Detalles de la búsqueda
1.
Translational PK/PD Modeling of Tumor Growth Inhibition and Target Inhibition to Support Dose Range Selection of the LMP7 Inhibitor M3258 in Relapsed/Refractory Multiple Myeloma.
J Pharmacol Exp Ther;
384(1): 163-172, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36273822
2.
Induced Syk deletion leads to suppressed allergic responses but has no effect on neutrophil or monocyte migration in vivo.
Eur J Immunol;
41(11): 3208-18, 2011 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-21830208
3.
Structure-Based Optimization and Discovery of M3258, a Specific Inhibitor of the Immunoproteasome Subunit LMP7 (ß5i).
J Med Chem;
64(14): 10230-10245, 2021 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34228444
4.
M3258 Is a Selective Inhibitor of the Immunoproteasome Subunit LMP7 (ß5i) Delivering Efficacy in Multiple Myeloma Models.
Mol Cancer Ther;
20(8): 1378-1387, 2021 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34045234
5.
FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response.
Eur J Cancer;
151: 136-149, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33984662
6.
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition.
Cancer Discov;
11(1): 142-157, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32816843
7.
Comparison of the anti-allergic activity of Syk inhibitors with optimized Syk siRNAs in FcepsilonRI-activated RBL-2H3 basophilic cells.
Cell Immunol;
262(1): 28-34, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20053395
8.
SHP2 Inhibition Influences Therapeutic Response to Tepotinib in Tumors with MET Alterations.
iScience;
23(12): 101832, 2020 Dec 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33305187
9.
Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance.
Mol Cancer Ther;
19(4): 1018-1030, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32024684
10.
Establishment and Analysis of a 3D Co-Culture Spheroid Model of Pancreatic Adenocarcinoma for Application in Drug Discovery.
Methods Mol Biol;
1953: 163-179, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30912022
11.
Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion.
J Cell Biochem;
103(6): 1783-97, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17910038
12.
Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage.
Cancer Res;
78(13): 3497-3509, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29735545
13.
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44.
Biochem J;
393(Pt 3): 609-18, 2006 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16229685
14.
An allometric pharmacokinetic/pharmacodynamics model for BI 893923, a novel IGF-1 receptor inhibitor.
Cancer Chemother Pharmacol;
79(3): 545-558, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28243682
15.
The IGF1R/INSR Inhibitor BI 885578 Selectively Inhibits Growth of IGF2-Overexpressing Colorectal Cancer Tumors and Potentiates the Efficacy of Anti-VEGF Therapy.
Mol Cancer Ther;
16(10): 2223-2233, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28729397
16.
Exosomes: from biogenesis and secretion to biological function.
Immunol Lett;
107(2): 102-8, 2006 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17067686
17.
A comprehensive pharmacokinetic/pharmacodynamics analysis of the novel IGF1R/INSR inhibitor BI 893923 applying in vitro, in vivo and in silico modeling techniques.
Cancer Chemother Pharmacol;
77(6): 1303-14, 2016 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-27160688
18.
BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.
Mol Cancer Ther;
14(12): 2762-72, 2015 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-26438154
19.
Syk and Lyn mediate distinct Syk phosphorylation events in FcÉRI-signal transduction: implications for regulation of IgE-mediated degranulation.
Mol Immunol;
48(1-3): 171-8, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20828828
20.
Syk: a novel target for treatment of inflammation in lung disease.
Inflamm Allergy Drug Targets;
8(2): 87-95, 2009 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-19530990