Randomized clinical trial with fractional CO2 laser and Clobetasol in the treatment of Vulvar Lichen Sclerosus: a clinic study of feasibility.

OBJECTIVES: The main objective of the study was to describe and compare the feasibility of using fractional CO2 laser to the usual treatment with Clobetasol. Randomized clinical trials brought together 20 women from a Brazilian university hospital, 9 of them were submitted to Clobetasol treatment and 11 to laser therapy. Sociodemographic data were obtained and quality of life parameters, vulvar anatomy, self-perception and histopathological analysis of vulvar biopsies were evaluated. Evaluations were made before the beginning of the treatment, during its implementation, right after its completion (3 months), and 12 months after. The SPSS 14.0 software was used, obtaining descriptive measurements. The level of significance adopted was 5%. RESULTS: The clinical/anatomical characteristics of the vulva did not differ between the treatment groups, as much before as after its performance. There was no statistically significant difference between the treatments performed regarding the impact on the life quality of the patients. A higher satisfaction degree with the treatment was obtained with the patients in the Laser group in the third month of evaluation. Laser therapy also revealed higher occurrence of telangiectasia after treatment completion. Fractional CO2 laser has proven to be well accepted and is a promising therapeutic option. Registration number and name of trial registry The institutional review board status was approved by the Research Ethics Committee of HU/ UFJF under advisory number 2881073 and registered in the Brazilian Clinical Trials, with consent under registration RBR-4p9s5y. Access link: https://ensaiosclinicos.gov.br/rg/RBR-4p9s5y.

A utilização da progesterona natural micronizada em gestações gemelares na prevenção do trabalho de parto prematuro / Use of natural micronized progesterone in the prevention of preterm labor in twin pregnancies

Com o objetivo de determinar a eficácia da progesterona natural micronizada em gestações gemelares para a profilaxia do trabalho de parto prematuro, foi avaliada uma coorte histórica de 43 mulheres com gestações gemelares. As gestantes foram divididas em dois grupos: usuárias da progesterona (Grupo 1) e não usuárias da progesterona (Grupo 2). O medicamento foi administrado na dosagem de 200 mcg por via vaginal, a partir de 20 semanas de gestação. Das 43 gestações estudadas, 20 foram tratadas com a progesterona. Não houve associação entre uso da progesterona e época do parto, de forma que o uso da progesterona natural micronizada não impediu o parto prematuro (p = 0,87). Portanto, a progesterona natural micronizada não reduziu a frequência do trabalho de parto prematuro em gestações gemelares...

A historical cohort of 43 women with twin pregnancies were assessed to determine the effectiveness of natural micronized progesterone in twin pregnancies for the prophylaxis of preterm labor. The women were divided into two groups: progesterone users (Group 1) and non-users of progesterone (Group 2). The drug was administered at a dose of 200 mcg vaginally, from 20 weeks of gestation. Of the 43 pregnancies studied, 20 were treated with progesterone. There was no association between use of progesterone and delivery time, so that the use of natural micronized progesterone did not prevent preterm birth (p = 0.87). Therefore, natural micronized progesterone did not reduce the frequency of preterm birth in twin pregnancies...