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1.

One Step at a Time - Clinical Evidence That KRAS Is Indeed Druggable.

LoRusso, Patricia M; Sebolt-Leopold, Judith S.

N Engl J Med; 383(13): 1277-1278, 2020 09 24.

Artículo en Inglés | MEDLINE | ID: mdl-32955175

2.

Development of Preclinical Models to Understand and Treat Colorectal Cancer.

Sebolt-Leopold, Judith S.

Clin Colon Rectal Surg; 31(3): 199-204, 2018 May.

Artículo en Inglés | MEDLINE | ID: mdl-29720906

3.

MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice.

Collins, Meredith A; Yan, Wei; Sebolt-Leopold, Judith S; Pasca di Magliano, Marina.

Gastroenterology; 146(3): 822-834.e7, 2014 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-24315826

4.

Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.

Van Dort, Marcian E; Galbán, Stefanie; Wang, Hanxiao; Sebolt-Leopold, Judith; Whitehead, Christopher; Hong, Hao; Rehemtulla, Alnawaz; Ross, Brian D.

Bioorg Med Chem; 23(7): 1386-94, 2015 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-25766633

5.

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.

Lauchle, Jennifer O; Kim, Doris; Le, Doan T; Akagi, Keiko; Crone, Michael; Krisman, Kimberly; Warner, Kegan; Bonifas, Jeannette M; Li, Qing; Coakley, Kristen M; Diaz-Flores, Ernesto; Gorman, Matthew; Przybranowski, Sally; Tran, Mary; Kogan, Scott C; Roose, Jeroen P; Copeland, Neal G; Jenkins, Nancy A; Parada, Luis; Wolff, Linda; Sebolt-Leopold, Judith; Shannon, Kevin.

Nature; 461(7262): 411-4, 2009 Sep 17.

Artículo en Inglés | MEDLINE | ID: mdl-19727076

6.

ERK activation is required for CCK-mediated pancreatic adaptive growth in mice.

Holtz, Bryan J; Lodewyk, Kevin B; Sebolt-Leopold, Judith S; Ernst, Stephen A; Williams, John A.

Am J Physiol Gastrointest Liver Physiol; 307(7): G700-10, 2014 Oct 01.

Artículo en Inglés | MEDLINE | ID: mdl-25104499

7.

Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence.

Sharma, Monika; Barravecchia, Ivana; Teis, Robert; Cruz, Jeanette; Mumby, Rachel; Ziemke, Elizabeth K; Espinoza, Carlos E; Krishnamoorthy, Varunkumar; Magnuson, Brian; Ljungman, Mats; Koschmann, Carl; Chandra, Joya; Whitehead, Christopher E; Sebolt-Leopold, Judith S; Galban, Stefanie.

Mol Cancer Ther; 23(1): 24-34, 2024 Jan 03.

Artículo en Inglés | MEDLINE | ID: mdl-37723046

8.

Targeting the mitogen-activated protein kinase cascade to treat cancer.

Sebolt-Leopold, Judith S; Herrera, Roman.

Nat Rev Cancer; 4(12): 937-47, 2004 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-15573115

9.

Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition.

Abecunas, Cara; Whitehead, Christopher E; Ziemke, Elizabeth K; Baumann, Douglas G; Frankowski-McGregor, Christy L; Sebolt-Leopold, Judith S; Fallahi-Sichani, Mohammad.

Cancer Res; 83(2): 316-331, 2023 01 18.

Artículo en Inglés | MEDLINE | ID: mdl-36409827

10.

Mechanisms of drug inhibition of signalling molecules.

Sebolt-Leopold, Judith S; English, Jessie M.

Nature; 441(7092): 457-62, 2006 May 25.

Artículo en Inglés | MEDLINE | ID: mdl-16724058

11.

BRAF mutation predicts sensitivity to MEK inhibition.

Solit, David B; Garraway, Levi A; Pratilas, Christine A; Sawai, Ayana; Getz, Gad; Basso, Andrea; Ye, Qing; Lobo, Jose M; She, Yuhong; Osman, Iman; Golub, Todd R; Sebolt-Leopold, Judith; Sellers, William R; Rosen, Neal.

Nature; 439(7074): 358-62, 2006 Jan 19.

Artículo en Inglés | MEDLINE | ID: mdl-16273091

12.

Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies.

Rauen, Katherine A; Banerjee, Anuradha; Bishop, W Robert; Lauchle, Jennifer O; McCormick, Frank; McMahon, Martin; Melese, Teri; Munster, Pamela N; Nadaf, Sorena; Packer, Roger J; Sebolt-Leopold, Judith; Viskochil, David H.

Am J Med Genet C Semin Med Genet; 157C(2): 136-46, 2011 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-21495172

13.

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.

Rauen, Katherine A; Schoyer, Lisa; McCormick, Frank; Lin, Angela E; Allanson, Judith E; Stevenson, David A; Gripp, Karen W; Neri, Giovanni; Carey, John C; Legius, Eric; Tartaglia, Marco; Schubbert, Suzanne; Roberts, Amy E; Gelb, Bruce D; Shannon, Kevin; Gutmann, David H; McMahon, Martin; Guerra, Carmen; Fagin, James A; Yu, Benjamin; Aoki, Yoko; Neel, Benjamin G; Balmain, Allan; Drake, Richard R; Nolan, Garry P; Zenker, Martin; Bollag, Gideon; Sebolt-Leopold, Judith; Gibbs, Jackson B; Silva, Alcino J; Patton, E Elizabeth; Viskochil, David H; Kieran, Mark W; Korf, Bruce R; Hagerman, Randi J; Packer, Roger J; Melese, Teri.

Am J Med Genet A; 152A(1): 4-24, 2010 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-20014119

14.

Deciphering the Complexity of MEK Mutations in the Clinic.

Whitehead, Christopher E; Sebolt-Leopold, Judith S.

Cancer Res; 80(19): 4042-4043, 2020 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-33008803

15.

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.

Ohren, Jeffrey F; Chen, Huifen; Pavlovsky, Alexander; Whitehead, Christopher; Zhang, Erli; Kuffa, Peter; Yan, Chunhong; McConnell, Patrick; Spessard, Cindy; Banotai, Craig; Mueller, W Thomas; Delaney, Amy; Omer, Charles; Sebolt-Leopold, Judith; Dudley, David T; Leung, Iris K; Flamme, Cathlin; Warmus, Joseph; Kaufman, Michael; Barrett, Stephen; Tecle, Haile; Hasemann, Charles A.

Nat Struct Mol Biol; 11(12): 1192-7, 2004 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-15543157

16.

Advances in the development of cancer therapeutics directed against the RAS-mitogen-activated protein kinase pathway.

Sebolt-Leopold, Judith S.

Clin Cancer Res; 14(12): 3651-6, 2008 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-18559577

17.

Pancreatic cancer cell genetics and signaling response to treatment correlate with efficacy of gemcitabine-based molecular targeting strategies.

Holcomb, Bryan; Yip-Schneider, Michele T; Matos, Jesus M; Dixon, Jennifer; Kennard, Jason; Mahomed, Julie; Shanmugam, Rajasubramaniam; Sebolt-Leopold, Judith; Schmidt, C Max.

J Gastrointest Surg; 12(2): 288-96, 2008 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-18049840

18.

Targeting MEK is effective chemoprevention of hepatocellular carcinoma in TGF-alpha-transgenic mice.

Wentz, Sabrina C; Wu, Huangbing; Yip-Schneider, Michele T; Hennig, Matthew; Klein, Patrick J; Sebolt-Leopold, Judith; Schmidt, C Max.

J Gastrointest Surg; 12(1): 30-7, 2008 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-17987349

19.

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901.

Barrett, Stephen D; Bridges, Alexander J; Dudley, David T; Saltiel, Alan R; Fergus, James H; Flamme, Cathlin M; Delaney, Amy M; Kaufman, Michael; LePage, Sophie; Leopold, Wilbur R; Przybranowski, Sally A; Sebolt-Leopold, Judith; Van Becelaere, Keri; Doherty, Annette M; Kennedy, Robert M; Marston, Dan; Howard, W Allen; Smith, Yvonne; Warmus, Joseph S; Tecle, Haile.

Bioorg Med Chem Lett; 18(24): 6501-4, 2008 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-18952427

20.

Oncogenic Mutants of MEK1: A Trilogy Unfolds.

Maust, Joel D; Whitehead, Christopher E; Sebolt-Leopold, Judith S.

Cancer Discov; 8(5): 534-536, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29716939

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