Detalles de la búsqueda
1.
Species-dependent hepatic and intestinal metabolism of selective oestrogen receptor degrader LSZ102 by sulphation and glucuronidation.
Xenobiotica;
52(1): 26-37, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-35098863
2.
Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes.
Pulm Pharmacol Ther;
57: 101809, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31195091
3.
Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
Xenobiotica;
48(8): 793-803, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-28879796
4.
Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors.
Xenobiotica;
46(10): 862-7, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-26887925
5.
Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.
Drug Metab Dispos;
43(1): 126-39, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25339109
6.
Aldehyde oxidase activity in fresh human skin.
Drug Metab Dispos;
42(12): 2049-57, 2014 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-25249692
7.
Use of Pharmacokinetic and Pharmacodynamic Data to Develop the CDK4/6 Inhibitor Ribociclib for Patients with Advanced Breast Cancer.
Clin Pharmacokinet;
63(2): 155-170, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38244190
8.
The potential of Sutherlandia frutescens for herb-drug interaction.
Drug Metab Dispos;
41(2): 488-97, 2013 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-23209194
9.
The potential of Hypoxis hemerocallidea for herb-drug interaction.
Pharm Biol;
51(12): 1499-507, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-23844611
10.
Industry Perspective on Therapeutic Peptide Drug-Drug Interaction Assessments During Drug Development: A European Federation of Pharmaceutical Industries and Associations White Paper.
Clin Pharmacol Ther;
113(6): 1199-1216, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36633114
11.
Therapeutic Protein Drug Interactions: A White Paper From the International Consortium for Innovation and Quality in Pharmaceutical Development.
Clin Pharmacol Ther;
113(6): 1185-1198, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-36477720
12.
Novel Bruton's tyrosine kinase inhibitor remibrutinib: Assessment of drug-drug interaction potential as a perpetrator of cytochrome P450 enzymes and drug transporters and the impact of covalent binding on possible drug interactions.
Eur J Pharm Sci;
172: 106155, 2022 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35247543
13.
Novel Bruton's Tyrosine Kinase inhibitor remibrutinib: Drug-drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling.
Clin Transl Sci;
15(1): 118-129, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34432364
14.
An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data.
Pharmacol Res Perspect;
8(3): e00599, 2020 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-32524755
15.
Ribociclib Drug-Drug Interactions: Clinical Evaluations and Physiologically-Based Pharmacokinetic Modeling to Guide Drug Labeling.
Clin Pharmacol Ther;
108(3): 575-585, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32557601
16.
Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions.
Drug Metab Pers Ther;
34(2)2019 05 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-31145690
17.
Examining P-gp efflux kinetics guided by the BDDCS - Rational selection of in vitro assay designs and mathematical models.
Eur J Pharm Sci;
132: 132-141, 2019 Apr 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-30857914
18.
The BACE-1 inhibitor CNP520 for prevention trials in Alzheimer's disease.
EMBO Mol Med;
10(11)2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30224383
19.
Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.
Drug Metab Pers Ther;
32(4): 191-200, 2017 Dec 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-29176011
20.
Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.
Drug Metab Pers Ther;
31(4): 221-228, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27718490