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1.
Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration.
Hum Mol Genet;
32(2): 204-217, 2023 01 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35943778
2.
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc Natl Acad Sci U S A;
116(16): 7926-7931, 2019 04 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30926668
3.
Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
Bioorg Med Chem Lett;
28(5): 906-909, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29433930
4.
trans-(3S,4S)-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part I: prime site exploration using an amino linker.
Bioorg Med Chem Lett;
25(8): 1782-1786, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25782742
5.
trans-3,4-Disubstituted pyrrolidines as inhibitors of the human aspartyl protease renin. Part II: prime site exploration using an oxygen linker.
Bioorg Med Chem Lett;
25(8): 1787-1791, 2015 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25754490
6.
Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.
Nat Cancer;
2024 Apr 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38565920
7.
Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.
ChemMedChem;
18(11): e202300051, 2023 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36988034
8.
The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition.
ChemMedChem;
17(19): e202200303, 2022 10 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35950546
9.
Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer.
Cancer Immunol Res;
9(7): 790-810, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33990375
10.
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J Med Chem;
63(11): 5697-5722, 2020 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32073845
11.
Dendritically Cross-Linking Chiral Ligands: High Stability of a Polystyrene-Bound Ti-TADDOLate Catalyst with Diffusion Control.
Angew Chem Int Ed Engl;
38(13-14): 1918-1920, 1999 Jul 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34182684
12.
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.
J Med Chem;
56(6): 2207-17, 2013 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23425156
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