allergen immunotherapy. METHODS: A total of 56 homogeneous studies were included in the analysis. The inclusion criteria used to select articles were as follows: (1) placebo-controlled clinical trials; (2) the use of immunotherapy; (3) participants and/or physicians were or were not blinded to immunotherapy or placebo assignment (single-blinding, double-blinding, or no-blinding studies); and (4) randomization or not of those in the immunotherapy and placebo groups. RESULTS: Between 2003 and 2013, 114 placebo-controlled clinical trials were reported in Medline. Studies describing recovery rates in immunotherapy and placebo groups numbered 56. The distribution of such works was homogeneous (heterogeneity chi-square = 16.11; degrees of freedom [df] = 55; p = 1.000). The extent of recovery in immunotherapy groups was 53.671-fold greater than in placebo groups (Mantel-Haenszel [M-H] pooled risk ratio [RR] = 53.671; 95% confidence interval [CI], 36.981 to 77.893; z = 20.96; p < 0.001). CONCLUSION: Our meta-analysis suggests that immunotherapy is associated with a recovery rate 53.671-fold that of placebo.


Asunto(s)
Desensibilización Inmunológica/métodos , Rinitis Alérgica/terapia , Ensayos Clínicos Controlados como Asunto , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto , Resultado del Tratamiento
17.
Hypertens Res ; 38(9): 621-6, 2015 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-25971629

RESUMEN

A significant correlation between hypertension history and high blood pressure has been observed with regard to age, race and gender. Investigating carotid intima-media thickness and aortic stiffness prior to the development of hypertension in children of hypertensive parents enabled us to evaluate these patients for subclinical atherosclerosis. We compared carotid intima-media thickness, aortic strain, distensibility, stiffness indices and elastic modulus in 67 normotensive children whose parents had a diagnosis of essential hypertension and 39 normotensive children with no parental history of hypertension. Although there were no significant differences between the two groups in terms of systolic blood pressure, diastolic blood pressure, average blood pressure and pulse pressure (P>0.05), systolic blood pressures were higher among patients 15 years and older in the study group. No significant differences were noted between the control and study groups regarding interventricular septal thickness, left-ventricular posterior wall thickness, left-ventricular systolic and diastolic diameter and aortic annulus diameter (P>0.05). The left atrium diameter was larger in the study group compared with that in the control group, mainly because of the values of the 15-year-old and older children (P=0.01). The mean, maximum and minimum values of carotid intima-media thickness were significantly different in the study group compared with the control group among all age groups (P<0.001, P<0.001, P=0.006, respectively). Aortic systolic and diastolic diameters were larger in normotensive children of hypertensive parents compared with the control group (P=0.014, P=0.001, respectively). Although there were no differences between the study and control groups regarding aortic strain, aortic distensibility, elastic modulus and stiffness indices (P>0.05), aortic distensibility was lower, and aortic stiffness indices were higher among children 15 years and older in the study group. An increase in the carotid intima-media thickness in all age groups and a decrease in aortic elastic properties in 15-year-old and older children of hypertensive parents may indicate subclinical atherosclerosis in these apparently healthy children.


Asunto(s)
Aorta/fisiopatología , Grosor Intima-Media Carotídeo , Hipertensión/fisiopatología , Rigidez Vascular/genética , Adolescente , Adulto , Envejecimiento , Función del Atrio Izquierdo , Niño , Ecocardiografía , Elasticidad , Femenino , Humanos , Hipertensión/genética , Masculino , Padres , Función Ventricular Izquierda
18.
Hepatogastroenterology ; 51(58): 994-7, 2004.
Artículo en Inglés | MEDLINE | ID: mdl-15239232

RESUMEN

BACKGROUND/AIMS: Anastomotic leaks are continuing to be the source of major morbidity in colorectal surgery. Previous studies have shown that leptin acts as a growth factor for several cell types. The aim of this study was to evaluate the effect of leptin on healing of colonic anastomoses in rats. METHODOLOGY: Forty-eight rats were divided into 5 groups. Group I (n=8) sham; group II (n=10) control; right colonic anastomosis, group III (n=10); following right colonic anastomosis, treated with leptin twice-daily 1 mg/kg intraperitoneally, group IV (n=10); before right colonic anastomosis, 45 min of colonic ischemia has been created, group V (n=10); following 45 min of colonic ischemia and right colonic anastomosis, leptin was given twice-daily 1 mg/kg intraperitoneally. On the 7th postoperative day relaparotomy was performed. Bursting pressure (BP), tissue hydroxyproline concentrations (THPC), and histopathologic properties of anastomoses; vascular tissue proliferation (VTP), collagen tissue proliferation (CTP), polymorphonuclear leukocyte infiltration (PMNLI), mononuclear leukocyte infiltration (MNLI) were analyzed and results were compared statistically. RESULTS: BP and THPC were found to be significantly higher in group III and group V in comparison with group II and group IV respectively (P<0.05). Histopathologically, leptin significantly increased VTP, CTP, MNLI (P<0.001), and significantly decreased PMNLI (p<0.05) on non-ischemic and ischemic colonic anastomoses. CONCLUSIONS: Leptin can be used safely in colorectal surgery since it accelerates the healing of colonic anastomoses.


Asunto(s)
Anastomosis Quirúrgica , Colon/fisiopatología , Colon/cirugía , Leptina/farmacología , Cicatrización de Heridas/efectos de los fármacos , Animales , Vasos Sanguíneos/patología , División Celular , Colágeno/metabolismo , Colon/irrigación sanguínea , Colon/metabolismo , Colon/patología , Hidroxiprolina/metabolismo , Isquemia/fisiopatología , Masculino , Infiltración Neutrófila , Ratas , Ratas Wistar , Resistencia a la Tracción
19.
Asian Pac J Cancer Prev ; 13(7): 3389-97, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22994766

RESUMEN

AIM: The aim of this study was to analyze studies in Turkey about self-breast examination and produce conclusive, reliable and detailed basis for future studies. METHODS: Studies performed between 2000 and 2009 (until the end of September) were retrieved from databases using breast cancer, breast examination, breast cancer screening and risk factors as key words. Fifty-nine studies were identified and 18 of them (15 journal articles and three theses) were used for the meta-analysis t. RESULTS: Married women and women with a family history of breast cancer were found to perform self-breast examination more frequently than single women and women without a family history of breast cancer, respectively (OR=1.02 %CI 0.82-1.63; OR=1.16 %CI 0.82-1.63). According to the health belief model scales, women performing self-breast examination were determined to have 1.7 times higher susceptibility (OR=1.70), 1.34 times higher seriousness perception (OR=1.34), 3.32 times higher health motivation (OR=3.32), 5.21 times more self-efficacy/confidence (OR=5.21) and 2.56 times higher self-breast examination benefit perception (OR=2.56). CONCLUSION: Nursing care models caused an increase in self-breast examination by women, and thus, it may be useful to organize and evaluate such health-related programs and consider women health perceptions.


Asunto(s)
Neoplasias de la Mama/diagnóstico , Autoexamen de Mamas , Conocimientos, Actitudes y Práctica en Salud , Adolescente , Adulto , Estudios de Casos y Controles , Detección Precoz del Cáncer/métodos , Femenino , Humanos , Tamizaje Masivo/métodos , Factores de Riesgo , Autoeficacia , Turquía
20.
Gene ; 489(2): 86-8, 2011 Dec 10.
Artículo en Inglés | MEDLINE | ID: mdl-21939743

RESUMEN

This study was conducted in Turkish patients with polycystic ovary syndrome to determine the frequency of I/D polymorphism genotypes of angiotensin converting enzyme gene, and to examine the role of this polymorphism in polycystic ovary syndrome development. Genomic DNA obtained from 200 persons (100 patients with polycystic ovary syndrome and 100 healthy controls) was used in the study. DNA was multiplied by polymerase chain reaction using I and D allele-specific primers. Polymerase chain reaction products were assessed with a charge coupled device (CCD) camera by being exposed to 2% agarose gel electrophoresis. There was statistically significant difference between the groups with respect to genotype distribution (p<0.001). The D allele frequency was indicated as 68% and I allele was as 32% in the patients, whereas it was 51.5-48.5% respectively in the control group. As a result of our study we may assert that angiotensin converting enzyme gene I/D polymorphism DD genotype should be considered as a genetic marker in polycystic ovary syndrome development in this Turkish study population.


Asunto(s)
Predisposición Genética a la Enfermedad , Peptidil-Dipeptidasa A/genética , Síndrome del Ovario Poliquístico/genética , Polimorfismo de Nucleótido Simple , Adulto , Alelos , Femenino , Frecuencia de los Genes , Marcadores Genéticos , Genotipo , Humanos , Reacción en Cadena de la Polimerasa , Turquía
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