Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies.

The most fatal malignancy of the central nervous system (CNS) is glioblastoma. Brain cancer is a 'cold' tumor because of fewer immunoregulatory cells and more immunosuppressive cells. Due to the cold nature of brain cancers, conventional treatments which are used to manage glioma patients show little effectiveness. Glioma patients even showed resistance to immune checkpoint blockade (ICB) and no significant efficacy. It has been shown that myeloid-derived suppressor cells (MDSCs) account for approximately 30-50% of the tumor mass in glioma. This study aimed to review MDSC function in brain cancer, as well as possible treatments and related challenges. In brain cancer and glioma, several differences in the context of MDSCs have been reported, including disagreements about the MDSC subtype that has the most inhibitory function in the brain, or inhibitory function of regulatory B cells (Bregs). There are also serious challenges in treating glioma patients. In addition to the cold nature of glioma, there are reports of an increase in MDSCs following conventional chemotherapy treatments. As a result, targeting MDSCs in combination with other therapies, such as ICB, is essential, and recent studies with the combination therapy approach have shown promising therapeutic effects in brain cancer.

Finite element analysis of NiTi self-expandable heart valve stent.

Transcatheter aortic valve implantation is a minimally invasive treatment for severe symptomatic aortic valve stenosis. Nitinol stents are proposed for aortic stenosis patients at high risk. In the present study, at different implantation depths in the aortic valve, the crimping and performance of Nitinol stents are investigated. To do so, a constitutive model based on Microplane theory is utilized and implemented through the finite element to express the constitutive characteristics of Nitinol. The self-expanding stent made of NiTi is designed and simulated using the finite element method. To validate the developed model, the obtained results using beam and solid finite element models are compared with those reported in the literature. Superelastic behavior as well as shape memory effect of the Nitinol stent is studied during crimping and deployment. The simulated results show that the produced radial force increases by increasing the implantation depth in a cardiac cycle.