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1.

EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart.

Hambarde, Shashank; Tsai, Chi-Lin; Pandita, Raj K; Bacolla, Albino; Maitra, Anirban; Charaka, Vijay; Hunt, Clayton R; Kumar, Rakesh; Limbo, Oliver; Le Meur, Remy; Chazin, Walter J; Tsutakawa, Susan E; Russell, Paul; Schlacher, Katharina; Pandita, Tej K; Tainer, John A.

Mol Cell; 81(14): 2989-3006.e9, 2021 07 15.

Artículo en Inglés | MEDLINE | ID: mdl-34197737

2.

Double-strand break repair-independent role for BRCA2 in blocking stalled replication fork degradation by MRE11.

Schlacher, Katharina; Christ, Nicole; Siaud, Nicolas; Egashira, Akinori; Wu, Hong; Jasin, Maria.

Cell; 145(4): 529-42, 2011 May 13.

Artículo en Inglés | MEDLINE | ID: mdl-21565612

3.

Abro1 maintains genome stability and limits replication stress by protecting replication fork stability.

Xu, Shengfeng; Wu, Xiao; Wu, Ling; Castillo, Andy; Liu, Jianxin; Atkinson, Erin; Paul, Atanu; Su, Dan; Schlacher, Katharina; Komatsu, Yoshihiro; You, M James; Wang, Bin.

Genes Dev; 31(14): 1469-1482, 2017 07 15.

Artículo en Inglés | MEDLINE | ID: mdl-28860160

4.

Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication.

Guo, Cai; Kumagai, Akiko; Schlacher, Katharina; Shevchenko, Anna; Shevchenko, Andrej; Dunphy, William G.

Mol Cell; 57(3): 492-505, 2015 Feb 05.

Artículo en Inglés | MEDLINE | ID: mdl-25557548

5.

A new road to cancer-drug resistance.

Schlacher, Katharina.

Nature; 563(7732): 478-480, 2018 11.

Artículo en Inglés | MEDLINE | ID: mdl-30459368

6.

Constitutive role of the Fanconi anemia D2 gene in the replication stress response.

Tian, Yanyan; Shen, Xi; Wang, Rui; Klages-Mundt, Naeh L; Lynn, Erica J; Martin, Sara K; Ye, Yin; Gao, Min; Chen, Junjie; Schlacher, Katharina; Li, Lei.

J Biol Chem; 292(49): 20184-20195, 2017 12 08.

Artículo en Inglés | MEDLINE | ID: mdl-29021208

7.

Plasticity of BRCA2 function in homologous recombination: genetic interactions of the PALB2 and DNA binding domains.

Siaud, Nicolas; Barbera, Maria A; Egashira, Akinori; Lam, Isabel; Christ, Nicole; Schlacher, Katharina; Xia, Bing; Jasin, Maria.

PLoS Genet; 7(12): e1002409, 2011 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-22194698

8.

Targeting ATR in patients with cancer.

Ngoi, Natalie Y L; Pilié, Patrick G; McGrail, Daniel J; Zimmermann, Michal; Schlacher, Katharina; Yap, Timothy A.

Nat Rev Clin Oncol; 21(4): 278-293, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38378898

9.

GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer.

Ye, Zu; Xu, Shengfeng; Shi, Yin; Cheng, Xueqian; Zhang, Yuan; Roy, Sunetra; Namjoshi, Sarita; Longo, Michael A; Link, Todd M; Schlacher, Katharina; Peng, Guang; Yu, Dihua; Wang, Bin; Tainer, John A; Ahmed, Zamal.

Nat Commun; 15(1): 2132, 2024 Mar 08.

Artículo en Inglés | MEDLINE | ID: mdl-38459011

10.

Mitochondrial Replication Assay (MIRA) for Efficient in situ Quantification of Nascent mtDNA and Protein Interactions with Nascent mtDNA (mitoSIRF).

Lozen, Macy; Chen, Yue; Boisvert, Rebecca A; Schlacher, Katharina.

Bio Protoc; 13(10): e4680, 2023 May 20.

Artículo en Inglés | MEDLINE | ID: mdl-37251092

11.

Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress.

Tomaszowski, Karl-Heinz; Roy, Sunetra; Guerrero, Carolina; Shukla, Poojan; Keshvani, Caezaan; Chen, Yue; Ott, Martina; Wu, Xiaogang; Zhang, Jianhua; DiNardo, Courtney D; Schindler, Detlev; Schlacher, Katharina.

Nat Commun; 14(1): 1333, 2023 03 11.

Artículo en Inglés | MEDLINE | ID: mdl-36906610

12.

RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles.

Longo, Michael A; Roy, Sunetra; Chen, Yue; Tomaszowski, Karl-Heinz; Arvai, Andrew S; Pepper, Jordan T; Boisvert, Rebecca A; Kunnimalaiyaan, Selvi; Keshvani, Caezanne; Schild, David; Bacolla, Albino; Williams, Gareth J; Tainer, John A; Schlacher, Katharina.

Nat Commun; 14(1): 4445, 2023 07 24.

Artículo en Inglés | MEDLINE | ID: mdl-37488098

13.

RecA acts in trans to allow replication of damaged DNA by DNA polymerase V.

Schlacher, Katharina; Cox, Michael M; Woodgate, Roger; Goodman, Myron F.

Nature; 442(7105): 883-7, 2006 Aug 24.

Artículo en Inglés | MEDLINE | ID: mdl-16929290

14.

MRE11-dependent instability in mitochondrial DNA fork protection activates a cGAS immune signaling pathway.

Luzwick, Jessica W; Dombi, Eszter; Boisvert, Rebecca A; Roy, Sunetra; Park, Soyoung; Kunnimalaiyaan, Selvi; Goffart, Steffi; Schindler, Detlev; Schlacher, Katharina.

Sci Adv; 7(51): eabf9441, 2021 Dec 17.

Artículo en Inglés | MEDLINE | ID: mdl-34910513

15.

APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis.

Wörmann, Sonja M; Zhang, Amy; Thege, Fredrik I; Cowan, Robert W; Rupani, Dhwani N; Wang, Runsheng; Manning, Sara L; Gates, Chris; Wu, Weisheng; Levin-Klein, Rena; Rajapakshe, Kimal I; Yu, Meifang; Multani, Asha S; Kang, Ya'an; Taniguchi, Cullen M; Schlacher, Katharina; Bellin, Melena D; Katz, Matthew H G; Kim, Michael P; Fleming, Jason B; Gallinger, Steven; Maddipati, Ravikanth; Harris, Reuben S; Notta, Faiyaz; Ross, Susan R; Maitra, Anirban; Rhim, Andrew D.

Nat Cancer; 2(12): 1338-1356, 2021 12.

Artículo en Inglés | MEDLINE | ID: mdl-35121902

16.

Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma.

Msaouel, Pavlos; Malouf, Gabriel G; Su, Xiaoping; Yao, Hui; Tripathi, Durga N; Soeung, Melinda; Gao, Jianjun; Rao, Priya; Coarfa, Cristian; Creighton, Chad J; Bertocchio, Jean-Philippe; Kunnimalaiyaan, Selvi; Multani, Asha S; Blando, Jorge; He, Rong; Shapiro, Daniel D; Perelli, Luigi; Srinivasan, Sanjana; Carbone, Federica; Pilié, Patrick G; Karki, Menuka; Seervai, Riyad N H; Vokshi, Bujamin H; Lopez-Terrada, Dolores; Cheng, Emily H; Tang, Ximing; Lu, Wei; Wistuba, Ignacio I; Thompson, Timothy C; Davidson, Irwin; Giuliani, Virginia; Schlacher, Katharina; Carugo, Alessandro; Heffernan, Timothy P; Sharma, Padmanee; Karam, Jose A; Wood, Christopher G; Walker, Cheryl L; Genovese, Giannicola; Tannir, Nizar M.

Cancer Cell; 37(5): 720-734.e13, 2020 05 11.

Artículo en Inglés | MEDLINE | ID: mdl-32359397

17.

Sense and sensibility: ATM oxygen stress signaling manages brain cell energetics.

Schlacher, Katharina.

J Cell Biol; 218(3): 732-734, 2019 03 04.

Artículo en Inglés | MEDLINE | ID: mdl-30782782

18.

SIRF: A Single-cell Assay for in situ Protein Interaction with Nascent DNA Replication Forks.

Roy, Sunetra; Schlacher, Katharina.

Bio Protoc; 9(18): e3377, 2019 Sep 20.

Artículo en Inglés | MEDLINE | ID: mdl-33654873

19.

Detection and Quantitation of Acetylated Histones on Replicating DNA Using In Situ Proximity Ligation Assay and Click-It Chemistry.

Lazarchuk, Pavlo; Roy, Sunetra; Schlacher, Katharina; Sidorova, Julia.

Methods Mol Biol; 1983: 29-45, 2019.

Artículo en Inglés | MEDLINE | ID: mdl-31087291

20.

Author Correction: Hypomorphic Brca2 and Rad51c double mutant mice display Fanconi anemia, cancer and polygenic replication stress.