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1.

Previously unknown pathway for lipid biosynthesis discovered.

Schaffer, Jean E.

Nature; 621(7977): 47-48, 2023 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-37648821

2.

Death by lipids: The role of small nucleolar RNAs in metabolic stress.

Schaffer, Jean E.

J Biol Chem; 295(25): 8628-8635, 2020 06 19.

Artículo en Inglés | MEDLINE | ID: mdl-32393576

3.

Monitoring the itinerary of lysosomal cholesterol in Niemann-Pick Type C1-deficient cells after cyclodextrin treatment.

Feltes, McKenna; Gale, Sarah E; Moores, Samantha; Ory, Daniel S; Schaffer, Jean E.

J Lipid Res; 61(3): 403-412, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-31988149

4.

Alterations in plasma triglycerides and ceramides: links with cardiac function in humans with type 2 diabetes.

Peterson, Linda R; Jiang, Xuntian; Chen, Ling; Goldberg, Anne C; Farmer, Marsha S; Ory, Daniel S; Schaffer, Jean E.

J Lipid Res; 61(7): 1065-1074, 2020 07.

Artículo en Inglés | MEDLINE | ID: mdl-32393551

5.

Application of a glycinated bile acid biomarker for diagnosis and assessment of response to treatment in Niemann-pick disease type C1.

Sidhu, Rohini; Kell, Pamela; Dietzen, Dennis J; Farhat, Nicole Y; Do, An Ngoc Dang; Porter, Forbes D; Berry-Kravis, Elizabeth; Reunert, Janine; Marquardt, Thorsten; Giugliani, Roberto; Lourenço, Charles M; Wang, Raymond Y; Movsesyan, Nina; Plummer, Ellen; Schaffer, Jean E; Ory, Daniel S; Jiang, Xuntian.

Mol Genet Metab; 131(4): 405-417, 2020 12.

Artículo en Inglés | MEDLINE | ID: mdl-33257258

6.

Application of N-palmitoyl-O-phosphocholineserine for diagnosis and assessment of response to treatment in Niemann-Pick type C disease.

Sidhu, Rohini; Kell, Pamela; Dietzen, Dennis J; Farhat, Nicole Y; Do, An Ngoc Dang; Porter, Forbes D; Berry-Kravis, Elizabeth; Vite, Charles H; Reunert, Janine; Marquardt, Thorsten; Giugliani, Roberto; Lourenço, Charles M; Bodamer, Olaf; Wang, Raymond Y; Plummer, Ellen; Schaffer, Jean E; Ory, Daniel S; Jiang, Xuntian.

Mol Genet Metab; 129(4): 292-302, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-32033912

7.

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induce Post-Translational Modifications of AKAP121, DRP1, and OPA1 That Promote Mitochondrial Fission.

Tsushima, Kensuke; Bugger, Heiko; Wende, Adam R; Soto, Jamie; Jenson, Gregory A; Tor, Austin R; McGlauflin, Rose; Kenny, Helena C; Zhang, Yuan; Souvenir, Rhonda; Hu, Xiao X; Sloan, Crystal L; Pereira, Renata O; Lira, Vitor A; Spitzer, Kenneth W; Sharp, Terry L; Shoghi, Kooresh I; Sparagna, Genevieve C; Rog-Zielinska, Eva A; Kohl, Peter; Khalimonchuk, Oleh; Schaffer, Jean E; Abel, E Dale.

Circ Res; 122(1): 58-73, 2018 01 05.

Artículo en Inglés | MEDLINE | ID: mdl-29092894

8.

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking.

Feltes, McKenna; Moores, Samantha; Gale, Sarah E; Krishnan, Kathiresan; Mydock-McGrane, Laurel; Covey, Douglas F; Ory, Daniel S; Schaffer, Jean E.

J Lipid Res; 60(3): 707-716, 2019 03.

Artículo en Inglés | MEDLINE | ID: mdl-30617147

9.

N-acyl-O-phosphocholineserines: structures of a novel class of lipids that are biomarkers for Niemann-Pick C1 disease.

Sidhu, Rohini; Mondjinou, Yawo; Qian, Mingxing; Song, Haowei; Kumar, Arun Babu; Hong, Xinying; Hsu, Fong-Fu; Dietzen, Dennis J; Yanjanin, Nicole M; Porter, Forbes D; Berry-Kravis, Elizabeth; Vite, Charles H; Gelb, Michael H; Schaffer, Jean E; Ory, Daniel S; Jiang, Xuntian.

J Lipid Res; 60(8): 1410-1424, 2019 08.

Artículo en Inglés | MEDLINE | ID: mdl-31201291

10.

Long-range function of secreted small nucleolar RNAs that direct 2'-O-methylation.

Rimer, Jamie M; Lee, Jiyeon; Holley, Christopher L; Crowder, Robert J; Chen, Delphine L; Hanson, Phyllis I; Ory, Daniel S; Schaffer, Jean E.

J Biol Chem; 293(34): 13284-13296, 2018 08 24.

Artículo en Inglés | MEDLINE | ID: mdl-29980600

11.

Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.

Goldberg, Ira J; Reue, Karen; Abumrad, Nada A; Bickel, Perry E; Cohen, Sarah; Fisher, Edward A; Galis, Zorina S; Granneman, James G; Lewandowski, E Douglas; Murphy, Robert; Olive, Michelle; Schaffer, Jean E; Schwartz-Longacre, Lisa; Shulman, Gerald I; Walther, Tobias C; Chen, Jue.

Circulation; 138(3): 305-315, 2018 07 17.

Artículo en Inglés | MEDLINE | ID: mdl-30012703

12.

Diagnosis of niemann-pick C1 by measurement of bile acid biomarkers in archived newborn dried blood spots.

Jiang, Xuntian; Sidhu, Rohini; Orsini, Joseph J; Farhat, Nicole Y; Porter, Forbes D; Berry-Kravis, Elizabeth; Schaffer, Jean E; Ory, Daniel S.

Mol Genet Metab; 126(2): 183-187, 2019 02.

Artículo en Inglés | MEDLINE | ID: mdl-30172462

13.

Nuclear export factor 3 regulates localization of small nucleolar RNAs.

Li, Melissa W; Sletten, Arthur C; Lee, Jiyeon; Pyles, Kelly D; Matkovich, Scot J; Ory, Daniel S; Schaffer, Jean E.

J Biol Chem; 292(49): 20228-20239, 2017 12 08.

Artículo en Inglés | MEDLINE | ID: mdl-29021253

14.

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis.

McCommis, Kyle S; Hodges, Wesley T; Brunt, Elizabeth M; Nalbantoglu, Ilke; McDonald, William G; Holley, Christopher; Fujiwara, Hideji; Schaffer, Jean E; Colca, Jerry R; Finck, Brian N.

Hepatology; 65(5): 1543-1556, 2017 05.

Artículo en Inglés | MEDLINE | ID: mdl-28027586

15.

A HILIC-MS/MS method for simultaneous quantification of the lysosomal disease markers galactosylsphingosine and glucosylsphingosine in mouse serum.

Sidhu, Rohini; Mikulka, Christina R; Fujiwara, Hideji; Sands, Mark S; Schaffer, Jean E; Ory, Daniel S; Jiang, Xuntian.

Biomed Chromatogr; 32(7): e4235, 2018 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-29516569

16.

Effects of Inhibiting VPS4 Support a General Role for ESCRTs in Extracellular Vesicle Biogenesis.

Jackson, Charles E; Scruggs, Benjamin S; Schaffer, Jean E; Hanson, Phyllis I.

Biophys J; 113(6): 1342-1352, 2017 09 19.

Artículo en Inglés | MEDLINE | ID: mdl-28629620

17.

A murine Niemann-Pick C1 I1061T knock-in model recapitulates the pathological features of the most prevalent human disease allele.

Praggastis, Maria; Tortelli, Brett; Zhang, Jessie; Fujiwara, Hideji; Sidhu, Rohini; Chacko, Anita; Chen, Zhouji; Chung, Chan; Lieberman, Andrew P; Sikora, Jakub; Davidson, Cristin; Walkley, Steven U; Pipalia, Nina H; Maxfield, Frederick R; Schaffer, Jean E; Ory, Daniel S.

J Neurosci; 35(21): 8091-106, 2015 May 27.

Artículo en Inglés | MEDLINE | ID: mdl-26019327

18.

Cytosolic accumulation of small nucleolar RNAs (snoRNAs) is dynamically regulated by NADPH oxidase.

Holley, Christopher L; Li, Melissa W; Scruggs, Benjamin S; Matkovich, Scot J; Ory, Daniel S; Schaffer, Jean E.

J Biol Chem; 290(18): 11741-8, 2015 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-25792744

19.

Cholesterol homeostatic responses provide biomarkers for monitoring treatment for the neurodegenerative disease Niemann-Pick C1 (NPC1).

Tortelli, Brett; Fujiwara, Hideji; Bagel, Jessica H; Zhang, Jessie; Sidhu, Rohini; Jiang, Xuntian; Yanjanin, Nicole M; Shankar, Roopa Kanakatti; Carillo-Carasco, Nuria; Heiss, John; Ottinger, Elizabeth; Porter, Forbes D; Schaffer, Jean E; Vite, Charles H; Ory, Daniel S.

Hum Mol Genet; 23(22): 6022-33, 2014 Nov 15.

Artículo en Inglés | MEDLINE | ID: mdl-24964810

20.

Plasma sphingolipids associated with chronic obstructive pulmonary disease phenotypes.

Bowler, Russell P; Jacobson, Sean; Cruickshank, Charmion; Hughes, Grant J; Siska, Charlotte; Ory, Daniel S; Petrache, Irina; Schaffer, Jean E; Reisdorph, Nichole; Kechris, Katerina.

Am J Respir Crit Care Med; 191(3): 275-84, 2015 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-25494452

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