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1.
Exploration of the P1 residue in 3CL protease inhibitors leading to the discovery of a 2-tetrahydrofuran P1 replacement.
Bioorg Med Chem;
100: 117618, 2024 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-38309201
2.
Cyclic AMP-Mediated Inhibition of Cholesterol Catabolism in Mycobacterium tuberculosis by the Novel Drug Candidate GSK2556286.
Antimicrob Agents Chemother;
67(1): e0129422, 2023 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-36602336
3.
GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment.
Antimicrob Agents Chemother;
66(6): e0013222, 2022 06 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35607978
4.
1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis.
ACS Infect Dis;
8(11): 2315-2326, 2022 11 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-36325756
5.
The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation.
Cell Surf;
7: 100068, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34888432
6.
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG.
Sci Adv;
7(13)2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33762339
7.
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.
Cell Chem Biol;
27(7): 806-816.e8, 2020 07 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32359426
8.
Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.
J Med Chem;
60(24): 10118-10134, 2017 12 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-29148755
9.
Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.
ACS Infect Dis;
3(1): 18-33, 2017 01 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27704782
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