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Bioorg Med Chem Lett
; 16(13): 3504-9, 2006 Jul 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16644217
RESUMEN
Several potent, cell permeable 4-aryl-dihydropyrimidinones have been identified as inhibitors of FATP4. Lipophilic ester substituents at the 5-position and substitution at the para-position (optimal groups being -NO(2) and CF(3)) of the 4-aryl group led to active compounds. In two cases racemates were resolved and the S enantiomers shown to have higher potencies.